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Protein

Alanine racemase

Gene

alr

Organism
Clostridium botulinum (strain Loch Maree / Type A3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr), Alanine racemase (alr), Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei38Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Active sitei267Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei315Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CLK_2830Imported
OrganismiClostridium botulinum (strain Loch Maree / Type A3)Imported
Taxonomic identifieri498214 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000722 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliB1KSD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 374Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

B1KSD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRNLRAVWA EIDLDNLQHN LKQIKKICGN KEIIGVIKAN AYGHGSMEIA
60 70 80 90 100
PTLLENGVSR LAVAVLSEAM ELRMSGIKEP IMILGYTPCA LGDMLLDNDI
110 120 130 140 150
EQSVYSYNDA LELSKIAVLK RKILKIHIVV DTGMGRIGFL PTKESVEDVY
160 170 180 190 200
KISKLPNIQI EGVFSHFSSA DELDKDYTLY QMNNYNEFIN KLEEKNIQVH
210 220 230 240 250
IKHIANSAAI IDLESTHLDA VRAGIIMYGY YPSNYVLRNN IKLKPVMSLK
260 270 280 290 300
TSIVHIKKVS SGEYISYGRT FKTERESIIA TLPIGYADGY NRLLSNKGKV
310 320 330 340 350
IVNGKLAPVI GRVCMDQCMI DVTSIENLKV GDVVTIMGEE NGVSYTAEDI
360 370 380
ASQIGTISYE VICNVNKRVP RVYKKDGKII NVVNYV
Length:386
Mass (Da):43,131
Last modified:April 29, 2008 - v1
Checksum:i4BD65F0C7A5E5313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000962 Genomic DNA Translation: ACA54762.1
RefSeqiWP_012342826.1, NC_010520.1

Genome annotation databases

EnsemblBacteriaiACA54762; ACA54762; CLK_2830
KEGGicbl:CLK_2830

Similar proteinsi

Entry informationi

Entry nameiB1KSD1_CLOBM
AccessioniPrimary (citable) accession number: B1KSD1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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