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B1KJL0

- ACDH_SHEWM

UniProt

B1KJL0 - ACDH_SHEWM

Protein

Acetaldehyde dehydrogenase

Gene

Swoo_1391

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei143 – 1431Acyl-thioester intermediateUniRule annotation
    Binding sitei285 – 2851NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 164NADUniRule annotation
    Nucleotide bindingi174 – 1829NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSWOO392500:GI2C-1414-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:Swoo_1391
    OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
    Taxonomic identifieri392500 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Acetaldehyde dehydrogenasePRO_0000387741Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392500.Swoo_1391.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KJL0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1KJL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNKKINIAL IGSGNIGTDL MIKALRSSTL NPVWMVGIDE NSDGLKRAKA    50
    LGLKTTHLGI DELLTHIEAD NIQIAFDATS AYVHEENNRK LQSKGVKVID 100
    LTPAAIGPYC IPPVNLESLL SQTENQTQIN DGSISGNLNM VTCGGQATIP 150
    IIAAISRVQS VDYGEIVATI ASKSAGPGTR KNIDEFTRTT ADAIEQIGGA 200
    RQGKAIIVMN PAEPPLMMRD TVHCLTQDEP DVEAITASVL SMIEQVQEYV 250
    PGYRLKNGPV FDGNRVSVFL EVAGLGDYLP EYAGNLDIMT SAALCTGEML 300
    ARNLRSNMSV KDSHH 315
    Length:315
    Mass (Da):33,801
    Last modified:November 3, 2009 - v2
    Checksum:iB05896ECA2B64FE3
    GO

    Sequence cautioni

    The sequence ACA85683.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA85683.1. Different initiation.
    RefSeqiYP_001759778.1. NC_010506.1.

    Genome annotation databases

    EnsemblBacteriaiACA85683; ACA85683; Swoo_1391.
    GeneIDi6115631.
    KEGGiswd:Swoo_1391.
    PATRICi23605109. VBISheWoo126588_1445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA85683.1 . Different initiation.
    RefSeqi YP_001759778.1. NC_010506.1.

    3D structure databases

    ProteinModelPortali B1KJL0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392500.Swoo_1391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA85683 ; ACA85683 ; Swoo_1391 .
    GeneIDi 6115631.
    KEGGi swd:Swoo_1391.
    PATRICi 23605109. VBISheWoo126588_1445.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci SWOO392500:GI2C-1414-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51908 / MS32.

    Entry informationi

    Entry nameiACDH_SHEWM
    AccessioniPrimary (citable) accession number: B1KJL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3