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B1JY80

- PNCB_BURCC

UniProt

B1JY80 - PNCB_BURCC

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBCEN406425:GHD9-1093-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:Bcenmc03_1059
    OrganismiBurkholderia cenocepacia (strain MC0-3)
    Taxonomic identifieri406425 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002169: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Nicotinate phosphoribosyltransferasePRO_1000129464Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi406425.Bcenmc03_1059.

    Structurei

    3D structure databases

    ProteinModelPortaliB1JY80.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1JY80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIITSLLDTD LYKFTMMQVV LHHFPAANVE YRFRCRTPGV DLVPYIDEIR    50
    DEVRGLCSLR FVDVELDYLR RMRFIKSDFV DFLALFHLNE KYISITPSPK 100
    GNGEIDIVIE GPWLHTILFE IPVLAIVNEV YFRNTQREPD YREGRERLRE 150
    KIKLLGAKPE FADCKIADYG TRRRFSKVWH EEVALTLRDG LGPQFAGTSN 200
    VLYAMKHDIT PLGTMAHEYL QACQALGPRL RDSQIYGFEM WAKEYRGDLG 250
    IALSDVYGMD AFLNDFDMYF CKLFDGARHD SGDPFEWGER MLRHYEANRC 300
    DPRTKVLVFS DALDIPKVMQ LYERFRGRCK LAFGVGTNLT NDLGYVPLQI 350
    VIKMVRCNGQ PVAKLSDSPG KSMCDDKAYL AYLRQVFGIA QPVEEDASK 399
    Length:399
    Mass (Da):46,044
    Last modified:April 29, 2008 - v1
    Checksum:iA4F700CB3F830787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000958 Genomic DNA. Translation: ACA90236.1.
    RefSeqiYP_001764358.1. NC_010508.1.

    Genome annotation databases

    EnsemblBacteriaiACA90236; ACA90236; Bcenmc03_1059.
    GeneIDi6122739.
    KEGGibcm:Bcenmc03_1059.
    PATRICi19089132. VBIBurCen61509_1091.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000958 Genomic DNA. Translation: ACA90236.1 .
    RefSeqi YP_001764358.1. NC_010508.1.

    3D structure databases

    ProteinModelPortali B1JY80.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 406425.Bcenmc03_1059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA90236 ; ACA90236 ; Bcenmc03_1059 .
    GeneIDi 6122739.
    KEGGi bcm:Bcenmc03_1059.
    PATRICi 19089132. VBIBurCen61509_1091.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BCEN406425:GHD9-1093-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3."
      Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
      , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MC0-3.

    Entry informationi

    Entry nameiPNCB_BURCC
    AccessioniPrimary (citable) accession number: B1JY80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3