B1K259 (ADC_BURCC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable acetoacetate decarboxylase
Short name=AAD
Short name=ADC
EC=4.1.1.4

Gene names

Name:	adc
Ordered Locus Names:	Bcenmc03_4525

Organism

Burkholderia cenocepacia (strain MC0-3) [Complete proteome] [HAMAP]

Taxonomic identifier

406425 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetoacetate to acetone and carbon dioxide By similarity. HAMAP-Rule MF_00597
Catalytic activity	Acetoacetate = acetone + CO2. HAMAP-Rule MF_00597
Sequence similarities	Belongs to the ADC family.

Ontologies

Keywords
Ligand	Schiff base
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	acetoacetate decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Probable acetoacetate decarboxylase HAMAP-Rule MF_00597		PRO_1000129875
Sites
	Active site	116	1	Schiff-base intermediate with acetoacetate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B1K259 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: B98A02343AAABE49	FASTA	246	27,454
	10 20 30 40 50 60 MKPSDVRSKA FAMPLTSPAF PMGPYRFVDR EFLIITYRTD PDRLREIVPE PLQVTEPLVH 70 80 90 100 110 120 YEFIRMADST GFGDYTESGQ VIPVEYEGQP GGYTLAMYLD DHPPIAGGRE LWGFPKKLAS 130 140 150 160 170 180 PTLHVNTDHI LGTLDYGKVR VATGTMGYKH KELDIDEQTK RLAGPNFLLK IIPHVDGTAR 190 200 210 220 230 240 VCELVRYYMQ DIKMKGAWTG PASLELAPHA LAPVADLPVL EIVEARHLVA DLTLGLGEVV YDYLAQ

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia MC0-3." Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Tiedje J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC0-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000959 Genomic DNA. Translation: ACA93665.1.
RefSeq	YP_001778155.1. NC_010515.1.
3D structure databases
ProteinModelPortal	B1K259.
SMR	B1K259. Positions 4-245.
ModBase	Search...
Protein-protein interaction databases
STRING	406425.Bcenmc03_4525.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACA93665; ACA93665; Bcenmc03_4525.
GeneID	6127347.
KEGG	bcm:Bcenmc03_4525.
PATRIC	19098722. VBIBurCen61509_5827.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4689.
HOGENOM	HOG000063822.
KO	K01574.
OMA	EYLHAMY.
ProtClustDB	PRK02265.
Enzyme and pathway databases
BioCyc	BCEN406425:GHD9-4603-MONOMER.
Family and domain databases
Gene3D	2.40.400.10. 1 hit.
HAMAP	MF_00597. ADC.
InterPro	IPR010451. Acetoacetate_decarboxylase. IPR023653. Acetoacetate_decarboxylase_bac. IPR023375. Acetoacetate_decarboxylase_dom. [Graphical view]
Pfam	PF06314. ADC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADC_BURCC

Accession

Primary (citable) accession number: B1K259

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 29, 2008
Last modified:	May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program