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B1L4L3 (B1L4L3_KORCO) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase HAMAP MF_00435
Gene names
Name:ilvC HAMAP MF_00435
Ordered Locus Names:Kcr_0639
OrganismKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifier374847 [NCBI]
Taxonomic lineageArchaea › Korarchaeota › Candidatus Korarchaeum

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1061 By similarity HAMAP MF_00435

Sequences

Sequence LengthMass (Da)Tools
B1L4L3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 5B994122E089318E

FASTA32536,247
        10         20         30         40         50         60 
MAKIYTDNEV SLDPLKGKRI AVVGYGIQGR AQALNLRDSG LDVIVGARKG SSYDLAKREG 

        70         80         90        100        110        120 
FDVFPIGEAV SRADVILYLL PDMVQPEVWG EVERNLRDGS TLDFAHGFTI HYGLIRPKET 

       130        140        150        160        170        180 
VDIVMVAPKA PGAAVREEFL RGRGVPALVA VHRDATGEAK ARALALAKGI GATRAGVIET 

       190        200        210        220        230        240 
TFKEETETDL IGEQLVLVGG LMELITKGWE TLVEMGYQPE VAYFEALNEA KLIMDLIWRY 

       250        260        270        280        290        300 
GMKGMLERVS VTARYGGLTV GNKVIDEEVK RKMRTYAERV VSGEFTKEWL KFYKEGNIEE 

       310        320 
LMKRIGEHKI EETGRKIREI IFREP

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References

[1]"A korarchaeal genome reveals new insights into the evolution of the Archaea."
Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O.
Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed: 18535141] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OPF8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000968 Genomic DNA. Translation: ACB07392.1.
RefSeqYP_001737075.1. NC_010482.1.

3D structure databases

ProteinModelPortalB1L4L3.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1L4L3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6093923.
GenomeReviewsGene locus Kcr_0639 in contig CP000968_GR.
KEGGkcr:Kcr_0639.

Phylogenomic databases

HOGENOMHBG286525.
OMAMAYAKGI.
PhylomeDBB1L4L3.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB1L4L3_KORCO
AccessionPrimary (citable) accession number: B1L4L3
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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