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Protein

DNA ligase 2

Gene

lig2

Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei250ATPUniRule annotation1
Active sitei252N6-AMP-lysine intermediateUniRule annotation1
Binding sitei257ATPUniRule annotation1
Binding sitei273ATPUniRule annotation1
Binding sitei303ATPUniRule annotation1
Binding sitei343ATPUniRule annotation1
Binding sitei419ATPUniRule annotation1
Binding sitei425ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKOR374847:G1GBF-387-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
Gene namesi
Name:lig2UniRule annotation
Ordered Locus Names:Kcr_0375
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaCandidatus KorarchaeotaCandidatus Korarchaeum
Proteomesi
  • UP000001686 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003652501 – 594DNA ligase 2Add BLAST594

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_0375

Structurei

3D structure databases

ProteinModelPortaliB1L3V2
SMRiB1L3V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
InParanoidiB1L3V2
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

B1L3V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFIDVAKIY EKIEATTGRL EMIDYLKNLF LSTPPEILDK IVYLTLGNIA
60 70 80 90 100
ASFEGIELGV GEKLFLRALS LATGIPQERL EEEYPKLGDI GKLAEWAVSK
110 120 130 140 150
KAAQSFFTED LTVERVFDTL SKVARATGEG AQDLKVRLIA GILSDAKPLE
160 170 180 190 200
ARYIARIVTE KLRLGVRDMT VLDALSEAFL KGRAYRDKLE RKYNIYPDIG
210 220 230 240 250
KIAKVVAEKG IKGLDEITIT LGIPVRPMLA QRLRSAEEIM EKIGPRIFAE
260 270 280 290 300
FKYDGERMQI HVWKDGKVKI FSRRLEDITE PYPDVREYVS KAVEGHEVVL
310 320 330 340 350
DCETVAINPD TGEILPFQEL MHRRRKYGVE EAMKTYPTVT YAFDLLYLDG
360 370 380 390 400
RELLDEQLDD RRKILKEILK ENEKARLVQY EEIDGNVEEL ERFFEHAVEM
410 420 430 440 450
GTEGLVVKDP KSIYQAGVRG WSWIKLKRSY ISKMIEPVDL VVVGAFWGKG
460 470 480 490 500
KRAGTYGALL MAAYSPEEDV FKTVCKMGSG FTDEELARMP KLLEDYKIDH
510 520 530 540 550
KHPSVISNIE ADVYFVPVKV AQVLGDEITL SPTHTCGWNK VRKNAGLAIR
560 570 580 590
FPRFMGWRDD KGPQDATTEE EIIEMYKEQL KVVEVEETKS EEEA
Length:594
Mass (Da):67,657
Last modified:April 29, 2008 - v1
Checksum:i662A34BCFC2A573E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000968 Genomic DNA Translation: ACB07131.1
RefSeqiWP_012309028.1, NC_010482.1

Genome annotation databases

EnsemblBacteriaiACB07131; ACB07131; Kcr_0375
GeneIDi6093662
KEGGikcr:Kcr_0375

Similar proteinsi

Entry informationi

Entry nameiDNLI2_KORCO
AccessioniPrimary (citable) accession number: B1L3V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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