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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Transition state stabilizerUniRule annotation1
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi255Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:Bcenmc03_5078
OrganismiBurkholderia cenocepacia (strain MC0-3)
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002169 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547371 – 728Catalase-peroxidase 2Add BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91 ↔ 214Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-240)UniRule annotation
Cross-linki214 ↔ 240Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB1K6I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiEICERET.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1K6I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEGKCPFN HGKRNGTTNR DWWPNQLNLK ILHQHSSEAD PMDPGFDYAE
60 70 80 90 100
AFNSLDLAAV KADLRALMTA SQDWWPADFG HYGPFFVRMA WHSAGTYRTG
110 120 130 140 150
DGRGGAGRGQ QRFAPLNSWP DNVGLDKARR LIWPVKQKYG RKISWADLIV
160 170 180 190 200
LTGNVALESM GFKTFGFAGG REDSWEPDED VYWGMESTWL DDKRYSGDRQ
210 220 230 240 250
LETPLAAVQM GLIYVNPEGP NGNPDPLASA RDIRETFARM AMNDEETVAL
260 270 280 290 300
IAGGHTFGKT HGAGDASHVG PEPEAAPLEQ MGLGWKSSFG SGKAGDAIGS
310 320 330 340 350
GLEVIWTSTP TQWSNNFFWN LFGYDWELTK SPAGAHQWQP KGGAGADSVP
360 370 380 390 400
DPFEPGKRRV PTMLTSDIAL RADPTYEKIS RRFFENPNEF AEAFARAWFK
410 420 430 440 450
LTHRDMGPRV RYLGPEVPSE ELLWQDPIPM PDHPQVDEQD VSALKAKVLA
460 470 480 490 500
SGLSVSELVS TAWASASTFR GSDKRGGANG ARVRLAPQKD WEVNQPAQLA
510 520 530 540 550
TVLEVLGALQ VEFNRAATGG KQVSLADLIV IAGNAGVEQA AAAAGVEITV
560 570 580 590 600
PFTPGRGDAS AEQTDVDSMA VLEPIADGFR NYLKGAYTIP AEKLLIDKAQ
610 620 630 640 650
LLSLSAPEMT VLIGGLRVLG TNVGDSKHGV FTDRREVLTN DFFRNLLDMG
660 670 680 690 700
TEWKPTSEAN EAYEGRDRAT GELKWLASRV DLVFGSHSQL RALSEVYGSE
710 720
DSQQKFVRDF VAAWTKVMNA DRFDIKHN
Length:728
Mass (Da):79,926
Last modified:April 29, 2008 - v1
Checksum:i24FBBA5BA38AAB9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000959 Genomic DNA. Translation: ACA94208.1.
RefSeqiWP_011546991.1. NC_010515.1.

Genome annotation databases

EnsemblBacteriaiACA94208; ACA94208; Bcenmc03_5078.
KEGGibcm:Bcenmc03_5078.
PATRICi19099822. VBIBurCen61509_6372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000959 Genomic DNA. Translation: ACA94208.1.
RefSeqiWP_011546991.1. NC_010515.1.

3D structure databases

ProteinModelPortaliB1K6I9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA94208; ACA94208; Bcenmc03_5078.
KEGGibcm:Bcenmc03_5078.
PATRICi19099822. VBIBurCen61509_6372.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiEICERET.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_BURCC
AccessioniPrimary (citable) accession number: B1K6I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.