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B1KJC0

- FTHS_SHEWM

UniProt

B1KJC0 - FTHS_SHEWM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSWOO392500:GI2C-4478-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Swoo_4339
    OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
    Taxonomic identifieri392500 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000196824Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi392500.Swoo_4339.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KJC0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiAMTVIMS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1KJC0-1 [UniParc]FASTAAdd to Basket

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    MLTDIEISRQ ATPQPISDIA KKFGIKKDEL SQFGDAKAKV KISILDRVKD    50
    NVEGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLNAIGRKTC ACIRQPSMGP 100
    VFGIKGGAAG GGYSQVIPME EMNLHLTGDI HAVSSAHNLA AAAVDARLFH 150
    ESRLSADEYT LQSGSAPLNI DPEQILWRRV VDHNERSLRN ITVGLGDING 200
    PVHASGFDIT AASELMAILA LSHDLKDMRK RIGRLVLALD KHAQPITAEM 250
    IGVAGAMTVI MSNAIEPTLM QTLTGDPCLI HAGPFANIAH GNSSIIADRI 300
    ALKFADFVVT EGGFGSDMGF EKFCNIKVRE SGKAPDAAVL VVTLKALKAN 350
    SGLESKQDIN LPDQARLEAG FLNLKWHMDN VSQYGVPVVV ALNRFPSDTQ 400
    EELEWLKREV MLAGAFGCEI SDAFSLGANG AEALAHKVVE ATEQDSDFRL 450
    LYSSDASIEA KLLTIAESGY GARGVVLSDE AKAQLEQIKA MGLDNLAVCI 500
    AKTPLSISHD PLLKGVPQGF ELPIAQLKIN AGAGFITALV GKVMTMPGLG 550
    VKPGYLNIDI NEQDEIVGLA 570
    Length:570
    Mass (Da):60,642
    Last modified:April 29, 2008 - v1
    Checksum:i8596D91447E9335C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA88592.1.
    RefSeqiYP_001762687.1. NC_010506.1.

    Genome annotation databases

    EnsemblBacteriaiACA88592; ACA88592; Swoo_4339.
    GeneIDi6118694.
    KEGGiswd:Swoo_4339.
    PATRICi23611361. VBISheWoo126588_4461.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA88592.1 .
    RefSeqi YP_001762687.1. NC_010506.1.

    3D structure databases

    ProteinModelPortali B1KJC0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392500.Swoo_4339.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA88592 ; ACA88592 ; Swoo_4339 .
    GeneIDi 6118694.
    KEGGi swd:Swoo_4339.
    PATRICi 23611361. VBISheWoo126588_4461.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi AMTVIMS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SWOO392500:GI2C-4478-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51908 / MS32.

    Entry informationi

    Entry nameiFTHS_SHEWM
    AccessioniPrimary (citable) accession number: B1KJC0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3