Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B1L3V2 (DNLI2_KORCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA ligase 2

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene names
Name:lig2
Ordered Locus Names:Kcr_0375
OrganismKorarchaeum cryptofilum (strain OPF8) [Reference proteome] [HAMAP]
Taxonomic identifier374847 [NCBI]
Taxonomic lineageArchaeaKorarchaeotaCandidatus Korarchaeum

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594DNA ligase 2 HAMAP-Rule MF_00407
PRO_0000365250

Sites

Active site2521N6-AMP-lysine intermediate By similarity
Binding site2501ATP By similarity
Binding site2571ATP By similarity
Binding site2731ATP By similarity
Binding site3031ATP By similarity
Binding site3431ATP By similarity
Binding site4191ATP By similarity
Binding site4251ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1L3V2 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 662A34BCFC2A573E

FASTA59467,657
        10         20         30         40         50         60 
MNFIDVAKIY EKIEATTGRL EMIDYLKNLF LSTPPEILDK IVYLTLGNIA ASFEGIELGV 

        70         80         90        100        110        120 
GEKLFLRALS LATGIPQERL EEEYPKLGDI GKLAEWAVSK KAAQSFFTED LTVERVFDTL 

       130        140        150        160        170        180 
SKVARATGEG AQDLKVRLIA GILSDAKPLE ARYIARIVTE KLRLGVRDMT VLDALSEAFL 

       190        200        210        220        230        240 
KGRAYRDKLE RKYNIYPDIG KIAKVVAEKG IKGLDEITIT LGIPVRPMLA QRLRSAEEIM 

       250        260        270        280        290        300 
EKIGPRIFAE FKYDGERMQI HVWKDGKVKI FSRRLEDITE PYPDVREYVS KAVEGHEVVL 

       310        320        330        340        350        360 
DCETVAINPD TGEILPFQEL MHRRRKYGVE EAMKTYPTVT YAFDLLYLDG RELLDEQLDD 

       370        380        390        400        410        420 
RRKILKEILK ENEKARLVQY EEIDGNVEEL ERFFEHAVEM GTEGLVVKDP KSIYQAGVRG 

       430        440        450        460        470        480 
WSWIKLKRSY ISKMIEPVDL VVVGAFWGKG KRAGTYGALL MAAYSPEEDV FKTVCKMGSG 

       490        500        510        520        530        540 
FTDEELARMP KLLEDYKIDH KHPSVISNIE ADVYFVPVKV AQVLGDEITL SPTHTCGWNK 

       550        560        570        580        590 
VRKNAGLAIR FPRFMGWRDD KGPQDATTEE EIIEMYKEQL KVVEVEETKS EEEA 

« Hide

References

[1]"A korarchaeal genome reveals new insights into the evolution of the Archaea."
Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O.
Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OPF8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000968 Genomic DNA. Translation: ACB07131.1.
RefSeqYP_001736814.1. NC_010482.1.

3D structure databases

ProteinModelPortalB1L3V2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING374847.Kcr_0375.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB07131; ACB07131; Kcr_0375.
GeneID6093662.
KEGGkcr:Kcr_0375.

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK10747.
OMALDPSGYN.

Enzyme and pathway databases

BioCycKCRY374847:GH12-378-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI2_KORCO
AccessionPrimary (citable) accession number: B1L3V2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families