B1KSD4 (B1KSD4_CLOBM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase HAMAP MF_00101
Short name=Holo-ACP synthase HAMAP MF_00101
EC=2.7.8.7 HAMAP MF_00101

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS HAMAP MF_00101

Gene names

Name:	acpS HAMAP MF_00101 EMBL ACA55121.1
Ordered Locus Names:	CLK_2833

Organism

Clostridium botulinum (strain Loch Maree / Type A3) [Complete proteome] [HAMAP]

Taxonomic identifier

498214 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	126 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family. HAMAP MF_00101

Ontologies

Keywords
Biological process	Fatty acid biosynthesis HAMAP MF_00101 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00101
Ligand	Magnesium HAMAP MF_00101 Metal-binding HAMAP MF_00101
Molecular function	Transferase HAMAP MF_00101 EMBL ACA55121.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	8	1	Magnesium By similarity HAMAP MF_00101
	Metal binding	56	1	Magnesium By similarity HAMAP MF_00101

Sequences

	Sequence		Length	Mass (Da)
	B1KSD4 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 3098F2C4A952B97C	FASTA	126	14,620
	10 20 30 40 50 60 MIYGIGTDIT EIRRIEKAIT RNKNFINKLF TKNEMDLWEK KNFKLEFIAG RFAAKEAVSK 70 80 90 100 110 120 ALGTGIRDFN FKDIEIINNE LGKPQVILKP KAEDIIRKIS KSYKIHLSIS HEKEYAIAYA LLEVFI

References

[1]

"Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids." Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C., Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S. PLoS ONE 2:E1271-E1271(2007) [PubMed: 18060065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000962 Genomic DNA. Translation: ACA55121.1.
RefSeq	YP_001788730.1. NC_010520.1.
3D structure databases
ProteinModelPortal	B1KSD4.
ModBase	Search...
Protein-protein interaction databases
STRING	B1KSD4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6151884.
GenomeReviews	Gene locus CLK_2833 in contig CP000962_GR.
KEGG	cbl:CLK_2833.
PATRIC	19392276. VBICloBot822_3720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734479.
OMA	NSSAIAY.
ProtClustDB	CLSK972423.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR000700. PAS-assoc_C. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
PROSITE	PS50113. PAC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1KSD4_CLOBM

Accession

Primary (citable) accession number: B1KSD4

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)