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B1L3V2

- DNLI2_KORCO

UniProt

B1L3V2 - DNLI2_KORCO

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Protein
DNA ligase 2
Gene
lig2, Kcr_0375
Organism
Korarchaeum cryptofilum (strain OPF8)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei250 – 2501ATP By similarity
Active sitei252 – 2521N6-AMP-lysine intermediate By similarity
Binding sitei257 – 2571ATP By similarity
Binding sitei273 – 2731ATP By similarity
Binding sitei303 – 3031ATP By similarity
Binding sitei343 – 3431ATP By similarity
Binding sitei419 – 4191ATP By similarity
Binding sitei425 – 4251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciKCRY374847:GH12-378-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene namesi
Name:lig2
Ordered Locus Names:Kcr_0375
OrganismiKorarchaeum cryptofilum (strain OPF8)
Taxonomic identifieri374847 [NCBI]
Taxonomic lineageiArchaeaKorarchaeotaCandidatus Korarchaeum
ProteomesiUP000001686: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594DNA ligase 2UniRule annotation
PRO_0000365250Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi374847.Kcr_0375.

Structurei

3D structure databases

ProteinModelPortaliB1L3V2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiLDPSGYN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1L3V2-1 [UniParc]FASTAAdd to Basket

« Hide

MNFIDVAKIY EKIEATTGRL EMIDYLKNLF LSTPPEILDK IVYLTLGNIA    50
ASFEGIELGV GEKLFLRALS LATGIPQERL EEEYPKLGDI GKLAEWAVSK 100
KAAQSFFTED LTVERVFDTL SKVARATGEG AQDLKVRLIA GILSDAKPLE 150
ARYIARIVTE KLRLGVRDMT VLDALSEAFL KGRAYRDKLE RKYNIYPDIG 200
KIAKVVAEKG IKGLDEITIT LGIPVRPMLA QRLRSAEEIM EKIGPRIFAE 250
FKYDGERMQI HVWKDGKVKI FSRRLEDITE PYPDVREYVS KAVEGHEVVL 300
DCETVAINPD TGEILPFQEL MHRRRKYGVE EAMKTYPTVT YAFDLLYLDG 350
RELLDEQLDD RRKILKEILK ENEKARLVQY EEIDGNVEEL ERFFEHAVEM 400
GTEGLVVKDP KSIYQAGVRG WSWIKLKRSY ISKMIEPVDL VVVGAFWGKG 450
KRAGTYGALL MAAYSPEEDV FKTVCKMGSG FTDEELARMP KLLEDYKIDH 500
KHPSVISNIE ADVYFVPVKV AQVLGDEITL SPTHTCGWNK VRKNAGLAIR 550
FPRFMGWRDD KGPQDATTEE EIIEMYKEQL KVVEVEETKS EEEA 594
Length:594
Mass (Da):67,657
Last modified:April 29, 2008 - v1
Checksum:i662A34BCFC2A573E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07131.1.
RefSeqiYP_001736814.1. NC_010482.1.

Genome annotation databases

EnsemblBacteriaiACB07131; ACB07131; Kcr_0375.
GeneIDi6093662.
KEGGikcr:Kcr_0375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000968 Genomic DNA. Translation: ACB07131.1 .
RefSeqi YP_001736814.1. NC_010482.1.

3D structure databases

ProteinModelPortali B1L3V2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 374847.Kcr_0375.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACB07131 ; ACB07131 ; Kcr_0375 .
GeneIDi 6093662.
KEGGi kcr:Kcr_0375.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi LDPSGYN.

Enzyme and pathway databases

BioCyci KCRY374847:GH12-378-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: OPF8.

Entry informationi

Entry nameiDNLI2_KORCO
AccessioniPrimary (citable) accession number: B1L3V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi