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B1KJC0

- FTHS_SHEWM

UniProt

B1KJC0 - FTHS_SHEWM

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4478-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Swoo_4339
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000196824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_4339.

Structurei

3D structure databases

ProteinModelPortaliB1KJC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiAMTVIMS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KJC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTDIEISRQ ATPQPISDIA KKFGIKKDEL SQFGDAKAKV KISILDRVKD
60 70 80 90 100
NVEGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLNAIGRKTC ACIRQPSMGP
110 120 130 140 150
VFGIKGGAAG GGYSQVIPME EMNLHLTGDI HAVSSAHNLA AAAVDARLFH
160 170 180 190 200
ESRLSADEYT LQSGSAPLNI DPEQILWRRV VDHNERSLRN ITVGLGDING
210 220 230 240 250
PVHASGFDIT AASELMAILA LSHDLKDMRK RIGRLVLALD KHAQPITAEM
260 270 280 290 300
IGVAGAMTVI MSNAIEPTLM QTLTGDPCLI HAGPFANIAH GNSSIIADRI
310 320 330 340 350
ALKFADFVVT EGGFGSDMGF EKFCNIKVRE SGKAPDAAVL VVTLKALKAN
360 370 380 390 400
SGLESKQDIN LPDQARLEAG FLNLKWHMDN VSQYGVPVVV ALNRFPSDTQ
410 420 430 440 450
EELEWLKREV MLAGAFGCEI SDAFSLGANG AEALAHKVVE ATEQDSDFRL
460 470 480 490 500
LYSSDASIEA KLLTIAESGY GARGVVLSDE AKAQLEQIKA MGLDNLAVCI
510 520 530 540 550
AKTPLSISHD PLLKGVPQGF ELPIAQLKIN AGAGFITALV GKVMTMPGLG
560 570
VKPGYLNIDI NEQDEIVGLA
Length:570
Mass (Da):60,642
Last modified:April 29, 2008 - v1
Checksum:i8596D91447E9335C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88592.1.
RefSeqiWP_012326918.1. NC_010506.1.
YP_001762687.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA88592; ACA88592; Swoo_4339.
GeneIDi6118694.
KEGGiswd:Swoo_4339.
PATRICi23611361. VBISheWoo126588_4461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88592.1 .
RefSeqi WP_012326918.1. NC_010506.1.
YP_001762687.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KJC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_4339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA88592 ; ACA88592 ; Swoo_4339 .
GeneIDi 6118694.
KEGGi swd:Swoo_4339.
PATRICi 23611361. VBISheWoo126588_4461.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi AMTVIMS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SWOO392500:GI2C-4478-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiFTHS_SHEWM
AccessioniPrimary (citable) accession number: B1KJC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3