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Protein

DNA ligase 2

Gene

lig2

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1
Active sitei252N6-AMP-lysine intermediateUniRule annotation1
Binding sitei257ATPUniRule annotation1
Binding sitei273ATPUniRule annotation1
Binding sitei303ATPUniRule annotation1
Binding sitei343ATPUniRule annotation1
Binding sitei419ATPUniRule annotation1
Binding sitei425ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
Gene namesi
Name:lig2UniRule annotation
Ordered Locus Names:Kcr_0375
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaCandidatus KorarchaeotaCandidatus Korarchaeum
Proteomesi
  • UP000001686 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652501 – 594DNA ligase 2Add BLAST594

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_0375.

Structurei

3D structure databases

ProteinModelPortaliB1L3V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
InParanoidiB1L3V2.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1L3V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFIDVAKIY EKIEATTGRL EMIDYLKNLF LSTPPEILDK IVYLTLGNIA
60 70 80 90 100
ASFEGIELGV GEKLFLRALS LATGIPQERL EEEYPKLGDI GKLAEWAVSK
110 120 130 140 150
KAAQSFFTED LTVERVFDTL SKVARATGEG AQDLKVRLIA GILSDAKPLE
160 170 180 190 200
ARYIARIVTE KLRLGVRDMT VLDALSEAFL KGRAYRDKLE RKYNIYPDIG
210 220 230 240 250
KIAKVVAEKG IKGLDEITIT LGIPVRPMLA QRLRSAEEIM EKIGPRIFAE
260 270 280 290 300
FKYDGERMQI HVWKDGKVKI FSRRLEDITE PYPDVREYVS KAVEGHEVVL
310 320 330 340 350
DCETVAINPD TGEILPFQEL MHRRRKYGVE EAMKTYPTVT YAFDLLYLDG
360 370 380 390 400
RELLDEQLDD RRKILKEILK ENEKARLVQY EEIDGNVEEL ERFFEHAVEM
410 420 430 440 450
GTEGLVVKDP KSIYQAGVRG WSWIKLKRSY ISKMIEPVDL VVVGAFWGKG
460 470 480 490 500
KRAGTYGALL MAAYSPEEDV FKTVCKMGSG FTDEELARMP KLLEDYKIDH
510 520 530 540 550
KHPSVISNIE ADVYFVPVKV AQVLGDEITL SPTHTCGWNK VRKNAGLAIR
560 570 580 590
FPRFMGWRDD KGPQDATTEE EIIEMYKEQL KVVEVEETKS EEEA
Length:594
Mass (Da):67,657
Last modified:April 29, 2008 - v1
Checksum:i662A34BCFC2A573E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB07131.1.
RefSeqiWP_012309028.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB07131; ACB07131; Kcr_0375.
GeneIDi6093662.
KEGGikcr:Kcr_0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA. Translation: ACB07131.1.
RefSeqiWP_012309028.1. NC_010482.1.

3D structure databases

ProteinModelPortaliB1L3V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi374847.Kcr_0375.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACB07131; ACB07131; Kcr_0375.
GeneIDi6093662.
KEGGikcr:Kcr_0375.

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
InParanoidiB1L3V2.
KOiK10747.
OMAiPQVVIEV.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNLI2_KORCO
AccessioniPrimary (citable) accession number: B1L3V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.