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B1KQZ0

- NADK_SHEWM

UniProt

B1KQZ0 - NADK_SHEWM

Protein

NAD kinase

Gene

nadK

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Proton acceptorUniRule annotation
    Binding sitei157 – 1571NADUniRule annotation
    Binding sitei174 – 1741NADUniRule annotation
    Binding sitei176 – 1761NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi72 – 732NADUniRule annotation
    Nucleotide bindingi146 – 1472NADUniRule annotation
    Nucleotide bindingi187 – 1926NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWOO392500:GI2C-3595-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Swoo_3480
    OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
    Taxonomic identifieri392500 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002168: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292NAD kinasePRO_1000192518Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392500.Swoo_3480.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KQZ0.
    SMRiB1KQZ0. Positions 4-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1KQZ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPKAFQTIGL IGKPNHHGTN LTLKRLHHWL TMQGFEILVE ERVAAEMGPK    50
    CNSVDLLELG DRCDLAIVVG GDGNMLGAAR VLARFDIGVI GVNRGNLGFL 100
    TDLPPDSFEA ALGDVLEGKF ETEFRFLLET EVHRHGNMKS SNTAVNEAVL 150
    HPGKVAHMIE FEVYIDNNFM YSQRADGMIV STPTGSTAYS LSAGGAILTP 200
    NLEALILVPM FPHTLSSRPI VVDACSIIKL VVSPENGDNL EVSCDGHVML 250
    PVLPGDEIII KRSHERLRLI HPKGHNYFHV LRNKLGWGSK LF 292
    Length:292
    Mass (Da):32,018
    Last modified:April 29, 2008 - v1
    Checksum:i6974C3CAC48E52A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA87746.1.
    RefSeqiWP_012326080.1. NC_010506.1.
    YP_001761841.1. NC_010506.1.

    Genome annotation databases

    EnsemblBacteriaiACA87746; ACA87746; Swoo_3480.
    GeneIDi6117812.
    KEGGiswd:Swoo_3480.
    PATRICi23609579. VBISheWoo126588_3591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA87746.1 .
    RefSeqi WP_012326080.1. NC_010506.1.
    YP_001761841.1. NC_010506.1.

    3D structure databases

    ProteinModelPortali B1KQZ0.
    SMRi B1KQZ0. Positions 4-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392500.Swoo_3480.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA87746 ; ACA87746 ; Swoo_3480 .
    GeneIDi 6117812.
    KEGGi swd:Swoo_3480.
    PATRICi 23609579. VBISheWoo126588_3591.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci SWOO392500:GI2C-3595-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51908 / MS32.

    Entry informationi

    Entry nameiNADK_SHEWM
    AccessioniPrimary (citable) accession number: B1KQZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3