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B1KDW0

- SYL_SHEWM

UniProt

B1KDW0 - SYL_SHEWM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella woodyi (strain ATCC 51908 / MS32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSWOO392500:GI2C-3829-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Swoo_3702
OrganismiShewanella woodyi (strain ATCC 51908 / MS32)
Taxonomic identifieri392500 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000002168: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_1000091363Add
BLAST

Proteomic databases

PRIDEiB1KDW0.

Interactioni

Protein-protein interaction databases

STRINGi392500.Swoo_3702.

Structurei

3D structure databases

ProteinModelPortaliB1KDW0.
SMRiB1KDW0. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1KDW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYQPSEI EAKVQQHWQD TKTFEVTEDE NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVARYQRLQG KNVLQPIGWD SFGLPAENAA IKNSSAPAPW
110 120 130 140 150
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTASVNWCP NDETVLANEQ VQDGCCWRCD TEVVQKEIPQ WFIKITDYAD
210 220 230 240 250
ELLSDIDQLD EWPEQVKTMQ RNWIGRSEGI EMTFQVADSD ESFDIYTTRP
260 270 280 290 300
DTVMGVTYVA IAAGHPLAEK AAANSPELAA FIEECKNADT TEAAMAAMEK
310 320 330 340 350
KGVATGLYAI HPLTGKQVPI WAANFVLMNY GTGAVMSVPA HDQRDYEFAI
360 370 380 390 400
KYGLAIEGVI KPEDAELDIS EEAYTEKGVL FNSAEFDGLD FQAAFDAIDA
410 420 430 440 450
KLTAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLADGT VVPTPEDQLP
460 470 480 490 500
VILPEDVVMD GIQSPIKADK EWAKTQINGE DALRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPHADEM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDIG
560 570 580 590 600
LVNSDEPAKR LLTQGMVLAD AYYYTNEKGA RVWVSPADVT VQETDDKGRT
610 620 630 640 650
VKAVDSHGNE LVYTGMSKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFAAP
660 670 680 690 700
PELTLEWQES SVEGAHRFIK RLWKVAHDHV AKGTTVSLDV KSLDAKQKEL
710 720 730 740 750
RRELHKTIAK VGDDIERRQM FNTAIASVME LMNRLQKAPT ETEQDRALMQ
760 770 780 790 800
EALSAVVRLL YPIIPHTSFS LWKELGNEEN IEDVRWPEAD ESALVEDSKL
810 820 830 840 850
IIVQVNGKLR AKITVPADAT KEAVEAQGFA EEGVIKHTEG KTVRKVIYVP

GKLLNIVAN
Length:859
Mass (Da):97,372
Last modified:April 29, 2008 - v1
Checksum:iF83A898A01DEE481
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA87962.1.
RefSeqiYP_001762057.1. NC_010506.1.

Genome annotation databases

EnsemblBacteriaiACA87962; ACA87962; Swoo_3702.
GeneIDi6118046.
KEGGiswd:Swoo_3702.
PATRICi23610049. VBISheWoo126588_3815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000961 Genomic DNA. Translation: ACA87962.1 .
RefSeqi YP_001762057.1. NC_010506.1.

3D structure databases

ProteinModelPortali B1KDW0.
SMRi B1KDW0. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 392500.Swoo_3702.

Proteomic databases

PRIDEi B1KDW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA87962 ; ACA87962 ; Swoo_3702 .
GeneIDi 6118046.
KEGGi swd:Swoo_3702.
PATRICi 23610049. VBISheWoo126588_3815.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SWOO392500:GI2C-3829-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51908 / MS32.

Entry informationi

Entry nameiSYL_SHEWM
AccessioniPrimary (citable) accession number: B1KDW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3