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B1KDW0

- SYL_SHEWM

UniProt

B1KDW0 - SYL_SHEWM

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Protein
Leucine--tRNA ligase
Gene
leuS, Swoo_3702
Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-3829-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Swoo_3702
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligaseUniRule annotation
PRO_1000091363Add
BLAST

Proteomic databases

PRIDEiB1KDW0.

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_3702.

Structurei

3D structure databases

ProteinModelPortaliB1KDW0.
SMRiB1KDW0. Positions 228-412.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi618 – 6225"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KDW0-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYQPSEI EAKVQQHWQD TKTFEVTEDE NKEKFYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA IKNSSAPAPW 100
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
KKTASVNWCP NDETVLANEQ VQDGCCWRCD TEVVQKEIPQ WFIKITDYAD 200
ELLSDIDQLD EWPEQVKTMQ RNWIGRSEGI EMTFQVADSD ESFDIYTTRP 250
DTVMGVTYVA IAAGHPLAEK AAANSPELAA FIEECKNADT TEAAMAAMEK 300
KGVATGLYAI HPLTGKQVPI WAANFVLMNY GTGAVMSVPA HDQRDYEFAI 350
KYGLAIEGVI KPEDAELDIS EEAYTEKGVL FNSAEFDGLD FQAAFDAIDA 400
KLTAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLADGT VVPTPEDQLP 450
VILPEDVVMD GIQSPIKADK EWAKTQINGE DALRETDTFD TFMESSWYYA 500
RYCSPHADEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDIG 550
LVNSDEPAKR LLTQGMVLAD AYYYTNEKGA RVWVSPADVT VQETDDKGRT 600
VKAVDSHGNE LVYTGMSKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFAAP 650
PELTLEWQES SVEGAHRFIK RLWKVAHDHV AKGTTVSLDV KSLDAKQKEL 700
RRELHKTIAK VGDDIERRQM FNTAIASVME LMNRLQKAPT ETEQDRALMQ 750
EALSAVVRLL YPIIPHTSFS LWKELGNEEN IEDVRWPEAD ESALVEDSKL 800
IIVQVNGKLR AKITVPADAT KEAVEAQGFA EEGVIKHTEG KTVRKVIYVP 850
GKLLNIVAN 859
Length:859
Mass (Da):97,372
Last modified:April 29, 2008 - v1
Checksum:iF83A898A01DEE481
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA87962.1.
RefSeqiYP_001762057.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA87962; ACA87962; Swoo_3702.
GeneIDi6118046.
KEGGiswd:Swoo_3702.
PATRICi23610049. VBISheWoo126588_3815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000961 Genomic DNA. Translation: ACA87962.1 .
RefSeqi YP_001762057.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KDW0.
SMRi B1KDW0. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_3702.

Proteomic databases

PRIDEi B1KDW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA87962 ; ACA87962 ; Swoo_3702 .
GeneIDi 6118046.
KEGGi swd:Swoo_3702.
PATRICi 23610049. VBISheWoo126588_3815.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SWOO392500:GI2C-3829-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiSYL_SHEWM
AccessioniPrimary (citable) accession number: B1KDW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi