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B1KKY8

- GLPK_SHEWM

UniProt

B1KKY8 - GLPK_SHEWM

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Protein

Glycerol kinase

Gene
glpK, Swoo_4544
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP) By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131Substrate By similarity
Binding sitei17 – 171ATP By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei266 – 2661ATP By similarity
Binding sitei309 – 3091ATP; via carbonyl oxygen By similarity
Binding sitei313 – 3131ATP; via amide nitrogen By similarity
Binding sitei328 – 3281ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 153ATP By similarity
Nucleotide bindingi410 – 4145ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4694-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name:
GK
Gene namesi
Name:glpK
Ordered Locus Names:Swoo_4544
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Glycerol kinaseUniRule annotationPRO_1000098762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_4544.

Structurei

3D structure databases

ProteinModelPortaliB1KKY8.
SMRiB1KKY8. Positions 3-493.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 842Substrate binding By similarity
Regioni244 – 2452Substrate binding By similarity

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiVVWNRKT.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KKY8-1 [UniParc]FASTAAdd to Basket

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MTKKYVVALD QGTTSSRAII FDHDANIVSV SQREFTQIYP QAGWVEHDPM    50
EIWASQSSTL IEVIARSGIH ASEIASIGIT NQRETTVIWD KQTGKPVYNA 100
IVWQCRRSSE ICEELKSQGL EAYIRDTTGL LLDPYFSGTK IKWILDNVSG 150
VRERAERGEL LFGTIDTWLV WKLTEGKVHV TDPTNASRTL LFNIHTQSWD 200
KRILEALTIP ESLLPQVKPS SAVYGKTRIA GEGGEISIAG IAGDQQSALF 250
GQLCTEPGMA KNTYGTGCFL LMNTGEKAVK SNHGLLTTIA IGAKGEVNYA 300
LEGSVFMGGA TIQWLRDELG LIRDAQDTEY FASRVESTNG VYLVPAFVGL 350
GAPYWDPSAR GALVGLTRGS NRNHIIRAAL EAIAYQSRDL LDAMAKDSGV 400
ELKKLKVDGG AVANDFLMQF QADITSVEVQ RPAVTETTAM GAAFLAGLAV 450
GFWDSTSELK HRADIDKSFM PSISEEQKDE LYAGWQKAVS QTING 495
Length:495
Mass (Da):54,095
Last modified:April 29, 2008 - v1
Checksum:iD44BAFEED2822485
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88794.1.
RefSeqiWP_012327120.1. NC_010506.1.
YP_001762889.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA88794; ACA88794; Swoo_4544.
GeneIDi6118910.
KEGGiswd:Swoo_4544.
PATRICi23611813. VBISheWoo126588_4676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88794.1 .
RefSeqi WP_012327120.1. NC_010506.1.
YP_001762889.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KKY8.
SMRi B1KKY8. Positions 3-493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_4544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA88794 ; ACA88794 ; Swoo_4544 .
GeneIDi 6118910.
KEGGi swd:Swoo_4544.
PATRICi 23611813. VBISheWoo126588_4676.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi VVWNRKT.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci SWOO392500:GI2C-4694-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiGLPK_SHEWM
AccessioniPrimary (citable) accession number: B1KKY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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