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B1KG87 (GCSP_SHEWM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Swoo_3967
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP]
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length969 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 969969Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132456

Amino acid modifications

Modified residue7161N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B1KG87 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 77986D152BDE4B80

FASTA969105,773
        10         20         30         40         50         60 
MTTETLTTLE QHDRFLGRHI GPDSEQRQEM LNYVGAESLE DLTTQIVPES IRLNRDLAVG 

        70         80         90        100        110        120 
DNVSEAEGLA YIRQIADKNK VFKSYIGMGY YGTEVPSVIQ RNVLENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQLSMDLTG LDLASSSLLD EATAAAEAMA LAKRVSKAKK ANIFFVADDV 

       190        200        210        220        230        240 
FPQTLDVIKT RAECFGMEVV VGPAEEAVNY ELFGALFQYT NRYGQITDFT ELFTALHEKK 

       250        260        270        280        290        300 
AIISVAADIM SLVMLKSPGS MGADVVFGNS QRFGVPMGFG GPHAAFFVSR DAHKRSLPGR 

       310        320        330        340        350        360 
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV FHGPQGLKVI 

       370        380        390        400        410        420 
AERIHRLTDI LAAGLTAKGV ELVNNTWFDT LSIKGLDAKA VQKRADAAGI NLRVDSCSES 

       430        440        450        460        470        480 
DGSSDQVLGV SLAETTTRTD VTQLFDVILG EGHGLDVAAL DAQVMADSTS VPAELVRQDA 

       490        500        510        520        530        540 
ILTHPTFNRY HSETEMMRYI KRLENKDLAL NHSMISLGSC TMKLNAATEM MPITWPEFGN 

       550        560        570        580        590        600 
MHPFCPQDQA QGYAQLLGEL SEWLVDITGY DAVSLQPNSG AQGEYAGLLA IKQYHESRGD 

       610        620        630        640        650        660 
AHRNICLIPS SAHGTNPASA QLAGMKIVVT ACDKAGNIDM EDLKAKAAEV ADNLSCIMVT 

       670        680        690        700        710        720 
YPSTHGVYEE TIGEICEVIH QHGGQVYLDG ANMNAQVGLT SPGFIGADVS HLNLHKTFAI 

       730        740        750        760        770        780 
PHGGGGPGMG PIGVKKHLAP FLSGHSVVKH GLESDGNGAV SAAPYGSAGI LPITWMYIKL 

       790        800        810        820        830        840 
LGKQGLREST QVALLNANYM MKKLSEHYPV LYTGRNDRVA HECIIDLRPL KEASGVTEMD 

       850        860        870        880        890        900 
IAKRLNDYGF HAPTMSFPVA GTLMIEPTES ESKVELDRFI EAMVSIRAEA ARVESGEWPV 

       910        920        930        940        950        960 
DNNPLHNAPH TLADIMDPEF DSRPYSREVA VFPTAAVKQN KFWPTVNRID DVYGDRNLFC 


ACVPISDYE 

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References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000961 Genomic DNA. Translation: ACA88224.1.
RefSeqYP_001762319.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KG87.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING392500.Swoo_3967.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA88224; ACA88224; Swoo_3967.
GeneID6118316.
KEGGswd:Swoo_3967.
PATRIC23610597. VBISheWoo126588_4084.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSWOO392500:GI2C-4100-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEWM
AccessionPrimary (citable) accession number: B1KG87
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families