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Protein

Kynurenine formamidase

Gene

kynB

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTryptophan catabolism

Enzyme and pathway databases

BioCyciBCEN406425:G1GBC-2773-MONOMER
UniPathwayiUPA00333; UER00454

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:Bcenmc03_2601
OrganismiBurkholderia cenocepacia (strain MC0-3)
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002169 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003621011 – 213Kynurenine formamidaseAdd BLAST213

Structurei

3D structure databases

ProteinModelPortaliB1JXI7
SMRiB1JXI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cyclase 1 superfamily. KynB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000219455
KOiK07130
OMAiCPVNVGR
OrthoDBiPOG091H0N8N

Family and domain databases

Gene3Di3.50.30.50, 1 hit
HAMAPiMF_01969 KynB, 1 hit
InterProiView protein in InterPro
IPR007325 KFase
IPR037175 KFase_sf
IPR017484 Kynurenine_formamidase_bac
PfamiView protein in Pfam
PF04199 Cyclase, 1 hit
SUPFAMiSSF102198 SSF102198, 1 hit
TIGRFAMsiTIGR03035 trp_arylform, 1 hit

Sequencei

Sequence statusi: Complete.

B1JXI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLWDISPP VSPATPVWPG DTPVAVERVW RMEAGSPVNV ARLTLSPHTG
60 70 80 90 100
AHCDAPLHYD ADGAPIGAVP LDTYLGPCRV IHCIGASPVV RPADVEVALD
110 120 130 140 150
GVPPRVLLRT YARAAVEQWD SAFCAVAPDT VDLLAAHGVK LIGIDTPSLD
160 170 180 190 200
PQESKTMDAH HRVRAHRMAI LEGIVLDDVP PGDYELIALP LKFATLDASP
210
VRAVLRALPA HAS
Length:213
Mass (Da):22,662
Last modified:April 29, 2008 - v1
Checksum:iEDFC1F20167A178B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA Translation: ACA91762.1
RefSeqiWP_012329112.1, NC_010508.1

Genome annotation databases

EnsemblBacteriaiACA91762; ACA91762; Bcenmc03_2601
KEGGibcm:Bcenmc03_2601

Similar proteinsi

Entry informationi

Entry nameiKYNB_BURCC
AccessioniPrimary (citable) accession number: B1JXI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 29, 2008
Last modified: April 25, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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