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B1KJC0

- FTHS_SHEWM

UniProt

B1KJC0 - FTHS_SHEWM

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Swoo_4339
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4478-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Swoo_4339
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000196824Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_4339.

Structurei

3D structure databases

ProteinModelPortaliB1KJC0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiAMTVIMS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KJC0-1 [UniParc]FASTAAdd to Basket

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MLTDIEISRQ ATPQPISDIA KKFGIKKDEL SQFGDAKAKV KISILDRVKD    50
NVEGKLVIVT AVTPTPFGEG KTVTSIGLTQ GLNAIGRKTC ACIRQPSMGP 100
VFGIKGGAAG GGYSQVIPME EMNLHLTGDI HAVSSAHNLA AAAVDARLFH 150
ESRLSADEYT LQSGSAPLNI DPEQILWRRV VDHNERSLRN ITVGLGDING 200
PVHASGFDIT AASELMAILA LSHDLKDMRK RIGRLVLALD KHAQPITAEM 250
IGVAGAMTVI MSNAIEPTLM QTLTGDPCLI HAGPFANIAH GNSSIIADRI 300
ALKFADFVVT EGGFGSDMGF EKFCNIKVRE SGKAPDAAVL VVTLKALKAN 350
SGLESKQDIN LPDQARLEAG FLNLKWHMDN VSQYGVPVVV ALNRFPSDTQ 400
EELEWLKREV MLAGAFGCEI SDAFSLGANG AEALAHKVVE ATEQDSDFRL 450
LYSSDASIEA KLLTIAESGY GARGVVLSDE AKAQLEQIKA MGLDNLAVCI 500
AKTPLSISHD PLLKGVPQGF ELPIAQLKIN AGAGFITALV GKVMTMPGLG 550
VKPGYLNIDI NEQDEIVGLA 570
Length:570
Mass (Da):60,642
Last modified:April 29, 2008 - v1
Checksum:i8596D91447E9335C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88592.1.
RefSeqiYP_001762687.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA88592; ACA88592; Swoo_4339.
GeneIDi6118694.
KEGGiswd:Swoo_4339.
PATRICi23611361. VBISheWoo126588_4461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88592.1 .
RefSeqi YP_001762687.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KJC0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_4339.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA88592 ; ACA88592 ; Swoo_4339 .
GeneIDi 6118694.
KEGGi swd:Swoo_4339.
PATRICi 23611361. VBISheWoo126588_4461.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi AMTVIMS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SWOO392500:GI2C-4478-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiFTHS_SHEWM
AccessioniPrimary (citable) accession number: B1KJC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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