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B1KJM7 (3HAO_SHEWM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Ordered Locus Names:Swoo_1408
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP]
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP MF_00825

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP MF_00825

Subunit structure

Homodimer By similarity. HAMAP MF_00825

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1891893-hydroxyanthranilate 3,4-dioxygenase HAMAP MF_00825
PRO_1000134550

Sites

Metal binding501Iron 1; catalytic By similarity
Metal binding561Iron 1; catalytic By similarity
Metal binding941Iron 1; catalytic By similarity
Metal binding1241Iron 2 By similarity
Metal binding1271Iron 2 By similarity
Metal binding1611Iron 2 By similarity
Metal binding1641Iron 2 By similarity
Binding site461Dioxygen By similarity
Binding site561Substrate By similarity
Binding site981Substrate By similarity
Binding site1091Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KJM7 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 7F58E64EF3265606

FASTA18921,866
        10         20         30         40         50         60 
MSKLAAFNFQ QWIDEHQHLL KPPVGNVQIW ENTDMMVTVV GGPNQRTDFH DDPVEEFFYQ 

        70         80         90        100        110        120 
LKGDMVLKII EEGKCHDLFI REGDIFFLPP HVRHSPQRPM PGSIGLVIEP KRPEGAKDAF 

       130        140        150        160        170        180 
EWYCFKCDGL VHRVEVLLKS IVRDLPPIYQ AFYQDEQART CPQCGELHPG KEPPQGWVTL 


LENKEQDKS

« Hide

References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000961 Genomic DNA. Translation: ACA85700.1.
RefSeqYP_001759795.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KJM7.
SMRB1KJM7. Positions 5-171.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1KJM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6115648.
GenomeReviewsGene locus Swoo_1408 in contig CP000961_GR.
KEGGswd:Swoo_1408.
PATRIC23605151. VBISheWoo126588_1466.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG341987.
OMALKPPVNN.
ProtClustDBPRK13264.

Family and domain databases

HAMAPMF_00825. 3_HAO.
[Tree]
InterProIPR010329. 3hydroanth_dOase.
IPR011051. Cupin_RmlC_type.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
Gene3DG3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
KOK00452.
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR03037. Anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_SHEWM
AccessionPrimary (citable) accession number: B1KJM7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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