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B1KXQ3 (OTC_CLOBM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3
Gene names
Name:arcB
Ordered Locus Names:CLK_1978
OrganismClostridium botulinum (strain Loch Maree / Type A3) [Complete proteome] [HAMAP]
Taxonomic identifier498214 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm By similarity HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Ornithine carbamoyltransferase HAMAP MF_01109
PRO_1000137092

Regions

Region56 – 605Carbamoyl phosphate binding By similarity
Region272 – 2754Ornithine binding By similarity

Sites

Binding site1071Carbamoyl phosphate By similarity
Binding site1341Carbamoyl phosphate By similarity
Site311Important for structural integrity By similarity
Site1471Important for structural integrity By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KXQ3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 0F4E4F5E8F8D217E

FASTA33337,252
        10         20         30         40         50         60 
MFNLKNRNFL TLMDFTPKEI NYFLDLARDL KRAKYTGTEV QRMKGKNIAL IFEKASTRTR 

        70         80         90        100        110        120 
CAFEVGAKDQ GAHVTYLGPT GSHIGKKESA ADTARVLGRM YDGIEYRGFG QEIVETLAEY 

       130        140        150        160        170        180 
AGVPVWNGLT DEDHPTQILA DFLTIREHFN KPLSEIKFAY VGDGANNMAN ALMIGAVKMG 

       190        200        210        220        230        240 
MDFRIVSPKE IPTDATLVAK CKEIAAETGA KVTITDNIEE GVKGCDVLYT DVWVSMGEPD 

       250        260        270        280        290        300 
SVWESKIKLL TPYRVDMNMI KMTGNPDAKF MHCLPAFHDE ETAVGKEIKE KYGLSEMEVS 

       310        320        330 
HELFESKYSI VFDEAENRMH TIKAVMVATL GDQ

« Hide

References

[1]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Loch Maree / Type A3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000962 Genomic DNA. Translation: ACA56830.1.
RefSeqYP_001787911.1. NC_010520.1.

3D structure databases

ProteinModelPortalB1KXQ3.
SMRB1KXQ3. Positions 2-332.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1KXQ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6152089.
GenomeReviewsGene locus CLK_1978 in contig CP000962_GR.
KEGGcbl:CLK_1978.
PATRIC19390556. VBICloBot822_2891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMAMTPYQIN.
ProtClustDBPRK04284.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P-bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn-bd.
IPR002292. Orn/put_carbamltrans.
IPR024904. Orn_carbamltrans.
[Graphical view]
KOK00611.
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
SUPFAMSSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMsTIGR00658. Orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTC_CLOBM
AccessionPrimary (citable) accession number: B1KXQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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