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B1KJM7

- 3HAO_SHEWM

UniProt

B1KJM7 - 3HAO_SHEWM

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

nbaC

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Binds 2 Fe2+ ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461DioxygenUniRule annotation
Metal bindingi50 – 501Iron 1; catalyticUniRule annotation
Metal bindingi56 – 561Iron 1; catalyticUniRule annotation
Binding sitei56 – 561SubstrateUniRule annotation
Metal bindingi94 – 941Iron 1; catalyticUniRule annotation
Binding sitei98 – 981SubstrateUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Metal bindingi124 – 1241Iron 2UniRule annotation
Metal bindingi127 – 1271Iron 2UniRule annotation
Metal bindingi161 – 1611Iron 2UniRule annotation
Metal bindingi164 – 1641Iron 2UniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-1431-MONOMER.
UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:nbaCUniRule annotation
Ordered Locus Names:Swoo_1408
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1891893-hydroxyanthranilate 3,4-dioxygenasePRO_1000134550Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi392500.Swoo_1408.

Structurei

3D structure databases

ProteinModelPortaliB1KJM7.
SMRiB1KJM7. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OrthoDBiEOG6PW234.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KJM7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKLAAFNFQ QWIDEHQHLL KPPVGNVQIW ENTDMMVTVV GGPNQRTDFH
60 70 80 90 100
DDPVEEFFYQ LKGDMVLKII EEGKCHDLFI REGDIFFLPP HVRHSPQRPM
110 120 130 140 150
PGSIGLVIEP KRPEGAKDAF EWYCFKCDGL VHRVEVLLKS IVRDLPPIYQ
160 170 180
AFYQDEQART CPQCGELHPG KEPPQGWVTL LENKEQDKS
Length:189
Mass (Da):21,866
Last modified:April 29, 2008 - v1
Checksum:i7F58E64EF3265606
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA85700.1.
RefSeqiWP_012324046.1. NC_010506.1.
YP_001759795.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA85700; ACA85700; Swoo_1408.
GeneIDi6115648.
KEGGiswd:Swoo_1408.
PATRICi23605151. VBISheWoo126588_1466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA85700.1 .
RefSeqi WP_012324046.1. NC_010506.1.
YP_001759795.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KJM7.
SMRi B1KJM7. Positions 5-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_1408.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA85700 ; ACA85700 ; Swoo_1408 .
GeneIDi 6115648.
KEGGi swd:Swoo_1408.
PATRICi 23605151. VBISheWoo126588_1466.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OrthoDBi EOG6PW234.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .
BioCyci SWOO392500:GI2C-1431-MONOMER.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry namei3HAO_SHEWM
AccessioniPrimary (citable) accession number: B1KJM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3