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B1L3V2

- DNLI2_KORCO

UniProt

B1L3V2 - DNLI2_KORCO

Protein

DNA ligase 2

Gene

lig2

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei250 – 2501ATPUniRule annotation
    Active sitei252 – 2521N6-AMP-lysine intermediateUniRule annotation
    Binding sitei257 – 2571ATPUniRule annotation
    Binding sitei273 – 2731ATPUniRule annotation
    Binding sitei303 – 3031ATPUniRule annotation
    Binding sitei343 – 3431ATPUniRule annotation
    Binding sitei419 – 4191ATPUniRule annotation
    Binding sitei425 – 4251ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciKCRY374847:GH12-378-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
    Gene namesi
    Name:lig2UniRule annotation
    Ordered Locus Names:Kcr_0375
    OrganismiKorarchaeum cryptofilum (strain OPF8)
    Taxonomic identifieri374847 [NCBI]
    Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
    ProteomesiUP000001686: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594DNA ligase 2PRO_0000365250Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi374847.Kcr_0375.

    Structurei

    3D structure databases

    ProteinModelPortaliB1L3V2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    HOGENOMiHOG000036008.
    KOiK10747.
    OMAiLDPSGYN.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1L3V2-1 [UniParc]FASTAAdd to Basket

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    MNFIDVAKIY EKIEATTGRL EMIDYLKNLF LSTPPEILDK IVYLTLGNIA    50
    ASFEGIELGV GEKLFLRALS LATGIPQERL EEEYPKLGDI GKLAEWAVSK 100
    KAAQSFFTED LTVERVFDTL SKVARATGEG AQDLKVRLIA GILSDAKPLE 150
    ARYIARIVTE KLRLGVRDMT VLDALSEAFL KGRAYRDKLE RKYNIYPDIG 200
    KIAKVVAEKG IKGLDEITIT LGIPVRPMLA QRLRSAEEIM EKIGPRIFAE 250
    FKYDGERMQI HVWKDGKVKI FSRRLEDITE PYPDVREYVS KAVEGHEVVL 300
    DCETVAINPD TGEILPFQEL MHRRRKYGVE EAMKTYPTVT YAFDLLYLDG 350
    RELLDEQLDD RRKILKEILK ENEKARLVQY EEIDGNVEEL ERFFEHAVEM 400
    GTEGLVVKDP KSIYQAGVRG WSWIKLKRSY ISKMIEPVDL VVVGAFWGKG 450
    KRAGTYGALL MAAYSPEEDV FKTVCKMGSG FTDEELARMP KLLEDYKIDH 500
    KHPSVISNIE ADVYFVPVKV AQVLGDEITL SPTHTCGWNK VRKNAGLAIR 550
    FPRFMGWRDD KGPQDATTEE EIIEMYKEQL KVVEVEETKS EEEA 594
    Length:594
    Mass (Da):67,657
    Last modified:April 29, 2008 - v1
    Checksum:i662A34BCFC2A573E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB07131.1.
    RefSeqiYP_001736814.1. NC_010482.1.

    Genome annotation databases

    EnsemblBacteriaiACB07131; ACB07131; Kcr_0375.
    GeneIDi6093662.
    KEGGikcr:Kcr_0375.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000968 Genomic DNA. Translation: ACB07131.1 .
    RefSeqi YP_001736814.1. NC_010482.1.

    3D structure databases

    ProteinModelPortali B1L3V2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 374847.Kcr_0375.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACB07131 ; ACB07131 ; Kcr_0375 .
    GeneIDi 6093662.
    KEGGi kcr:Kcr_0375.

    Phylogenomic databases

    eggNOGi COG1793.
    HOGENOMi HOG000036008.
    KOi K10747.
    OMAi LDPSGYN.

    Enzyme and pathway databases

    BioCyci KCRY374847:GH12-378-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: OPF8.

    Entry informationi

    Entry nameiDNLI2_KORCO
    AccessioniPrimary (citable) accession number: B1L3V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3