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B1KWD8

- B1KWD8_CLOBM

UniProt

B1KWD8 - B1KWD8_CLOBM

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, CLK_0100
Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCBOT498214:GH05-763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPBUniRule annotationImported
Ordered Locus Names:CLK_0100Imported
OrganismiClostridium botulinum (strain Loch Maree / Type A3)Imported
Taxonomic identifieri498214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000722: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi498214.CLK_0100.

Structurei

3D structure databases

ProteinModelPortaliB1KWD8.
SMRiB1KWD8. Positions 6-484.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KWD8-1 [UniParc]FASTAAdd to Basket

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MKDYNKVIFE LSSEGRKGYR LPDLDVPEVE LSKLLPKNLL REDEIELPEV    50
SEVDVVRHYT ALSNKNYTVD NGFYPLGSCT MKYNPKINED IVALSGFSKI 100
HPLQDENISQ GALELMYDLK GKLCEITGLD DFTLQPAAGA HGEYTGLLII 150
KAYHEKRGDT KRTKIIVPDS AHGTNPASAS VAGFDIVEIK SGEDGRVSIE 200
ELKKVLNDEI AGLMLTNPST LGLFEKDIKL ISELVHEAGG LLYYDGANLN 250
AIMGIARPGD MGFDVCHLNM HKTFSTPHGG GGPGSGPVGV KKHLAKFLPV 300
PTVEKENDKF ILDYNREDSL GKIRSLYGNF GVMVKAYTYI LTMGKEGLKS 350
ASENAVLNAN YIKESLRDYY NIGKDDICKH EVILSTLKEN PHHIATLDIA 400
KRLIDYGVHP PTVYFPLIIE EALMIEPTES ESKETVDEFI DAMKKIAVEA 450
KENPELLHEA PVKAPVRRLD QVKAARKPIL RWQK 484
Length:484
Mass (Da):53,762
Last modified:April 29, 2008 - v1
Checksum:i858671CD922F0D66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000962 Genomic DNA. Translation: ACA56785.1.
RefSeqiWP_012344606.1. NC_010520.1.
YP_001786051.1. NC_010520.1.

Genome annotation databases

EnsemblBacteriaiACA56785; ACA56785; CLK_0100.
GeneIDi6152085.
KEGGicbl:CLK_0100.
PATRICi19386837. VBICloBot822_1032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000962 Genomic DNA. Translation: ACA56785.1 .
RefSeqi WP_012344606.1. NC_010520.1.
YP_001786051.1. NC_010520.1.

3D structure databases

ProteinModelPortali B1KWD8.
SMRi B1KWD8. Positions 6-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498214.CLK_0100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA56785 ; ACA56785 ; CLK_0100 .
GeneIDi 6152085.
KEGGi cbl:CLK_0100.
PATRICi 19386837. VBICloBot822_1032.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci CBOT498214:GH05-763-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Loch Maree / Type A3.

Entry informationi

Entry nameiB1KWD8_CLOBM
AccessioniPrimary (citable) accession number: B1KWD8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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