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B1KG87

- GCSP_SHEWM

UniProt

B1KG87 - GCSP_SHEWM

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Swoo_3967
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Swoo_3967
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000132456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei716 – 7161N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi392500.Swoo_3967.

Structurei

3D structure databases

ProteinModelPortaliB1KG87.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KG87-1 [UniParc]FASTAAdd to Basket

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MTTETLTTLE QHDRFLGRHI GPDSEQRQEM LNYVGAESLE DLTTQIVPES    50
IRLNRDLAVG DNVSEAEGLA YIRQIADKNK VFKSYIGMGY YGTEVPSVIQ 100
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQLSMDLTG LDLASSSLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVIKT RAECFGMEVV 200
VGPAEEAVNY ELFGALFQYT NRYGQITDFT ELFTALHEKK AIISVAADIM 250
SLVMLKSPGS MGADVVFGNS QRFGVPMGFG GPHAAFFVSR DAHKRSLPGR 300
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
FHGPQGLKVI AERIHRLTDI LAAGLTAKGV ELVNNTWFDT LSIKGLDAKA 400
VQKRADAAGI NLRVDSCSES DGSSDQVLGV SLAETTTRTD VTQLFDVILG 450
EGHGLDVAAL DAQVMADSTS VPAELVRQDA ILTHPTFNRY HSETEMMRYI 500
KRLENKDLAL NHSMISLGSC TMKLNAATEM MPITWPEFGN MHPFCPQDQA 550
QGYAQLLGEL SEWLVDITGY DAVSLQPNSG AQGEYAGLLA IKQYHESRGD 600
AHRNICLIPS SAHGTNPASA QLAGMKIVVT ACDKAGNIDM EDLKAKAAEV 650
ADNLSCIMVT YPSTHGVYEE TIGEICEVIH QHGGQVYLDG ANMNAQVGLT 700
SPGFIGADVS HLNLHKTFAI PHGGGGPGMG PIGVKKHLAP FLSGHSVVKH 750
GLESDGNGAV SAAPYGSAGI LPITWMYIKL LGKQGLREST QVALLNANYM 800
MKKLSEHYPV LYTGRNDRVA HECIIDLRPL KEASGVTEMD IAKRLNDYGF 850
HAPTMSFPVA GTLMIEPTES ESKVELDRFI EAMVSIRAEA ARVESGEWPV 900
DNNPLHNAPH TLADIMDPEF DSRPYSREVA VFPTAAVKQN KFWPTVNRID 950
DVYGDRNLFC ACVPISDYE 969
Length:969
Mass (Da):105,773
Last modified:April 29, 2008 - v1
Checksum:i77986D152BDE4B80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88224.1.
RefSeqiYP_001762319.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA88224; ACA88224; Swoo_3967.
GeneIDi6118316.
KEGGiswd:Swoo_3967.
PATRICi23610597. VBISheWoo126588_4084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA88224.1 .
RefSeqi YP_001762319.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KG87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_3967.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA88224 ; ACA88224 ; Swoo_3967 .
GeneIDi 6118316.
KEGGi swd:Swoo_3967.
PATRICi 23610597. VBISheWoo126588_4084.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SWOO392500:GI2C-4100-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiGCSP_SHEWM
AccessioniPrimary (citable) accession number: B1KG87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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