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B1KKY8

- GLPK_SHEWM

UniProt

B1KKY8 - GLPK_SHEWM

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Protein

Glycerol kinase

Gene

glpK

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei13 – 131SubstrateUniRule annotation
Binding sitei17 – 171ATPUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Binding sitei266 – 2661ATPUniRule annotation
Binding sitei309 – 3091ATP; via carbonyl oxygenUniRule annotation
Binding sitei313 – 3131ATP; via amide nitrogenUniRule annotation
Binding sitei328 – 3281ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 153ATPUniRule annotation
Nucleotide bindingi410 – 4145ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4694-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Swoo_4544
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Glycerol kinasePRO_1000098762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_4544.

Structurei

3D structure databases

ProteinModelPortaliB1KKY8.
SMRiB1KKY8. Positions 3-493.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 842Substrate bindingUniRule annotation
Regioni244 – 2452Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiVVWNRKT.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KKY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKKYVVALD QGTTSSRAII FDHDANIVSV SQREFTQIYP QAGWVEHDPM
60 70 80 90 100
EIWASQSSTL IEVIARSGIH ASEIASIGIT NQRETTVIWD KQTGKPVYNA
110 120 130 140 150
IVWQCRRSSE ICEELKSQGL EAYIRDTTGL LLDPYFSGTK IKWILDNVSG
160 170 180 190 200
VRERAERGEL LFGTIDTWLV WKLTEGKVHV TDPTNASRTL LFNIHTQSWD
210 220 230 240 250
KRILEALTIP ESLLPQVKPS SAVYGKTRIA GEGGEISIAG IAGDQQSALF
260 270 280 290 300
GQLCTEPGMA KNTYGTGCFL LMNTGEKAVK SNHGLLTTIA IGAKGEVNYA
310 320 330 340 350
LEGSVFMGGA TIQWLRDELG LIRDAQDTEY FASRVESTNG VYLVPAFVGL
360 370 380 390 400
GAPYWDPSAR GALVGLTRGS NRNHIIRAAL EAIAYQSRDL LDAMAKDSGV
410 420 430 440 450
ELKKLKVDGG AVANDFLMQF QADITSVEVQ RPAVTETTAM GAAFLAGLAV
460 470 480 490
GFWDSTSELK HRADIDKSFM PSISEEQKDE LYAGWQKAVS QTING
Length:495
Mass (Da):54,095
Last modified:April 29, 2008 - v1
Checksum:iD44BAFEED2822485
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88794.1.
RefSeqiWP_012327120.1. NC_010506.1.
YP_001762889.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA88794; ACA88794; Swoo_4544.
GeneIDi6118910.
KEGGiswd:Swoo_4544.
PATRICi23611813. VBISheWoo126588_4676.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88794.1 .
RefSeqi WP_012327120.1. NC_010506.1.
YP_001762889.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KKY8.
SMRi B1KKY8. Positions 3-493.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_4544.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA88794 ; ACA88794 ; Swoo_4544 .
GeneIDi 6118910.
KEGGi swd:Swoo_4544.
PATRICi 23611813. VBISheWoo126588_4676.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi VVWNRKT.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci SWOO392500:GI2C-4694-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiGLPK_SHEWM
AccessioniPrimary (citable) accession number: B1KKY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3