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B1KKY8 (GLPK_SHEWM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase

EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Swoo_4544
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP]
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity. HAMAP-Rule MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP-Rule MF_00186

Enzyme regulation

Inhibited by fructose 1,6-bisphosphate (FBP) By similarity. HAMAP-Rule MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP-Rule MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Glycerol kinase HAMAP-Rule MF_00186
PRO_1000098762

Regions

Nucleotide binding13 – 153ATP By similarity
Nucleotide binding410 – 4145ATP By similarity
Region83 – 842Substrate binding By similarity
Region244 – 2452Substrate binding By similarity

Sites

Binding site131Substrate By similarity
Binding site171ATP By similarity
Binding site1351Substrate By similarity
Binding site2661ATP By similarity
Binding site3091ATP; via carbonyl oxygen By similarity
Binding site3131ATP; via amide nitrogen By similarity
Binding site3281ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KKY8 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: D44BAFEED2822485

FASTA49554,095
        10         20         30         40         50         60 
MTKKYVVALD QGTTSSRAII FDHDANIVSV SQREFTQIYP QAGWVEHDPM EIWASQSSTL 

        70         80         90        100        110        120 
IEVIARSGIH ASEIASIGIT NQRETTVIWD KQTGKPVYNA IVWQCRRSSE ICEELKSQGL 

       130        140        150        160        170        180 
EAYIRDTTGL LLDPYFSGTK IKWILDNVSG VRERAERGEL LFGTIDTWLV WKLTEGKVHV 

       190        200        210        220        230        240 
TDPTNASRTL LFNIHTQSWD KRILEALTIP ESLLPQVKPS SAVYGKTRIA GEGGEISIAG 

       250        260        270        280        290        300 
IAGDQQSALF GQLCTEPGMA KNTYGTGCFL LMNTGEKAVK SNHGLLTTIA IGAKGEVNYA 

       310        320        330        340        350        360 
LEGSVFMGGA TIQWLRDELG LIRDAQDTEY FASRVESTNG VYLVPAFVGL GAPYWDPSAR 

       370        380        390        400        410        420 
GALVGLTRGS NRNHIIRAAL EAIAYQSRDL LDAMAKDSGV ELKKLKVDGG AVANDFLMQF 

       430        440        450        460        470        480 
QADITSVEVQ RPAVTETTAM GAAFLAGLAV GFWDSTSELK HRADIDKSFM PSISEEQKDE 

       490 
LYAGWQKAVS QTING 

« Hide

References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000961 Genomic DNA. Translation: ACA88794.1.
RefSeqYP_001762889.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KKY8.
SMRB1KKY8. Positions 3-493.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392500.Swoo_4544.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA88794; ACA88794; Swoo_4544.
GeneID6118910.
KEGGswd:Swoo_4544.
PATRIC23611813. VBISheWoo126588_4676.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHOG000222134.
KOK00864.
OMAVVWNRKT.
OrthoDBEOG6RZB46.

Enzyme and pathway databases

BioCycSWOO392500:GI2C-4694-MONOMER.
UniPathwayUPA00618; UER00672.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
InterProIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_SHEWM
AccessionPrimary (citable) accession number: B1KKY8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways