B1L3H1 (B1L3H1_KORCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224

Gene names

Name:	pyrD HAMAP MF_00224
Ordered Locus Names:	Kcr_0240

Organism

Korarchaeum cryptofilum (strain OPF8)

Taxonomic identifier

374847 [NCBI]

Taxonomic lineage

Archaea › Korarchaeota › Candidatus Korarchaeum

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224
Catalytic activity	(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224
Cofactor	Binds 1 FMN per subunit By similarity. HAMAP MF_00224
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224
Subcellular location	Cytoplasm By similarity HAMAP MF_00224.
Sequence similarities	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis HAMAP MF_00224
Cellular component	Cytoplasm HAMAP MF_00224
Ligand	FMN HAMAP MF_00224 Flavoprotein HAMAP MF_00224
Molecular function	Oxidoreductase HAMAP MF_00224
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	104	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	B1L3H1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 8A98822BC9BA013A	FASTA	275	29,368
	10 20 30 40 50 60 MTPSLLKRVE RAGAGAVTTK TILPRPSRGY ENPVVVELPF GMLNAMGLPN PGIDEFEREF 70 80 90 100 110 120 REARGSIEIP VIGSAGGNTP EEVAYVAGRL QDCGVDAVEL NASCPHVRGH GLEVGSTPEL 130 140 150 160 170 180 MRELVSEVRR NVKIPIIVKL SPMVPDIASL GRSAFESGAD ALNAINTVRA MYIDVEAMTP 190 200 210 220 230 240 VLSNKFGGLS GPAIRPIAVR CVYELAGICD VIGTGGVETW RDAVEMMLAG AKAVGIGTAI 250 260 270 YRRGLEVFEE INRGLESYLL KKGLSLREII GRARG

References

[1]

"A korarchaeal genome reveals new insights into the evolution of the Archaea." Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O. Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed: 18535141] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: OPF8.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000968 Genomic DNA. Translation: ACB07000.1.
RefSeq	YP_001736683.1. NC_010482.1.
3D structure databases
ProteinModelPortal	B1L3H1.
ModBase	Search...
Protein-protein interaction databases
STRING	B1L3H1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6093529.
GenomeReviews	Gene locus Kcr_0240 in contig CP000968_GR.
KEGG	kcr:Kcr_0240.
Phylogenomic databases
HOGENOM	HBG472415.
OMA	VALRMVW.
PhylomeDB	B1L3H1.
Family and domain databases
HAMAP	MF_00224. DHO_dh_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR024920. Dihydroorotate_DH_1. IPR012135. Dihydroorotate_DH_1_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01037. PyrD_sub1_fam. 1 hit.
PROSITE	PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1L3H1_KORCO

Accession

Primary (citable) accession number: B1L3H1

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)