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B1KTJ6

- TPIS_CLOBM

UniProt

B1KTJ6 - TPIS_CLOBM

Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei9 – 91SubstrateUniRule annotation
    Binding sitei11 – 111SubstrateUniRule annotation
    Active sitei94 – 941ElectrophileUniRule annotation
    Active sitei166 – 1661Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP
    3. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis, Pentose shunt

    Enzyme and pathway databases

    BioCyciCBOT498214:GH05-263-MONOMER.
    UniPathwayiUPA00109; UER00189.
    UPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
    Short name:
    TIMUniRule annotation
    Alternative name(s):
    Triose-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:tpiAUniRule annotation
    Ordered Locus Names:CLK_3410
    OrganismiClostridium botulinum (strain Loch Maree / Type A3)
    Taxonomic identifieri498214 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000722: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 248248Triosephosphate isomerasePRO_1000096489Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi498214.CLK_3410.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KTJ6.
    SMRiB1KTJ6. Positions 2-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the triosephosphate isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0149.
    HOGENOMiHOG000226413.
    KOiK01803.
    OMAiICAPFTA.
    OrthoDBiEOG66QM23.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00147_B. TIM_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view]
    PANTHERiPTHR21139. PTHR21139. 1 hit.
    PfamiPF00121. TIM. 1 hit.
    [Graphical view]
    SUPFAMiSSF51351. SSF51351. 1 hit.
    TIGRFAMsiTIGR00419. tim. 1 hit.
    PROSITEiPS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1KTJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTAIIAGNW KMNKTVKEAV ELVKELKPLV KDAKCDVVVC PTYVCLPAVL    50
    EEVKGSNIKV GAQNMHFEES GAYTGEISPK MLEELGVHYV IIGHSERRQY 100
    FNETDETVNK KVKKAFEHNL IPIVCCGESL EQREGNVTEK VLEGQIKVDL 150
    KELSKEQVEK LVIAYEPIWA IGTGKTATDE QANETIGYIR TVVKSMYGED 200
    VASKVRIQYG GSVKPGTIKA QMAKEEIDGA LVGGASLKAE DFSAIVNF 248
    Length:248
    Mass (Da):27,337
    Last modified:April 29, 2008 - v1
    Checksum:i26FC0B31EAE7BBF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA56414.1.
    RefSeqiWP_012344289.1. NC_010520.1.
    YP_001785559.1. NC_010520.1.

    Genome annotation databases

    EnsemblBacteriaiACA56414; ACA56414; CLK_3410.
    GeneIDi6153595.
    KEGGicbl:CLK_3410.
    PATRICi19385839. VBICloBot822_0540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000962 Genomic DNA. Translation: ACA56414.1 .
    RefSeqi WP_012344289.1. NC_010520.1.
    YP_001785559.1. NC_010520.1.

    3D structure databases

    ProteinModelPortali B1KTJ6.
    SMRi B1KTJ6. Positions 2-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498214.CLK_3410.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA56414 ; ACA56414 ; CLK_3410 .
    GeneIDi 6153595.
    KEGGi cbl:CLK_3410.
    PATRICi 19385839. VBICloBot822_0540.

    Phylogenomic databases

    eggNOGi COG0149.
    HOGENOMi HOG000226413.
    KOi K01803.
    OMAi ICAPFTA.
    OrthoDBi EOG66QM23.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00189 .
    UPA00138 .
    BioCyci CBOT498214:GH05-263-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00147_B. TIM_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR022896. TrioseP_Isoase_bac/euk.
    IPR000652. Triosephosphate_isomerase.
    IPR020861. Triosephosphate_isomerase_AS.
    [Graphical view ]
    PANTHERi PTHR21139. PTHR21139. 1 hit.
    Pfami PF00121. TIM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51351. SSF51351. 1 hit.
    TIGRFAMsi TIGR00419. tim. 1 hit.
    PROSITEi PS00171. TIM_1. 1 hit.
    PS51440. TIM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
      Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
      PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Loch Maree / Type A3.

    Entry informationi

    Entry nameiTPIS_CLOBM
    AccessioniPrimary (citable) accession number: B1KTJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3