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B1KYY3

- GLSA_CLOBM

UniProt

B1KYY3 - GLSA_CLOBM

Protein

Glutaminase

Gene

glsA

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei61 – 611SubstrateUniRule annotation
    Binding sitei113 – 1131SubstrateUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation
    Binding sitei189 – 1891SubstrateUniRule annotation
    Binding sitei241 – 2411SubstrateUniRule annotation
    Binding sitei259 – 2591Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciCBOT498214:GH05-2846-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:CLK_2195
    OrganismiClostridium botulinum (strain Loch Maree / Type A3)
    Taxonomic identifieri498214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000722: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305GlutaminasePRO_1000115696Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi498214.CLK_2195.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KYY3.
    SMRiB1KYY3. Positions 3-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiMMDVSQI.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1KYY3-1 [UniParc]FASTAAdd to Basket

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    MNRLLKTVIE NNRKWISEGK VASYIPELSK MDKNLLGISV CTLGGEEYWE    50
    GDAEVKFTIQ SISKIVTLML AIIDNGEDYV FSKVGMEPTE TAFNSIVNLE 100
    AKESHKPINP MINAGAIVVA SMVAGKDSDE KFDRILKFTR KISGNNNIDI 150
    NLNVYTSEKE TGHRNRALAY FMKSTGALKG DVEEILDVYF KQCSIEITCK 200
    DLARIGVMLA NDGVSPYTGD RIVPRYVARI VKTIMVTCGM YDASGNFAVH 250
    IGIPAKSGVG GGIVACAPRR MGIGVLGTAL DEKGNSIAGT KILEELSKQL 300
    DLSIF 305
    Length:305
    Mass (Da):33,256
    Last modified:April 29, 2008 - v1
    Checksum:iA2698EC8D5B683A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA56877.1.
    RefSeqiYP_001788126.1. NC_010520.1.

    Genome annotation databases

    EnsemblBacteriaiACA56877; ACA56877; CLK_2195.
    GeneIDi6151943.
    KEGGicbl:CLK_2195.
    PATRICi19390994. VBICloBot822_3110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA56877.1 .
    RefSeqi YP_001788126.1. NC_010520.1.

    3D structure databases

    ProteinModelPortali B1KYY3.
    SMRi B1KYY3. Positions 3-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498214.CLK_2195.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA56877 ; ACA56877 ; CLK_2195 .
    GeneIDi 6151943.
    KEGGi cbl:CLK_2195.
    PATRICi 19390994. VBICloBot822_3110.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi MMDVSQI.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci CBOT498214:GH05-2846-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Loch Maree / Type A3.

    Entry informationi

    Entry nameiGLSA_CLOBM
    AccessioniPrimary (citable) accession number: B1KYY3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3