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B1KCZ2 (B1KCZ2_SHEWM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-ketoacyl-CoA thiolase HAMAP MF_01620
EC=2.3.1.16 HAMAP MF_01620
Alternative name(s):
Acetyl-CoA acyltransferase HAMAP MF_01620
Beta-ketothiolase HAMAP MF_01620
Fatty acid oxidation complex subunit beta HAMAP MF_01620
Gene names
Name:fadA HAMAP MF_01620
Ordered Locus Names:Swoo_0020
OrganismShewanella woodyi (strain ATCC 51908 / MS32) [Complete proteome] [HAMAP] EMBL ACA84321.1
Taxonomic identifier392500 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed By similarity. HAMAP MF_01620

Catalytic activity

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. HAMAP MF_01620 SAAS SAAS020613

Pathway

Lipid metabolism; fatty acid beta-oxidation. HAMAP MF_01620 SAAS SAAS020613

Subunit structure

Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity. HAMAP MF_01620 SAAS SAAS020613

Subcellular location

Cytoplasm By similarity HAMAP MF_01620.

Sequence similarities

Belongs to the thiolase family. HAMAP MF_01620

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site911Acyl-thioester intermediate By similarity HAMAP MF_01620
Active site3431Proton acceptor By similarity HAMAP MF_01620
Active site3731Proton acceptor By similarity HAMAP MF_01620

Sequences

Sequence LengthMass (Da)Tools
B1KCZ2 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 051AE158464E8F44

FASTA38740,828
        10         20         30         40         50         60 
MKQAVIVDCI RTPMGRSKAG VFRNVRAETL SAELMKALLA RNPKLDPKDI EDVIWGCVQQ 

        70         80         90        100        110        120 
TLEQGFNIAR NAALLAGIPK EAGAVTVNRL CGSSMDALHQ AARAIMTGQG DTFIIGGVEH 

       130        140        150        160        170        180 
MGHVPMNHGV DFHPGLANNV AKASGMMGLT AEMLGKMHGI SREQQDEFAV RSHQRAHAAT 

       190        200        210        220        230        240 
VEGRFANEIH PVEGHDANGV LIKVEHDEVI RPETSMESLS GLRPAFDPAN GTVTAGTSSA 

       250        260        270        280        290        300 
LSDGASAMLV MEEEKAKALG LPIRARIRSM AVAGCDAAIM GYGPVPATKK ALERAGLTID 

       310        320        330        340        350        360 
DLDVIELNEA FAAQSLPCVK DLGLMDVVDE KINLNGGAIA LGHPLGCSGA RISTTLINLM 

       370        380 
EAKDAKYGLA TMCIGLGQGI ATVFERP

« Hide

References

[1]"Complete sequence of Shewanella woodyi ATCC 51908."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Lykidis A., Zhao J.-S., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51908 / MS32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000961 Genomic DNA. Translation: ACA84321.1.
RefSeqYP_001758416.1. NC_010506.1.

3D structure databases

ProteinModelPortalB1KCZ2.
SMRB1KCZ2. Positions 2-386.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1KCZ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6114237.
GenomeReviewsGene locus Swoo_0020 in contig CP000961_GR.
KEGGswd:Swoo_0020.
PATRIC23602219. VBISheWoo126588_0020.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG370930.
OMASSMEAIH.
ProtClustDBPRK08947.

Family and domain databases

HAMAPMF_01620. FadA.
[Tree]
InterProIPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00632.
PANTHERPTHR18919:SF35. PTHR18919:SF35. 1 hit.
PTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. FadA. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1KCZ2_SHEWM
AccessionPrimary (citable) accession number: B1KCZ2
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info