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B1K0J5

- FMT_BURCC

UniProt

B1K0J5 - FMT_BURCC

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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciBCEN406425:GHD9-3217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Bcenmc03_3142
OrganismiBurkholderia cenocepacia (strain MC0-3)
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002169: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Methionyl-tRNA formyltransferasePRO_1000098384Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406425.Bcenmc03_3142.

Structurei

3D structure databases

ProteinModelPortaliB1K0J5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni121 – 1244Tetrahydrofolate (THF) bindingUniRule annotation

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
KOiK00604.
OMAiRGDWFTP.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1K0J5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTHTLRVIFA GTPEFAAAAL AAIHKAGFPV PLVLTQPDRP AGRGMKLQAS
60 70 80 90 100
AVKRYAVEHG MAVAQPPSLR RAGKYPAEAA DAIELLRTTP HDVMVVAAYG
110 120 130 140 150
LLLPQEVLDI PRAGCINIHA SLLPRWRGAA PIHRAIEAGD AETGVTLMQM
160 170 180 190 200
DVGLDTGAMI EEARIAIAPD DTTATLHDRL AAAGARLIVD ALVRLERDGT
210 220 230 240 250
LPATPQPADG VTYAEKIGKH EAALDWRKPA DVLARQVRAF DPFPGGVATL
260 270 280 290 300
DGAAIKLWAA EPVAAHGTIA TAAPGTIVEA APEGVVVACG SGALRVTQLQ
310 320 330
KPGGKRLPAR EFLAGSPLAA GQRFALPDVD
Length:330
Mass (Da):34,405
Last modified:April 29, 2008 - v1
Checksum:iC12C58BD62CD8345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA. Translation: ACA92300.1.
RefSeqiWP_012329437.1. NC_010508.1.
YP_001766422.1. NC_010508.1.

Genome annotation databases

EnsemblBacteriaiACA92300; ACA92300; Bcenmc03_3142.
GeneIDi6124803.
KEGGibcm:Bcenmc03_3142.
PATRICi19093578. VBIBurCen61509_3268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA. Translation: ACA92300.1 .
RefSeqi WP_012329437.1. NC_010508.1.
YP_001766422.1. NC_010508.1.

3D structure databases

ProteinModelPortali B1K0J5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406425.Bcenmc03_3142.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA92300 ; ACA92300 ; Bcenmc03_3142 .
GeneIDi 6124803.
KEGGi bcm:Bcenmc03_3142.
PATRICi 19093578. VBIBurCen61509_3268.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
KOi K00604.
OMAi RGDWFTP.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci BCEN406425:GHD9-3217-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
PROSITEi PS00373. GART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3."
    Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC0-3.

Entry informationi

Entry nameiFMT_BURCC
AccessioniPrimary (citable) accession number: B1K0J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3