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B1KTP9

- B1KTP9_CLOBM

UniProt

B1KTP9 - B1KTP9_CLOBM

Protein

Alanine racemase

Gene

alr

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei144 – 1441SubstrateUniRule annotation
    Active sitei275 – 2751Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei328 – 3281Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCBOT498214:GH05-316-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:CLK_3463Imported
    OrganismiClostridium botulinum (strain Loch Maree / Type A3)Imported
    Taxonomic identifieri498214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000722: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi498214.CLK_3463.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KTP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000031444.
    KOiK01775.
    OMAiISHFACA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1KTP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFEHSRPAWI EINLDNLIHN MKEIRRVARS KEIISVVKAD AYGHGALEIA    50
    SLLLENGANR LAVAVLSEAL ELRNNGITAP IIILGYTPLR YDEKTICNNA 100
    ETIIKNDLEV SVSSYKYAEQ LSKKAQQLGK DVKIHVNIDT GMGRLGFLPT 150
    EENLEKIYQI SKLPNIIFEG LFSHFSTADE KNKDYTNEQF KKFLDFYYKL 200
    RDKNVKVNIK HIANSAALID LPYTHLDAVR PGIAQYGYYP SSEVNHKDIN 250
    LRPIMTLKTN IVLVKDIKSG QSISYGRKFR TIRNSKIAVL PIGYADGYER 300
    ELSNENNVYK AQVIVNGRRA PIVGRITMDM CMIDVTDIGD VKVGDEVILI 350
    GECNDERISV EDIADLLNTI PYEVTSRISK RIPRYYMKDG KIVKISQINK 400
    EVNK 404
    Length:404
    Mass (Da):45,827
    Last modified:April 29, 2008 - v1
    Checksum:i08F9BC365E395B72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA53599.1.
    RefSeqiYP_001785612.1. NC_010520.1.

    Genome annotation databases

    EnsemblBacteriaiACA53599; ACA53599; CLK_3463.
    GeneIDi6152627.
    KEGGicbl:CLK_3463.
    PATRICi19385945. VBICloBot822_0593.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA53599.1 .
    RefSeqi YP_001785612.1. NC_010520.1.

    3D structure databases

    ProteinModelPortali B1KTP9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498214.CLK_3463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA53599 ; ACA53599 ; CLK_3463 .
    GeneIDi 6152627.
    KEGGi cbl:CLK_3463.
    PATRICi 19385945. VBICloBot822_0593.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000031444.
    KOi K01775.
    OMAi ISHFACA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CBOT498214:GH05-316-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Loch Maree / Type A3Imported.

    Entry informationi

    Entry nameiB1KTP9_CLOBM
    AccessioniPrimary (citable) accession number: B1KTP9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3