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B1KJM7

- 3HAO_SHEWM

UniProt

B1KJM7 - 3HAO_SHEWM

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene
nbaC, Swoo_1408
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461Dioxygen By similarity
Metal bindingi50 – 501Iron 1; catalytic By similarity
Metal bindingi56 – 561Iron 1; catalytic By similarity
Binding sitei56 – 561Substrate By similarity
Metal bindingi94 – 941Iron 1; catalytic By similarity
Binding sitei98 – 981Substrate By similarity
Binding sitei109 – 1091Substrate By similarity
Metal bindingi124 – 1241Iron 2 By similarity
Metal bindingi127 – 1271Iron 2 By similarity
Metal bindingi161 – 1611Iron 2 By similarity
Metal bindingi164 – 1641Iron 2 By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-1431-MONOMER.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
Name:nbaC
Ordered Locus Names:Swoo_1408
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1891893-hydroxyanthranilate 3,4-dioxygenaseUniRule annotationPRO_1000134550Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi392500.Swoo_1408.

Structurei

3D structure databases

ProteinModelPortaliB1KJM7.
SMRiB1KJM7. Positions 5-171.

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OrthoDBiEOG6PW234.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KJM7-1 [UniParc]FASTAAdd to Basket

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MSKLAAFNFQ QWIDEHQHLL KPPVGNVQIW ENTDMMVTVV GGPNQRTDFH    50
DDPVEEFFYQ LKGDMVLKII EEGKCHDLFI REGDIFFLPP HVRHSPQRPM 100
PGSIGLVIEP KRPEGAKDAF EWYCFKCDGL VHRVEVLLKS IVRDLPPIYQ 150
AFYQDEQART CPQCGELHPG KEPPQGWVTL LENKEQDKS 189
Length:189
Mass (Da):21,866
Last modified:April 29, 2008 - v1
Checksum:i7F58E64EF3265606
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA85700.1.
RefSeqiWP_012324046.1. NC_010506.1.
YP_001759795.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA85700; ACA85700; Swoo_1408.
GeneIDi6115648.
KEGGiswd:Swoo_1408.
PATRICi23605151. VBISheWoo126588_1466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA85700.1 .
RefSeqi WP_012324046.1. NC_010506.1.
YP_001759795.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KJM7.
SMRi B1KJM7. Positions 5-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_1408.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA85700 ; ACA85700 ; Swoo_1408 .
GeneIDi 6115648.
KEGGi swd:Swoo_1408.
PATRICi 23605151. VBISheWoo126588_1466.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OrthoDBi EOG6PW234.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .
BioCyci SWOO392500:GI2C-1431-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry namei3HAO_SHEWM
AccessioniPrimary (citable) accession number: B1KJM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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