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B1KQZ0

- NADK_SHEWM

UniProt

B1KQZ0 - NADK_SHEWM

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Protein

NAD kinase

Gene

nadK

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721Proton acceptorUniRule annotation
Binding sitei157 – 1571NADUniRule annotation
Binding sitei174 – 1741NADUniRule annotation
Binding sitei176 – 1761NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732NADUniRule annotation
Nucleotide bindingi146 – 1472NADUniRule annotation
Nucleotide bindingi187 – 1926NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-3595-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Swoo_3480
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292NAD kinasePRO_1000192518Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_3480.

Structurei

3D structure databases

ProteinModelPortaliB1KQZ0.
SMRiB1KQZ0. Positions 4-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227221.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KQZ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKAFQTIGL IGKPNHHGTN LTLKRLHHWL TMQGFEILVE ERVAAEMGPK
60 70 80 90 100
CNSVDLLELG DRCDLAIVVG GDGNMLGAAR VLARFDIGVI GVNRGNLGFL
110 120 130 140 150
TDLPPDSFEA ALGDVLEGKF ETEFRFLLET EVHRHGNMKS SNTAVNEAVL
160 170 180 190 200
HPGKVAHMIE FEVYIDNNFM YSQRADGMIV STPTGSTAYS LSAGGAILTP
210 220 230 240 250
NLEALILVPM FPHTLSSRPI VVDACSIIKL VVSPENGDNL EVSCDGHVML
260 270 280 290
PVLPGDEIII KRSHERLRLI HPKGHNYFHV LRNKLGWGSK LF
Length:292
Mass (Da):32,018
Last modified:April 29, 2008 - v1
Checksum:i6974C3CAC48E52A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA87746.1.
RefSeqiWP_012326080.1. NC_010506.1.
YP_001761841.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA87746; ACA87746; Swoo_3480.
GeneIDi6117812.
KEGGiswd:Swoo_3480.
PATRICi23609579. VBISheWoo126588_3591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA87746.1 .
RefSeqi WP_012326080.1. NC_010506.1.
YP_001761841.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KQZ0.
SMRi B1KQZ0. Positions 4-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_3480.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA87746 ; ACA87746 ; Swoo_3480 .
GeneIDi 6117812.
KEGGi swd:Swoo_3480.
PATRICi 23609579. VBISheWoo126588_3591.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227221.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci SWOO392500:GI2C-3595-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiNADK_SHEWM
AccessioniPrimary (citable) accession number: B1KQZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3