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B1KKY8

- GLPK_SHEWM

UniProt

B1KKY8 - GLPK_SHEWM

Protein

Glycerol kinase

Gene

glpK

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

    Enzyme regulationi

    Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131SubstrateUniRule annotation
    Binding sitei17 – 171ATPUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei266 – 2661ATPUniRule annotation
    Binding sitei309 – 3091ATP; via carbonyl oxygenUniRule annotation
    Binding sitei313 – 3131ATP; via amide nitrogenUniRule annotation
    Binding sitei328 – 3281ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 153ATPUniRule annotation
    Nucleotide bindingi410 – 4145ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glycerol kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWOO392500:GI2C-4694-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
    Alternative name(s):
    ATP:glycerol 3-phosphotransferaseUniRule annotation
    GlycerokinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:glpKUniRule annotation
    Ordered Locus Names:Swoo_4544
    OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
    Taxonomic identifieri392500 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 495495Glycerol kinasePRO_1000098762Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392500.Swoo_4544.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KKY8.
    SMRiB1KKY8. Positions 3-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni83 – 842Substrate bindingUniRule annotation
    Regioni244 – 2452Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the FGGY kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0554.
    HOGENOMiHOG000222134.
    KOiK00864.
    OMAiVVWNRKT.
    OrthoDBiEOG6RZB46.

    Family and domain databases

    HAMAPiMF_00186. Glycerol_kin.
    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1KKY8-1 [UniParc]FASTAAdd to Basket

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    MTKKYVVALD QGTTSSRAII FDHDANIVSV SQREFTQIYP QAGWVEHDPM    50
    EIWASQSSTL IEVIARSGIH ASEIASIGIT NQRETTVIWD KQTGKPVYNA 100
    IVWQCRRSSE ICEELKSQGL EAYIRDTTGL LLDPYFSGTK IKWILDNVSG 150
    VRERAERGEL LFGTIDTWLV WKLTEGKVHV TDPTNASRTL LFNIHTQSWD 200
    KRILEALTIP ESLLPQVKPS SAVYGKTRIA GEGGEISIAG IAGDQQSALF 250
    GQLCTEPGMA KNTYGTGCFL LMNTGEKAVK SNHGLLTTIA IGAKGEVNYA 300
    LEGSVFMGGA TIQWLRDELG LIRDAQDTEY FASRVESTNG VYLVPAFVGL 350
    GAPYWDPSAR GALVGLTRGS NRNHIIRAAL EAIAYQSRDL LDAMAKDSGV 400
    ELKKLKVDGG AVANDFLMQF QADITSVEVQ RPAVTETTAM GAAFLAGLAV 450
    GFWDSTSELK HRADIDKSFM PSISEEQKDE LYAGWQKAVS QTING 495
    Length:495
    Mass (Da):54,095
    Last modified:April 29, 2008 - v1
    Checksum:iD44BAFEED2822485
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA88794.1.
    RefSeqiWP_012327120.1. NC_010506.1.
    YP_001762889.1. NC_010506.1.

    Genome annotation databases

    EnsemblBacteriaiACA88794; ACA88794; Swoo_4544.
    GeneIDi6118910.
    KEGGiswd:Swoo_4544.
    PATRICi23611813. VBISheWoo126588_4676.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA88794.1 .
    RefSeqi WP_012327120.1. NC_010506.1.
    YP_001762889.1. NC_010506.1.

    3D structure databases

    ProteinModelPortali B1KKY8.
    SMRi B1KKY8. Positions 3-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392500.Swoo_4544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA88794 ; ACA88794 ; Swoo_4544 .
    GeneIDi 6118910.
    KEGGi swd:Swoo_4544.
    PATRICi 23611813. VBISheWoo126588_4676.

    Phylogenomic databases

    eggNOGi COG0554.
    HOGENOMi HOG000222134.
    KOi K00864.
    OMAi VVWNRKT.
    OrthoDBi EOG6RZB46.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci SWOO392500:GI2C-4694-MONOMER.

    Family and domain databases

    HAMAPi MF_00186. Glycerol_kin.
    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51908 / MS32.

    Entry informationi

    Entry nameiGLPK_SHEWM
    AccessioniPrimary (citable) accession number: B1KKY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3