B1K3U1 (KHSE_BURCC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Bcenmc03_3660

Organism

Burkholderia cenocepacia (strain MC0-3) [Complete proteome] [HAMAP]

Taxonomic identifier

406425 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Homoserine kinase HAMAP MF_00301		PRO_1000115426

Sequences

	Sequence		Length	Mass (Da)
	B1K3U1 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: CA5E3D0BD59F3755	FASTA	332	37,186
	10 20 30 40 50 60 MAVFTAVSDS DLAQWMRHYE LGDVLAFRGI PSGIENSNFF LTTTRGEYVL TIFEKLTAQQ 70 80 90 100 110 120 LPFYLDLMRH LAAHGVPVPD PIPRDDGALF GELHGKPAAI VTKLDGAAEL APGVEHCIEV 130 140 150 160 170 180 GQMLARLHLA GRDYPRNQPN LRSLPWWQEN VPAIVPFITD AQRALLEGEL AHQAGFFASD 190 200 210 220 230 240 DYAALPAGPC HCDLFRDNVL FAHAAPGTGH DVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 250 260 270 280 290 300 VDLATGVLDV ARADALLRAY QTVRPFTAEE RRHWSDMLRA GAYRFWVSRL YDFYLPRAAE 310 320 330 MLKPHDPGHF ERILRERIAH TPALPEIQTA CN

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-3." Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Tiedje J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC0-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000959 Genomic DNA. Translation: ACA92812.1.
RefSeq	YP_001777302.1. NC_010515.1.
3D structure databases
ProteinModelPortal	B1K3U1.
ModBase	Search...
Protein-protein interaction databases
STRING	B1K3U1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6126494.
GenomeReviews	Gene locus Bcenmc03_3660 in contig CP000959_GR.
KEGG	bcm:Bcenmc03_3660.
PATRIC	19096954. VBIBurCen61509_4946.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BURCC

Accession

Primary (citable) accession number: B1K3U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 29, 2008
Last modified:	January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program