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B1KT49 (B1KT49_CLOBM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
EC=2.2.1.7 HAMAP MF_00315
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase HAMAP MF_00315
Gene names
Name:dxs HAMAP MF_00315 EMBL ACA55976.1
Ordered Locus Names:CLK_1271
OrganismClostridium botulinum (strain Loch Maree / Type A3) [Complete proteome] [HAMAP]
Taxonomic identifier498214 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315 SAAS SAAS005477

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315 SAAS SAAS005477

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315 SAAS SAAS005477

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315 SAAS SAAS005477

Subunit structure

Homodimer By similarity. HAMAP MF_00315 SAAS SAAS005477

Sequence similarities

Belongs to the transketolase family. DXPS subfamily. HAMAP MF_00315

Sequences

Sequence LengthMass (Da)Tools
B1KT49 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 34D35437501B92D2

FASTA62268,748
        10         20         30         40         50         60 
MKMKNILDKY QDFDSIKSMS INELNQFSYE IREFLIDNVS KTGGHLASNL GVVELTLSIF 

        70         80         90        100        110        120 
NVFDLNKDKI IWDVGHQAYV HKILTGRKDK FNTLRQYGGL SGFPKKCESP YDAFETGHSS 

       130        140        150        160        170        180 
TSISAALGMA RARDIKGEDN KVIAVIGDGA LTGGMAFEAL NDLGFNKTDL IIILNDNQMS 

       190        200        210        220        230        240 
IAENVGGMSS YLSKVRLDPT YNKLKKEVNN TLNKIPNVGK GMARSLERVK NGIKQMIVPG 

       250        260        270        280        290        300 
MFFENLGIKY LGPIDGHDIK ELSKVMKMAK DIKGPVLIHT ITKKGKGYAY AEKKPDKFHS 

       310        320        330        340        350        360 
IGSFDCTSGE INSKACLSYS GVFGEELTKI GKEDKRVVAI TAAMKDGTGL RKFAETFPKR 

       370        380        390        400        410        420 
FFDVGIAEQH AVTLAAGIAT EGLKPVFAVY STFLQRAYDQ ILHDICIQNL PVVFAIDRAG 

       430        440        450        460        470        480 
IVGSDGETHQ GIFDLSYLSS LPNMTIIAPK CLEEMKPMLK WALNQNSPVA IRYPRGGDIK 

       490        500        510        520        530        540 
SLEMTPIKNM KKGKWEVICE EGDIAIIATG KMVQHAIIAR EKLKEYGIKS TIVNANFINP 

       550        560        570        580        590        600 
IDKELIKNFV KKGYKIVTVE DNVIKGGFGS LVLQYISELK ANNTVLNLGF KDKFVPHGST 

       610        620 
DILYKIEGLD PEGIVKNIIK II

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References

[1]"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids."
Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.
PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000962 Genomic DNA. Translation: ACA55976.1.
RefSeqYP_001787209.1. NC_010520.1.

3D structure databases

ProteinModelPortalB1KT49.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1KT49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6151786.
GenomeReviewsGene locus CLK_1271 in contig CP000962_GR.
KEGGcbl:CLK_1271.
PATRIC19389150. VBICloBot822_2188.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG571647.
OMARAHEFES.
ProtClustDBPRK05444.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. 1 hit.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1KT49_CLOBM
AccessionPrimary (citable) accession number: B1KT49
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info