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B1KQZ0

- NADK_SHEWM

UniProt

B1KQZ0 - NADK_SHEWM

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Protein
NAD kinase
Gene
nadK, Swoo_3480
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptor By similarity
Binding sitei157 – 1571NAD By similarity
Binding sitei174 – 1741NAD By similarity
Binding sitei176 – 1761NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732NAD By similarity
Nucleotide bindingi146 – 1472NAD By similarity
Nucleotide bindingi187 – 1926NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-3595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Swoo_3480
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292NAD kinaseUniRule annotation
PRO_1000192518Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_3480.

Structurei

3D structure databases

ProteinModelPortaliB1KQZ0.
SMRiB1KQZ0. Positions 4-292.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KQZ0-1 [UniParc]FASTAAdd to Basket

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MPKAFQTIGL IGKPNHHGTN LTLKRLHHWL TMQGFEILVE ERVAAEMGPK    50
CNSVDLLELG DRCDLAIVVG GDGNMLGAAR VLARFDIGVI GVNRGNLGFL 100
TDLPPDSFEA ALGDVLEGKF ETEFRFLLET EVHRHGNMKS SNTAVNEAVL 150
HPGKVAHMIE FEVYIDNNFM YSQRADGMIV STPTGSTAYS LSAGGAILTP 200
NLEALILVPM FPHTLSSRPI VVDACSIIKL VVSPENGDNL EVSCDGHVML 250
PVLPGDEIII KRSHERLRLI HPKGHNYFHV LRNKLGWGSK LF 292
Length:292
Mass (Da):32,018
Last modified:April 29, 2008 - v1
Checksum:i6974C3CAC48E52A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA87746.1.
RefSeqiWP_012326080.1. NC_010506.1.
YP_001761841.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA87746; ACA87746; Swoo_3480.
GeneIDi6117812.
KEGGiswd:Swoo_3480.
PATRICi23609579. VBISheWoo126588_3591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA87746.1 .
RefSeqi WP_012326080.1. NC_010506.1.
YP_001761841.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KQZ0.
SMRi B1KQZ0. Positions 4-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_3480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA87746 ; ACA87746 ; Swoo_3480 .
GeneIDi 6117812.
KEGGi swd:Swoo_3480.
PATRICi 23609579. VBISheWoo126588_3591.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SWOO392500:GI2C-3595-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiNADK_SHEWM
AccessioniPrimary (citable) accession number: B1KQZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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