B1KTF5 (COMB_CLOBM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 2-phosphosulfolactate phosphatase
EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	CLK_3023

Organism

Clostridium botulinum (strain Loch Maree / Type A3) [Complete proteome] [HAMAP]

Taxonomic identifier

498214 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity. HAMAP MF_00490
Sequence similarities	Belongs to the ComB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000126225

Sequences

	Sequence		Length	Mass (Da)
	B1KTF5 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: BC84FC69E7799D5C	FASTA	239	26,689
	10 20 30 40 50 60 MNIDIVISAD HIDEKRLIKK TVIIIDILRA TSVITTAINN GCKKVIPVLT VEEAKDIAKN 70 80 90 100 110 120 SKEDIILGGE RNALKIDGFN FSNSPLEYTK KYVEGKTVVL STTNGTRAIN NSFNAKTILI 130 140 150 160 170 180 SALINSKATA KAIDKLNEDL IIINSGTNGQ FSIDDFICSG YLIDCLYNIR KDLELSDIAK 190 200 210 220 230 TAHYIYTNNK DIESFVKKAT HYSRLKSLNL EKDLEYCFQK DIIGVVPQYK DGYIIKSNI

References

[1]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Loch Maree / Type A3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000962 Genomic DNA. Translation: ACA57100.1.
RefSeq	YP_001788893.1. NC_010520.1.
3D structure databases
ProteinModelPortal	B1KTF5.
SMR	B1KTF5. Positions 1-235.
ModBase	Search...
Protein-protein interaction databases
STRING	B1KTF5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6152520.
GenomeReviews	Gene locus CLK_3023 in contig CP000962_GR.
KEGG	cbl:CLK_3023.
PATRIC	19392642. VBICloBot822_3882.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG633644.
OMA	DFICSGY.
ProtClustDB	PRK00886.
Family and domain databases
HAMAP	MF_00490. ComB. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. IPR022995. Pase_ComB. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
KO	K05979.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
SUPFAM	SSF142823. SSF142823. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_CLOBM

Accession

Primary (citable) accession number: B1KTF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program