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B1L3E4 (SYR_KORCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Kcr_0213
OrganismKorarchaeum cryptofilum (strain OPF8) [Reference proteome] [HAMAP]
Taxonomic identifier374847 [NCBI]
Taxonomic lineageArchaeaKorarchaeotaCandidatus Korarchaeum

Protein attributes

Sequence length632 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 632632Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000095374

Regions

Motif129 – 13911"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
B1L3E4 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 751ACAF493D4691C

FASTA63271,667
        10         20         30         40         50         60 
MIKDPLGAVK STFAEEVNRV LRDLGSATRF SPIQVSRVRK DYASYGLPVG FKVAKDLNLD 

        70         80         90        100        110        120 
PERAAKTVLD RIDMSRIAYS SDAYAESGYL NLRIDKARFF RDILKLASSE ELGRGERKGV 

       130        140        150        160        170        180 
VGMVEHTSAN PVHPLHVGSG RNAVIGDSFS RILNFLGWDV RRHYLVNDCN LQVAILAAGR 

       190        200        210        220        230        240 
SKVRDLIPKG KVDHWFGLIY AISNAFLEIW RIKNGFNSES KIEEWSEVVE RIGRMEPELL 

       250        260        270        280        290        300 
RIGELSEEEV MSLLREYQRK EGGSVQMFRE ITESVLRGFV ETLERMGITY DSFDRESELI 

       310        320        330        340        350        360 
WDGWVDRAIE KLESSGYLKR EGKAAYVDLW EAAKGDENVR KVFELSEDDI SKLEREGKLG 

       370        380        390        400        410        420 
EVIPRKFYLT RSDGTWLYTG TDVAYSLYKF DGLGVSFCYN VIASEQNMEQ KGVRACLALM 

       430        440        450        460        470        480 
GHDPGKLIHL SYEMVNLVGA AMSGRRGLYI TLDEVLDEAK RRVEAILKER GIYDEEICEK 

       490        500        510        520        530        540 
VAIGALKYGL ISVSPNKVVQ FRWERVLNLE ENSGPFIQYA YTRALNIIKK AQGVPEDFDP 

       550        560        570        580        590        600 
NELKSDAEIT IVQMISEFPE RVWSAFNLMR PDIIASYANE LASQFNKFYE DHPVLSAARP 

       610        620        630 
EERAARLNLV NAVKGTLGLA MDLIGIPRLE RM 

« Hide

References

[1]"A korarchaeal genome reveals new insights into the evolution of the Archaea."
Elkins J.G., Podar M., Graham D.E., Makarova K.S., Wolf Y., Randau L., Hedlund B.P., Brochier-Armanet C., Kunin V., Anderson I., Lapidus A., Goltsman E., Barry K., Koonin E.V., Hugenholtz P., Kyrpides N., Wanner G., Richardson P., Keller M., Stetter K.O.
Proc. Natl. Acad. Sci. U.S.A. 105:8102-8107(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: OPF8.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000968 Genomic DNA. Translation: ACB06973.1.
RefSeqYP_001736656.1. NC_010482.1.

3D structure databases

ProteinModelPortalB1L3E4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING374847.Kcr_0213.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACB06973; ACB06973; Kcr_0213.
GeneID6093502.
KEGGkcr:Kcr_0213.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMADGTAVYM.

Enzyme and pathway databases

BioCycKCRY374847:GH12-218-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_KORCO
AccessionPrimary (citable) accession number: B1L3E4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries