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B1KG87

- GCSP_SHEWM

UniProt

B1KG87 - GCSP_SHEWM

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSWOO392500:GI2C-4100-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Swoo_3967
    OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
    Taxonomic identifieri392500 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000002168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 969969Glycine dehydrogenase (decarboxylating)PRO_1000132456Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei716 – 7161N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi392500.Swoo_3967.

    Structurei

    3D structure databases

    ProteinModelPortaliB1KG87.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1KG87-1 [UniParc]FASTAAdd to Basket

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    MTTETLTTLE QHDRFLGRHI GPDSEQRQEM LNYVGAESLE DLTTQIVPES    50
    IRLNRDLAVG DNVSEAEGLA YIRQIADKNK VFKSYIGMGY YGTEVPSVIQ 100
    RNVLENPGWY TAYTPYQPEI AQGRLEAILN FQQLSMDLTG LDLASSSLLD 150
    EATAAAEAMA LAKRVSKAKK ANIFFVADDV FPQTLDVIKT RAECFGMEVV 200
    VGPAEEAVNY ELFGALFQYT NRYGQITDFT ELFTALHEKK AIISVAADIM 250
    SLVMLKSPGS MGADVVFGNS QRFGVPMGFG GPHAAFFVSR DAHKRSLPGR 300
    IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
    FHGPQGLKVI AERIHRLTDI LAAGLTAKGV ELVNNTWFDT LSIKGLDAKA 400
    VQKRADAAGI NLRVDSCSES DGSSDQVLGV SLAETTTRTD VTQLFDVILG 450
    EGHGLDVAAL DAQVMADSTS VPAELVRQDA ILTHPTFNRY HSETEMMRYI 500
    KRLENKDLAL NHSMISLGSC TMKLNAATEM MPITWPEFGN MHPFCPQDQA 550
    QGYAQLLGEL SEWLVDITGY DAVSLQPNSG AQGEYAGLLA IKQYHESRGD 600
    AHRNICLIPS SAHGTNPASA QLAGMKIVVT ACDKAGNIDM EDLKAKAAEV 650
    ADNLSCIMVT YPSTHGVYEE TIGEICEVIH QHGGQVYLDG ANMNAQVGLT 700
    SPGFIGADVS HLNLHKTFAI PHGGGGPGMG PIGVKKHLAP FLSGHSVVKH 750
    GLESDGNGAV SAAPYGSAGI LPITWMYIKL LGKQGLREST QVALLNANYM 800
    MKKLSEHYPV LYTGRNDRVA HECIIDLRPL KEASGVTEMD IAKRLNDYGF 850
    HAPTMSFPVA GTLMIEPTES ESKVELDRFI EAMVSIRAEA ARVESGEWPV 900
    DNNPLHNAPH TLADIMDPEF DSRPYSREVA VFPTAAVKQN KFWPTVNRID 950
    DVYGDRNLFC ACVPISDYE 969
    Length:969
    Mass (Da):105,773
    Last modified:April 29, 2008 - v1
    Checksum:i77986D152BDE4B80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA88224.1.
    RefSeqiYP_001762319.1. NC_010506.1.

    Genome annotation databases

    EnsemblBacteriaiACA88224; ACA88224; Swoo_3967.
    GeneIDi6118316.
    KEGGiswd:Swoo_3967.
    PATRICi23610597. VBISheWoo126588_4084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000961 Genomic DNA. Translation: ACA88224.1 .
    RefSeqi YP_001762319.1. NC_010506.1.

    3D structure databases

    ProteinModelPortali B1KG87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 392500.Swoo_3967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA88224 ; ACA88224 ; Swoo_3967 .
    GeneIDi 6118316.
    KEGGi swd:Swoo_3967.
    PATRICi 23610597. VBISheWoo126588_4084.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SWOO392500:GI2C-4100-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51908 / MS32.

    Entry informationi

    Entry nameiGCSP_SHEWM
    AccessioniPrimary (citable) accession number: B1KG87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3