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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Swoo_3967
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 969969Glycine dehydrogenase (decarboxylating)PRO_1000132456Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei716 – 7161N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi392500.Swoo_3967.

Structurei

3D structure databases

ProteinModelPortaliB1KG87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B1KG87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTETLTTLE QHDRFLGRHI GPDSEQRQEM LNYVGAESLE DLTTQIVPES
60 70 80 90 100
IRLNRDLAVG DNVSEAEGLA YIRQIADKNK VFKSYIGMGY YGTEVPSVIQ
110 120 130 140 150
RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQLSMDLTG LDLASSSLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVIKT RAECFGMEVV
210 220 230 240 250
VGPAEEAVNY ELFGALFQYT NRYGQITDFT ELFTALHEKK AIISVAADIM
260 270 280 290 300
SLVMLKSPGS MGADVVFGNS QRFGVPMGFG GPHAAFFVSR DAHKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
FHGPQGLKVI AERIHRLTDI LAAGLTAKGV ELVNNTWFDT LSIKGLDAKA
410 420 430 440 450
VQKRADAAGI NLRVDSCSES DGSSDQVLGV SLAETTTRTD VTQLFDVILG
460 470 480 490 500
EGHGLDVAAL DAQVMADSTS VPAELVRQDA ILTHPTFNRY HSETEMMRYI
510 520 530 540 550
KRLENKDLAL NHSMISLGSC TMKLNAATEM MPITWPEFGN MHPFCPQDQA
560 570 580 590 600
QGYAQLLGEL SEWLVDITGY DAVSLQPNSG AQGEYAGLLA IKQYHESRGD
610 620 630 640 650
AHRNICLIPS SAHGTNPASA QLAGMKIVVT ACDKAGNIDM EDLKAKAAEV
660 670 680 690 700
ADNLSCIMVT YPSTHGVYEE TIGEICEVIH QHGGQVYLDG ANMNAQVGLT
710 720 730 740 750
SPGFIGADVS HLNLHKTFAI PHGGGGPGMG PIGVKKHLAP FLSGHSVVKH
760 770 780 790 800
GLESDGNGAV SAAPYGSAGI LPITWMYIKL LGKQGLREST QVALLNANYM
810 820 830 840 850
MKKLSEHYPV LYTGRNDRVA HECIIDLRPL KEASGVTEMD IAKRLNDYGF
860 870 880 890 900
HAPTMSFPVA GTLMIEPTES ESKVELDRFI EAMVSIRAEA ARVESGEWPV
910 920 930 940 950
DNNPLHNAPH TLADIMDPEF DSRPYSREVA VFPTAAVKQN KFWPTVNRID
960
DVYGDRNLFC ACVPISDYE
Length:969
Mass (Da):105,773
Last modified:April 29, 2008 - v1
Checksum:i77986D152BDE4B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA88224.1.
RefSeqiWP_012326554.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA88224; ACA88224; Swoo_3967.
KEGGiswd:Swoo_3967.
PATRICi23610597. VBISheWoo126588_4084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA88224.1.
RefSeqiWP_012326554.1. NC_010506.1.

3D structure databases

ProteinModelPortaliB1KG87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi392500.Swoo_3967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA88224; ACA88224; Swoo_3967.
KEGGiswd:Swoo_3967.
PATRICi23610597. VBISheWoo126588_4084.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-4100-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiGCSP_SHEWM
AccessioniPrimary (citable) accession number: B1KG87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 22, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.