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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103ElectrophileUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1
Binding sitei181Substrate; via amide nitrogenUniRule annotation1
Binding sitei220SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSWOO392500:G1GBD-3919-MONOMER
UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:Swoo_3565
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000002168 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000965331 – 260Triosephosphate isomeraseAdd BLAST260

Proteomic databases

PRIDEiB1KRR4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi392500.Swoo_3565

Structurei

3D structure databases

ProteinModelPortaliB1KRR4
SMRiB1KRR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 13Substrate bindingUniRule annotation3
Regioni241 – 242Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CP7 Bacteria
COG0149 LUCA
HOGENOMiHOG000226413
KOiK01803
OMAiIADCFGT
OrthoDBiPOG091H02GL

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_B TIM_B, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR022896 TrioseP_Isoase_bac/euk
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1KRR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRRPMVAG NWKMNGSAQL AQELFKKFAT KLQNDSAEVV LCPPTIYLES
60 70 80 90 100
VRQQLDANKE ALNGCLVRMG AQNLSQHDFG AYTGEVSGQM LKDSGCRYVI
110 120 130 140 150
IGHSERRRMY GETSDIVAEK FAAAQKHGLT PILCVGESGP AREARRTFEV
160 170 180 190 200
IAEELDVVIE KNGTMAFDNA IIAYEPLWAV GTGKSATPEQ AQEVHAFIRK
210 220 230 240 250
RLSEVSPFIG ENIRILYGGS VTPSNAADLF AQPDVDGGLI GGVSLNSTEF
260
LSLCSIAMSA
Length:260
Mass (Da):28,160
Last modified:April 29, 2008 - v1
Checksum:i2E2FD989D9EB2441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA Translation: ACA87829.1
RefSeqiWP_012326162.1, NC_010506.1

Genome annotation databases

EnsemblBacteriaiACA87829; ACA87829; Swoo_3565
KEGGiswd:Swoo_3565

Similar proteinsi

Entry informationi

Entry nameiTPIS_SHEWM
AccessioniPrimary (citable) accession number: B1KRR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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