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B1KYY3

- GLSA_CLOBM

UniProt

B1KYY3 - GLSA_CLOBM

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Protein
Glutaminase
Gene
glsA, CLK_2195
Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei158 – 1581Substrate By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei189 – 1891Substrate By similarity
Binding sitei241 – 2411Substrate By similarity
Binding sitei259 – 2591Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCBOT498214:GH05-2846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:CLK_2195
OrganismiClostridium botulinum (strain Loch Maree / Type A3)
Taxonomic identifieri498214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000722: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305GlutaminaseUniRule annotation
PRO_1000115696Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi498214.CLK_2195.

Structurei

3D structure databases

ProteinModelPortaliB1KYY3.
SMRiB1KYY3. Positions 3-305.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiMMDVSQI.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KYY3-1 [UniParc]FASTAAdd to Basket

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MNRLLKTVIE NNRKWISEGK VASYIPELSK MDKNLLGISV CTLGGEEYWE    50
GDAEVKFTIQ SISKIVTLML AIIDNGEDYV FSKVGMEPTE TAFNSIVNLE 100
AKESHKPINP MINAGAIVVA SMVAGKDSDE KFDRILKFTR KISGNNNIDI 150
NLNVYTSEKE TGHRNRALAY FMKSTGALKG DVEEILDVYF KQCSIEITCK 200
DLARIGVMLA NDGVSPYTGD RIVPRYVARI VKTIMVTCGM YDASGNFAVH 250
IGIPAKSGVG GGIVACAPRR MGIGVLGTAL DEKGNSIAGT KILEELSKQL 300
DLSIF 305
Length:305
Mass (Da):33,256
Last modified:April 29, 2008 - v1
Checksum:iA2698EC8D5B683A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000962 Genomic DNA. Translation: ACA56877.1.
RefSeqiYP_001788126.1. NC_010520.1.

Genome annotation databases

EnsemblBacteriaiACA56877; ACA56877; CLK_2195.
GeneIDi6151943.
KEGGicbl:CLK_2195.
PATRICi19390994. VBICloBot822_3110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000962 Genomic DNA. Translation: ACA56877.1 .
RefSeqi YP_001788126.1. NC_010520.1.

3D structure databases

ProteinModelPortali B1KYY3.
SMRi B1KYY3. Positions 3-305.
ModBasei Search...

Protein-protein interaction databases

STRINGi 498214.CLK_2195.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA56877 ; ACA56877 ; CLK_2195 .
GeneIDi 6151943.
KEGGi cbl:CLK_2195.
PATRICi 19390994. VBICloBot822_3110.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi MMDVSQI.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci CBOT498214:GH05-2846-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Loch Maree / Type A3.

Entry informationi

Entry nameiGLSA_CLOBM
AccessioniPrimary (citable) accession number: B1KYY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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