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B1K5N3

- GCH42_BURCC

UniProt

B1K5N3 - GCH42_BURCC

Protein

GTP cyclohydrolase FolE2 2

Gene

folE2-2

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei166 – 1661May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciBCEN406425:GHD9-5015-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2 2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2-2UniRule annotation
    Ordered Locus Names:Bcenmc03_4937
    OrganismiBurkholderia cenocepacia (strain MC0-3)
    Taxonomic identifieri406425 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002169: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316GTP cyclohydrolase FolE2 2PRO_0000372023Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi406425.Bcenmc03_4937.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1K5N3-1 [UniParc]FASTAAdd to Basket

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    MEKALHRISS MNAALPDISL TDAAPGRRPL EWVGMQGIDL PVVVAEPGCR    50
    RDVHARADVQ VDLPAPQVKG IHMSRLYGLL DGLADGEALS PAGLQRMLRA 100
    MVDSHRDCAT RSARVRLRFD LLARRTALVT EGLAGWKAYP VRLDATLSGD 150
    AFALRAQVTV VYSSTCPCSA ALSRHWIEQA FLTAFGHEAR VEPTAVAAWL 200
    KRHATAATPH SQRSEAVVSV ALPADGTTLG LLDLIDRVEQ ALGTPVQTAV 250
    KRADEQAFAV LNGGNLMFVE DAARRVQAAL EDRHASPRVR VRHLESLHPH 300
    DAVAWAAPLR EGADAC 316
    Length:316
    Mass (Da):34,116
    Last modified:May 5, 2009 - v2
    Checksum:iB9DAFA99C8F154D6
    GO

    Sequence cautioni

    The sequence ACA94067.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000959 Genomic DNA. Translation: ACA94067.1. Different initiation.
    RefSeqiYP_001778557.1. NC_010515.1.

    Genome annotation databases

    EnsemblBacteriaiACA94067; ACA94067; Bcenmc03_4937.
    GeneIDi6127749.
    KEGGibcm:Bcenmc03_4937.
    PATRICi19099536. VBIBurCen61509_6234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000959 Genomic DNA. Translation: ACA94067.1 . Different initiation.
    RefSeqi YP_001778557.1. NC_010515.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 406425.Bcenmc03_4937.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA94067 ; ACA94067 ; Bcenmc03_4937 .
    GeneIDi 6127749.
    KEGGi bcm:Bcenmc03_4937.
    PATRICi 19099536. VBIBurCen61509_6234.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci BCEN406425:GHD9-5015-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-3."
      Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC0-3.

    Entry informationi

    Entry nameiGCH42_BURCC
    AccessioniPrimary (citable) accession number: B1K5N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3