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B1KJC0 (FTHS_SHEWM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Swoo_4339
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP]
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000196824

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KJC0 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 8596D91447E9335C

FASTA57060,642
        10         20         30         40         50         60 
MLTDIEISRQ ATPQPISDIA KKFGIKKDEL SQFGDAKAKV KISILDRVKD NVEGKLVIVT 

        70         80         90        100        110        120 
AVTPTPFGEG KTVTSIGLTQ GLNAIGRKTC ACIRQPSMGP VFGIKGGAAG GGYSQVIPME 

       130        140        150        160        170        180 
EMNLHLTGDI HAVSSAHNLA AAAVDARLFH ESRLSADEYT LQSGSAPLNI DPEQILWRRV 

       190        200        210        220        230        240 
VDHNERSLRN ITVGLGDING PVHASGFDIT AASELMAILA LSHDLKDMRK RIGRLVLALD 

       250        260        270        280        290        300 
KHAQPITAEM IGVAGAMTVI MSNAIEPTLM QTLTGDPCLI HAGPFANIAH GNSSIIADRI 

       310        320        330        340        350        360 
ALKFADFVVT EGGFGSDMGF EKFCNIKVRE SGKAPDAAVL VVTLKALKAN SGLESKQDIN 

       370        380        390        400        410        420 
LPDQARLEAG FLNLKWHMDN VSQYGVPVVV ALNRFPSDTQ EELEWLKREV MLAGAFGCEI 

       430        440        450        460        470        480 
SDAFSLGANG AEALAHKVVE ATEQDSDFRL LYSSDASIEA KLLTIAESGY GARGVVLSDE 

       490        500        510        520        530        540 
AKAQLEQIKA MGLDNLAVCI AKTPLSISHD PLLKGVPQGF ELPIAQLKIN AGAGFITALV 

       550        560        570 
GKVMTMPGLG VKPGYLNIDI NEQDEIVGLA 

« Hide

References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000961 Genomic DNA. Translation: ACA88592.1.
RefSeqYP_001762687.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KJC0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392500.Swoo_4339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA88592; ACA88592; Swoo_4339.
GeneID6118694.
KEGGswd:Swoo_4339.
PATRIC23611361. VBISheWoo126588_4461.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAAMTVIMS.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycSWOO392500:GI2C-4478-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SHEWM
AccessionPrimary (citable) accession number: B1KJC0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways