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B1JTV0

- B1JTV0_BURCC

UniProt

B1JTV0 - B1JTV0_BURCC

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Protein
ATP-dependent Clp protease proteolytic subunit
Gene
clpP, Bcenmc03_1946
Organism
Burkholderia cenocepacia (strain MC0-3)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu-and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei121 – 1211Nucleophile By similarityUniRule annotation
Active sitei146 – 1461 By similarityUniRule annotation

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BioCyciBCEN406425:GHD9-1996-MONOMER.

Protein family/group databases

MEROPSiS14.001.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp
Gene namesi
Name:clpPUniRule annotation
Ordered Locus Names:Bcenmc03_1946Imported
OrganismiBurkholderia cenocepacia (strain MC0-3)Imported
Taxonomic identifieri406425 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002169: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi406425.Bcenmc03_1946.

Structurei

3D structure databases

ProteinModelPortaliB1JTV0.
SMRiB1JTV0. Positions 25-216.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0740.
HOGENOMiHOG000285833.
KOiK01358.
OMAiKGERSFD.
OrthoDBiEOG6Z3KQ0.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_00444. ClpP.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00493. clpP. 1 hit.
PROSITEiPS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1JTV0-1 [UniParc]FASTAAdd to Basket

« Hide

MITRAELLDM LASNAPQGFE AQALGLVPIV VETSGRGERS YDIYSRLLKE    50
RLVFMVGEVN DQTANLVVAQ LLFLESENPD KDISLYINSP GGSVSAGMAI 100
YDTMQFIKPD VSTLCMGLAA SMGAFLLASG AKGKRFALPN SRVMIHQPLG 150
GARGQASDIE IQAREILYLK ERLNNLLAQH TGQDVERIAR DTDRDNFMSS 200
EDAKAYGLID QVLLKRP 217
Length:217
Mass (Da):23,750
Last modified:April 29, 2008 - v1
Checksum:i924F3B6062C85117
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000958 Genomic DNA. Translation: ACA91107.1.
RefSeqiYP_001765229.1. NC_010508.1.

Genome annotation databases

EnsemblBacteriaiACA91107; ACA91107; Bcenmc03_1946.
GeneIDi6123610.
KEGGibcm:Bcenmc03_1946.
PATRICi19091005. VBIBurCen61509_2008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000958 Genomic DNA. Translation: ACA91107.1 .
RefSeqi YP_001765229.1. NC_010508.1.

3D structure databases

ProteinModelPortali B1JTV0.
SMRi B1JTV0. Positions 25-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 406425.Bcenmc03_1946.

Protein family/group databases

MEROPSi S14.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA91107 ; ACA91107 ; Bcenmc03_1946 .
GeneIDi 6123610.
KEGGi bcm:Bcenmc03_1946.
PATRICi 19091005. VBIBurCen61509_2008.

Phylogenomic databases

eggNOGi COG0740.
HOGENOMi HOG000285833.
KOi K01358.
OMAi KGERSFD.
OrthoDBi EOG6Z3KQ0.

Enzyme and pathway databases

BioCyci BCEN406425:GHD9-1996-MONOMER.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_00444. ClpP.
InterProi IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
IPR018215. ClpP_AS.
[Graphical view ]
PANTHERi PTHR10381. PTHR10381. 1 hit.
Pfami PF00574. CLP_protease. 1 hit.
[Graphical view ]
PRINTSi PR00127. CLPPROTEASEP.
SUPFAMi SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR00493. clpP. 1 hit.
PROSITEi PS00382. CLP_PROTEASE_HIS. 1 hit.
PS00381. CLP_PROTEASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3."
    Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L.
    , Kyrpides N., Mikhailova N., Tiedje J., Richardson P.
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MC0-3.

Entry informationi

Entry nameiB1JTV0_BURCC
AccessioniPrimary (citable) accession number: B1JTV0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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