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Protein
Submitted name:

2-oxoglutarate dehydrogenase, E1 subunit

Gene

Bcenmc03_1484

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Enzyme and pathway databases

BioCyciBCEN406425:GHD9-1526-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase, E1 subunitImported (EC:1.2.4.2Imported)
Gene namesi
Ordered Locus Names:Bcenmc03_1484Imported
OrganismiBurkholderia cenocepacia (strain MC0-3)Imported
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002169: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi406425.Bcenmc03_1484.

Structurei

3D structure databases

ProteinModelPortaliB1K0M8.
SMRiB1K0M8. Positions 92-945.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

B1K0M8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDVMKQFQL NSYLFGGNAS YVEELYDAYL NNPASVPENW REYFDALQNV
60 70 80 90 100
PATDGSNAND VAHFPIVESF AERAKANAFI PRESTSNLAT ARKQVHVQSL
110 120 130 140 150
ISAYRFLGSQ WANLDPLKRR ERPAIPELEP AFYDFSEGDL DQTYSASNLY
160 170 180 190 200
FGFDQASLRD IVKGLRDTYC GTIGAEYMYI SDPEQKRWWQ ERLESTRATP
210 220 230 240 250
SFSIEKKKHI LNRLTAAEGL ERYLHTKYVG QKRFSLEGGE SFIAAMDEVV
260 270 280 290 300
QHAGKSGVQE IIIGMAHRGR LNVLVNTLGK MPADLFAEFE GKHVDDLPAG
310 320 330 340 350
DVKYHKGFSS DVSTEGGPVH LSLAFNPSHL EIVNPVVEGS AKARMDRRGD
360 370 380 390 400
EDGLQVLPVQ IHGDAAFAGQ GVVMETLNLA QTRGYGTHGT LHIVINNQIG
410 420 430 440 450
FTTSDPRDAR STLYCTDVVK MIEAPVLHVN GDDPEAVVLA IQIAIDYRMQ
460 470 480 490 500
FHKDVVIDIV CFRKLGHNEQ DTPAVTQPLM YKKIAQHPGT RALYAEKLVQ
510 520 530 540 550
QGVITAEDAD NYVKAYRKAM DDGHHTVDPV LSNYKSKYAV DWVPFLNRKW
560 570 580 590 600
TDAADTAVPL AELKRLGERI TTVPENFKVH PLVERVINDR RNMARGDQPL
610 620 630 640 650
DWGMGEHLAF ASLVASGYSV RLTGQDSGRG TFTHRHAVLH DQNRERWNDG
660 670 680 690 700
TYVPLQNIAD GQAKFTVIDS VLSEEAVLGF EYGYSTAEPN TLVLWEAQFG
710 720 730 740 750
DFVNGAQVVI DQFISSGEVK WGRVSGLTML LPHGYEGQGP EHSSTRIERF
760 770 780 790 800
LQLCADHNMQ VVQPTTPAQI FHLLRRQMIR LFRKPLIVAT PKSLLRHKEA
810 820 830 840 850
VSDLSELAKG SFQPVLGETD GGIDAKKVKR VLACSGRVYY DLVAHRREAK
860 870 880 890 900
ANDVAIIRIE QLYPFAHKQF EAEMKKYENA TEVVWVQDEP QNQGPWFYVE
910 920 930 940 950
HHLKEGMKEG QKLAYSGRPA SASPAVGYYA KHYEQQKALI EGAFGRLKSA

SIAK
Length:954
Mass (Da):106,817
Last modified:April 29, 2008 - v1
Checksum:i3392696FF5977E60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA. Translation: ACA90659.1.
RefSeqiWP_006476158.1. NC_010508.1.
YP_001764781.1. NC_010508.1.

Genome annotation databases

EnsemblBacteriaiACA90659; ACA90659; Bcenmc03_1484.
GeneIDi6123162.
KEGGibcm:Bcenmc03_1484.
PATRICi19090034. VBIBurCen61509_1533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA. Translation: ACA90659.1.
RefSeqiWP_006476158.1. NC_010508.1.
YP_001764781.1. NC_010508.1.

3D structure databases

ProteinModelPortaliB1K0M8.
SMRiB1K0M8. Positions 92-945.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi406425.Bcenmc03_1484.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA90659; ACA90659; Bcenmc03_1484.
GeneIDi6123162.
KEGGibcm:Bcenmc03_1484.
PATRICi19090034. VBIBurCen61509_1533.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciBCEN406425:GHD9-1526-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3."
    Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC0-3Imported.

Entry informationi

Entry nameiB1K0M8_BURCC
AccessioniPrimary (citable) accession number: B1K0M8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.