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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:CLK_1275
OrganismiClostridium botulinum (strain Loch Maree / Type A3)
Taxonomic identifieri498214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000722 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001220511 – 401Exodeoxyribonuclease 7 large subunitAdd BLAST401

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiDKIHRYL.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KT53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIKTLTVSQ LNRYVKNTLD ADFILNNASV KGEISNLKIH SSGHIYFSLK
60 70 80 90 100
DGGSKINCVM FKSYAYNLKF ALENGMDVVA LGNVSVYEKE GSYQLYVKDM
110 120 130 140 150
KREGIGDLYV AFEKLKEKLK EEGLFDDAHK KEIPKFSKKI GVITSPTGAA
160 170 180 190 200
IKDIINVTKR RNKGIELLIY PALVQGTDAS KTLIEGIKTL NKVEDVDIII
210 220 230 240 250
LARGGGSIEE LWAFNNEELA YAVYNSKKPI ITGVGHETDF TIIDFVSDRR
260 270 280 290 300
APTPSAAAEI AAFDREVLIN EILNYKYNIK NSMENIIKEK RNYLNLYKQK
310 320 330 340 350
IEANSPTNII ANEYRNIDNL KELLNMKIEG KLNKEKNNLS RLSSLLEAHN
360 370 380 390 400
PLNVLKKGYT LIEDEGNNLI TEKEALKELN KINIIFKDGR AKLSIKYIEE

F
Length:401
Mass (Da):45,338
Last modified:April 29, 2008 - v1
Checksum:i3BA2E1BA8E01FD25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA. Translation: ACA54518.1.
RefSeqiWP_012342614.1. NC_010520.1.

Genome annotation databases

EnsemblBacteriaiACA54518; ACA54518; CLK_1275.
KEGGicbl:CLK_1275.
PATRICi19389158. VBICloBot822_2192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA. Translation: ACA54518.1.
RefSeqiWP_012342614.1. NC_010520.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA54518; ACA54518; CLK_1275.
KEGGicbl:CLK_1275.
PATRICi19389158. VBICloBot822_2192.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiDKIHRYL.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_CLOBM
AccessioniPrimary (citable) accession number: B1KT53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.