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B1KWD8

- B1KWD8_CLOBM

UniProt

B1KWD8 - B1KWD8_CLOBM

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCBOT498214:GH05-763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotationImported
    Ordered Locus Names:CLK_0100Imported
    OrganismiClostridium botulinum (strain Loch Maree / Type A3)Imported
    Taxonomic identifieri498214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000722: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei272 – 2721N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi498214.CLK_0100.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KWD8.
    SMRiB1KWD8. Positions 6-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1KWD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDYNKVIFE LSSEGRKGYR LPDLDVPEVE LSKLLPKNLL REDEIELPEV    50
    SEVDVVRHYT ALSNKNYTVD NGFYPLGSCT MKYNPKINED IVALSGFSKI 100
    HPLQDENISQ GALELMYDLK GKLCEITGLD DFTLQPAAGA HGEYTGLLII 150
    KAYHEKRGDT KRTKIIVPDS AHGTNPASAS VAGFDIVEIK SGEDGRVSIE 200
    ELKKVLNDEI AGLMLTNPST LGLFEKDIKL ISELVHEAGG LLYYDGANLN 250
    AIMGIARPGD MGFDVCHLNM HKTFSTPHGG GGPGSGPVGV KKHLAKFLPV 300
    PTVEKENDKF ILDYNREDSL GKIRSLYGNF GVMVKAYTYI LTMGKEGLKS 350
    ASENAVLNAN YIKESLRDYY NIGKDDICKH EVILSTLKEN PHHIATLDIA 400
    KRLIDYGVHP PTVYFPLIIE EALMIEPTES ESKETVDEFI DAMKKIAVEA 450
    KENPELLHEA PVKAPVRRLD QVKAARKPIL RWQK 484
    Length:484
    Mass (Da):53,762
    Last modified:April 29, 2008 - v1
    Checksum:i858671CD922F0D66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA56785.1.
    RefSeqiWP_012344606.1. NC_010520.1.
    YP_001786051.1. NC_010520.1.

    Genome annotation databases

    EnsemblBacteriaiACA56785; ACA56785; CLK_0100.
    GeneIDi6152085.
    KEGGicbl:CLK_0100.
    PATRICi19386837. VBICloBot822_1032.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA56785.1 .
    RefSeqi WP_012344606.1. NC_010520.1.
    YP_001786051.1. NC_010520.1.

    3D structure databases

    ProteinModelPortali B1KWD8.
    SMRi B1KWD8. Positions 6-484.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498214.CLK_0100.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA56785 ; ACA56785 ; CLK_0100 .
    GeneIDi 6152085.
    KEGGi cbl:CLK_0100.
    PATRICi 19386837. VBICloBot822_1032.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci CBOT498214:GH05-763-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Loch Maree / Type A3Imported.

    Entry informationi

    Entry nameiB1KWD8_CLOBM
    AccessioniPrimary (citable) accession number: B1KWD8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3