Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kynurenine formamidase

Gene

kynB

Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathway:iL-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Tryptophan catabolism

Enzyme and pathway databases

BioCyciBCEN406425:GHD9-2673-MONOMER.
UniPathwayiUPA00333; UER00454.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:Bcenmc03_2601
OrganismiBurkholderia cenocepacia (strain MC0-3)
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002169 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Kynurenine formamidasePRO_0000362101Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB1JXI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KynB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1878.
HOGENOMiHOG000219455.
KOiK07130.
OMAiFERVPAN.
OrthoDBiEOG67T5JJ.

Family and domain databases

HAMAPiMF_01969. KynB.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.

Sequencei

Sequence statusi: Complete.

B1JXI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTLWDISPP VSPATPVWPG DTPVAVERVW RMEAGSPVNV ARLTLSPHTG
60 70 80 90 100
AHCDAPLHYD ADGAPIGAVP LDTYLGPCRV IHCIGASPVV RPADVEVALD
110 120 130 140 150
GVPPRVLLRT YARAAVEQWD SAFCAVAPDT VDLLAAHGVK LIGIDTPSLD
160 170 180 190 200
PQESKTMDAH HRVRAHRMAI LEGIVLDDVP PGDYELIALP LKFATLDASP
210
VRAVLRALPA HAS
Length:213
Mass (Da):22,662
Last modified:April 29, 2008 - v1
Checksum:iEDFC1F20167A178B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA. Translation: ACA91762.1.
RefSeqiWP_012329112.1. NC_010508.1.

Genome annotation databases

EnsemblBacteriaiACA91762; ACA91762; Bcenmc03_2601.
KEGGibcm:Bcenmc03_2601.
PATRICi19092434. VBIBurCen61509_2700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000958 Genomic DNA. Translation: ACA91762.1.
RefSeqiWP_012329112.1. NC_010508.1.

3D structure databases

ProteinModelPortaliB1JXI7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA91762; ACA91762; Bcenmc03_2601.
KEGGibcm:Bcenmc03_2601.
PATRICi19092434. VBIBurCen61509_2700.

Phylogenomic databases

eggNOGiCOG1878.
HOGENOMiHOG000219455.
KOiK07130.
OMAiFERVPAN.
OrthoDBiEOG67T5JJ.

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454.
BioCyciBCEN406425:GHD9-2673-MONOMER.

Family and domain databases

HAMAPiMF_01969. KynB.
InterProiIPR007325. KFase.
IPR017484. Kynurenine_formamidase_bac.
[Graphical view]
PfamiPF04199. Cyclase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03035. trp_arylform. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3."
    Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC0-3.

Entry informationi

Entry nameiKYNB_BURCC
AccessioniPrimary (citable) accession number: B1JXI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 29, 2008
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.