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B1KJM7 (3HAO_SHEWM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Name:nbaC
Ordered Locus Names:Swoo_1408
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP]
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_00825

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP-Rule MF_00825

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_00825

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00825

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1891893-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_00825
PRO_1000134550

Sites

Metal binding501Iron 1; catalytic By similarity
Metal binding561Iron 1; catalytic By similarity
Metal binding941Iron 1; catalytic By similarity
Metal binding1241Iron 2 By similarity
Metal binding1271Iron 2 By similarity
Metal binding1611Iron 2 By similarity
Metal binding1641Iron 2 By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site981Substrate By similarity
Binding site1091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KJM7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 7F58E64EF3265606

FASTA18921,866
        10         20         30         40         50         60 
MSKLAAFNFQ QWIDEHQHLL KPPVGNVQIW ENTDMMVTVV GGPNQRTDFH DDPVEEFFYQ 

        70         80         90        100        110        120 
LKGDMVLKII EEGKCHDLFI REGDIFFLPP HVRHSPQRPM PGSIGLVIEP KRPEGAKDAF 

       130        140        150        160        170        180 
EWYCFKCDGL VHRVEVLLKS IVRDLPPIYQ AFYQDEQART CPQCGELHPG KEPPQGWVTL 


LENKEQDKS 

« Hide

References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000961 Genomic DNA. Translation: ACA85700.1.
RefSeqYP_001759795.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KJM7.
SMRB1KJM7. Positions 5-171.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392500.Swoo_1408.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA85700; ACA85700; Swoo_1408.
GeneID6115648.
KEGGswd:Swoo_1408.
PATRIC23605151. VBISheWoo126588_1466.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHOG000218448.
KOK00452.
OMAHINQTPE.
OrthoDBEOG6PW234.
ProtClustDBPRK13264.

Enzyme and pathway databases

BioCycSWOO392500:GI2C-1431-MONOMER.
UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_SHEWM
AccessionPrimary (citable) accession number: B1KJM7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways