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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciBCEN406425:G1GBC-3342-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Bcenmc03_3142
OrganismiBurkholderia cenocepacia (strain MC0-3)
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002169 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000983841 – 330Methionyl-tRNA formyltransferaseAdd BLAST330

Structurei

3D structure databases

ProteinModelPortaliB1K0J5
SMRiB1K0J5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 124Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B1K0J5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHTLRVIFA GTPEFAAAAL AAIHKAGFPV PLVLTQPDRP AGRGMKLQAS
60 70 80 90 100
AVKRYAVEHG MAVAQPPSLR RAGKYPAEAA DAIELLRTTP HDVMVVAAYG
110 120 130 140 150
LLLPQEVLDI PRAGCINIHA SLLPRWRGAA PIHRAIEAGD AETGVTLMQM
160 170 180 190 200
DVGLDTGAMI EEARIAIAPD DTTATLHDRL AAAGARLIVD ALVRLERDGT
210 220 230 240 250
LPATPQPADG VTYAEKIGKH EAALDWRKPA DVLARQVRAF DPFPGGVATL
260 270 280 290 300
DGAAIKLWAA EPVAAHGTIA TAAPGTIVEA APEGVVVACG SGALRVTQLQ
310 320 330
KPGGKRLPAR EFLAGSPLAA GQRFALPDVD
Length:330
Mass (Da):34,405
Last modified:April 29, 2008 - v1
Checksum:iC12C58BD62CD8345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA Translation: ACA92300.1
RefSeqiWP_012329437.1, NC_010508.1

Genome annotation databases

EnsemblBacteriaiACA92300; ACA92300; Bcenmc03_3142
KEGGibcm:Bcenmc03_3142

Similar proteinsi

Entry informationi

Entry nameiFMT_BURCC
AccessioniPrimary (citable) accession number: B1K0J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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