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B1KTJ5

- PGK_CLOBM

UniProt

B1KTJ5 - PGK_CLOBM

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei155 – 1551SubstrateUniRule annotation
Binding sitei206 – 2061ATPUniRule annotation
Binding sitei297 – 2971ATP; via carbonyl oxygenUniRule annotation
Binding sitei328 – 3281ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi354 – 3574ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBOT498214:GH05-262-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:CLK_3409
OrganismiClostridium botulinum (strain Loch Maree / Type A3)
Taxonomic identifieri498214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000722: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Phosphoglycerate kinasePRO_1000096333Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi498214.CLK_3409.

Structurei

3D structure databases

ProteinModelPortaliB1KTJ5.
SMRiB1KTJ5. Positions 4-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 253Substrate bindingUniRule annotation
Regioni61 – 644Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiWEALDIG.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KTJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYNKKSIED IDVKSKKVLV RCDFNVPLNE GKITDENRLV GALPTVKYLM
60 70 80 90 100
EKGAKIILCS HMGKPKGEPK KELSLLPVAK RLSEMLNKEV VFADDDNVVG
110 120 130 140 150
ENAKKAVEDM KDGDIVLLQN TRYRKEETKN EEIFSKELAS LADVFVNDAF
160 170 180 190 200
GTAHRAHCST VGVTHYLKEA ACGYLIQKEL KFLGNAVETP ERPFVAILGG
210 220 230 240 250
AKVSDKINVI NNLLDKVDTL IIGGGMGYTF LKSLGYTVGD SLLEEDKVEY
260 270 280 290 300
AKEMINKAKE KGVNFLLPVD ITIADRFDKD AEPIVTEDQN VKEGYMGLDI
310 320 330 340 350
GSKTAKIYAD AIKSAKTVIW NGPMGVFEFK NFANGTIEVA KAMADSDAVT
360 370 380 390
IIGGGDSAAA VNIFGFGDKM SHISTGGGAS LEFLEGKELP GIAALNDK
Length:398
Mass (Da):43,271
Last modified:April 29, 2008 - v1
Checksum:i4AE9CBAA10E72F37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA. Translation: ACA55850.1.
RefSeqiWP_012343779.1. NC_010520.1.
YP_001785558.1. NC_010520.1.

Genome annotation databases

EnsemblBacteriaiACA55850; ACA55850; CLK_3409.
GeneIDi6153599.
KEGGicbl:CLK_3409.
PATRICi19385837. VBICloBot822_0539.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA. Translation: ACA55850.1 .
RefSeqi WP_012343779.1. NC_010520.1.
YP_001785558.1. NC_010520.1.

3D structure databases

ProteinModelPortali B1KTJ5.
SMRi B1KTJ5. Positions 4-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498214.CLK_3409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA55850 ; ACA55850 ; CLK_3409 .
GeneIDi 6153599.
KEGGi cbl:CLK_3409.
PATRICi 19385837. VBICloBot822_0539.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi WEALDIG.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci CBOT498214:GH05-262-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
    Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
    PLoS ONE 2:E1271-E1271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Loch Maree / Type A3.

Entry informationi

Entry nameiPGK_CLOBM
AccessioniPrimary (citable) accession number: B1KTJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3