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B1KRD4 (SPEA_SHEWM) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Swoo_2057
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP]
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000145604

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KRD4 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 0609B1DA84469D62

FASTA63771,154
        10         20         30         40         50         60 
MSNWSINDAR TGYNVNYWSQ GLYGISDEGE ATVSPDPTRP ECSIGLNELA KDMVKSGVNL 

        70         80         90        100        110        120 
PVLVRFPQIL HHRVNSLCQA FNQAIQKYQY QADYLLVYPI KVNQQQTVVE EILASQVEKE 

       130        140        150        160        170        180 
VPQLGLEAGS KPELMAVLAM AQKASSVIIC NGYKDIEYIR LALIGEKLGH KVYIVLEKLS 

       190        200        210        220        230        240 
ELKTVLEESK KLGVTPRLGL RVRLAFQGKG KWQASGGEKS KFGLSASQVL TVIESLKSEE 

       250        260        270        280        290        300 
MLDSLQLLHF HLGSQIANIR DIRQGVSEAG RFYCELQKLG ANVKCFDVGG GLAVDYDGTR 

       310        320        330        340        350        360 
SQSSSSMNYG LTEYANNIVS VLTDICNEYE QPMPRIISES GCYLTAHHAV LITDVIGTEA 

       370        380        390        400        410        420 
YKPEDIQPPA EDAPQLLHNM WHSWNEISGR ADQRALIEIY HDCQSDLTEV HSLFALGQLS 

       430        440        450        460        470        480 
LTDRAWAEQV NLRVCHELQG VMSSKYRFHR PIIDELTEKL ADKFFVNFSL FQSLPDAWGI 

       490        500        510        520        530        540 
DQVFPIMPLS GLDKAPERRA VMLDITCDSD GTIDQYVDGQ GIETTLPVPA WSAESPYLIG 

       550        560        570        580        590        600 
FFLVGAYQEI LGDMHNLFGD TNSAVIRLDD DGRTNIESVL AGDTVADVLR YVNLDAVSFM 

       610        620        630 
RTYEELVNKH IQEDERANIL EELQLGLKGY TYLEDFS 

« Hide

References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000961 Genomic DNA. Translation: ACA86341.1.
RefSeqYP_001760436.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KRD4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392500.Swoo_2057.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA86341; ACA86341; Swoo_2057.
GeneID6116320.
KEGGswd:Swoo_2057.
PATRIC23606515. VBISheWoo126588_2125.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycSWOO392500:GI2C-2103-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_SHEWM
AccessionPrimary (citable) accession number: B1KRD4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways