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B1KJL0

- ACDH_SHEWM

UniProt

B1KJL0 - ACDH_SHEWM

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Protein

Acetaldehyde dehydrogenase

Gene

Swoo_1391

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei143 – 1431Acyl-thioester intermediateUniRule annotation
Binding sitei285 – 2851NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADUniRule annotation
Nucleotide bindingi174 – 1829NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-1414-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Swoo_1391
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Acetaldehyde dehydrogenasePRO_0000387741Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_1391.

Structurei

3D structure databases

ProteinModelPortaliB1KJL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK18366.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KJL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNKKINIAL IGSGNIGTDL MIKALRSSTL NPVWMVGIDE NSDGLKRAKA
60 70 80 90 100
LGLKTTHLGI DELLTHIEAD NIQIAFDATS AYVHEENNRK LQSKGVKVID
110 120 130 140 150
LTPAAIGPYC IPPVNLESLL SQTENQTQIN DGSISGNLNM VTCGGQATIP
160 170 180 190 200
IIAAISRVQS VDYGEIVATI ASKSAGPGTR KNIDEFTRTT ADAIEQIGGA
210 220 230 240 250
RQGKAIIVMN PAEPPLMMRD TVHCLTQDEP DVEAITASVL SMIEQVQEYV
260 270 280 290 300
PGYRLKNGPV FDGNRVSVFL EVAGLGDYLP EYAGNLDIMT SAALCTGEML
310
ARNLRSNMSV KDSHH
Length:315
Mass (Da):33,801
Last modified:November 3, 2009 - v2
Checksum:iB05896ECA2B64FE3
GO

Sequence cautioni

The sequence ACA85683.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA85683.1. Different initiation.
RefSeqiYP_001759778.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA85683; ACA85683; Swoo_1391.
GeneIDi6115631.
KEGGiswd:Swoo_1391.
PATRICi23605109. VBISheWoo126588_1445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA85683.1 . Different initiation.
RefSeqi YP_001759778.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KJL0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_1391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA85683 ; ACA85683 ; Swoo_1391 .
GeneIDi 6115631.
KEGGi swd:Swoo_1391.
PATRICi 23605109. VBISheWoo126588_1445.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K18366.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci SWOO392500:GI2C-1414-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiACDH_SHEWM
AccessioniPrimary (citable) accession number: B1KJL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: October 29, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3