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B1JVV6

- PUR9_BURCC

UniProt

B1JVV6 - PUR9_BURCC

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Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, Bcenmc03_0658
Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBCEN406425:GHD9-681-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Bcenmc03_0658
OrganismiBurkholderia cenocepacia (strain MC0-3)
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002169: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000096044Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi406425.Bcenmc03_0658.

Structurei

3D structure databases

ProteinModelPortaliB1JVV6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B1JVV6-1 [UniParc]FASTAAdd to Basket

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MIKQALISVS DKTGIVDFAK SLSDLGVKLL STGGTAKLLA DAGLPVTEVA    50
DYTGFPEMLD GRVKTLHPKV HGGILARRDL PEHMQALEQH GIPTIDLLVV 100
NLYPFVATIA KDDCTLADAI ENIDIGGPTM LRSAAKNHRD VTVVVDPADY 150
AVVLDEMKAN GNTVGYPTNF RLATKVFAHT AQYDGAITNY LTSLTDELQH 200
ASRSTYPATL NLAFDKVQDL RYGENPHQSA AFYRDLATPA GALANYRQLQ 250
GKELSYNNIA DSDAAWECVK TFDAPACVII KHANPCGVAV GNDSADAYAK 300
AFQTDPTSAF GGIIAFNREV DEAAAQAVAK QFVEVLIAPS FSDAAKQVFA 350
AKQNVRLLEI ALGDGHNAFD LKRVGGGLLV QSLDSRNVQP SELRVVTKRQ 400
PTAKEMDDLL FAWRVAKYVK SNAIVFCGNG MTLGVGAGQM SRVDSARIAS 450
IKAQNAGLTL AGSAVASDAF FPFRDGLDVV VAAGATCVIQ PGGSMRDDEV 500
IAAADEHGIA MVLTGVRHFR H 521
Length:521
Mass (Da):55,547
Last modified:April 29, 2008 - v1
Checksum:iBF83396FD7616BAE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000958 Genomic DNA. Translation: ACA89836.1.
RefSeqiWP_012327908.1. NC_010508.1.
YP_001763958.1. NC_010508.1.

Genome annotation databases

EnsemblBacteriaiACA89836; ACA89836; Bcenmc03_0658.
GeneIDi6122339.
KEGGibcm:Bcenmc03_0658.
PATRICi19088286. VBIBurCen61509_0679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000958 Genomic DNA. Translation: ACA89836.1 .
RefSeqi WP_012327908.1. NC_010508.1.
YP_001763958.1. NC_010508.1.

3D structure databases

ProteinModelPortali B1JVV6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406425.Bcenmc03_0658.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA89836 ; ACA89836 ; Bcenmc03_0658 .
GeneIDi 6122339.
KEGGi bcm:Bcenmc03_0658.
PATRICi 19088286. VBIBurCen61509_0679.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BCEN406425:GHD9-681-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3."
    Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC0-3.

Entry informationi

Entry nameiPUR9_BURCC
AccessioniPrimary (citable) accession number: B1JVV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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