B1JTV0 (B1JTV0_BURCC) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit HAMAP-Rule MF_00444 RuleBase RU003567
EC=3.4.21.92 HAMAP-Rule MF_00444 RuleBase RU000549

Alternative name(s):
Endopeptidase Clp HAMAP-Rule MF_00444

Gene names

Name:	clpP HAMAP-Rule MF_00444
Ordered Locus Names:	Bcenmc03_1946

Organism

Burkholderia cenocepacia (strain MC0-3) [Complete proteome] [HAMAP] EMBL ACA91107.1

Taxonomic identifier

406425 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex › Burkholderia cenocepacia

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP-Rule MF_00444 RuleBase RU000550
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP-Rule MF_00444 RuleBase RU000549
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. HAMAP-Rule MF_00444 RuleBase RU003567

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP-Rule MF_00444
Ligand	ATP-binding HAMAP-Rule MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP-Rule MF_00444 RuleBase RU000549
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	121	1	By similarity HAMAP-Rule MF_00444
	Active site	146	1	By similarity HAMAP-Rule MF_00444

Sequences

	Sequence		Length	Mass (Da)
	B1JTV0 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 924F3B6062C85117	FASTA	217	23,750
	10 20 30 40 50 60 MITRAELLDM LASNAPQGFE AQALGLVPIV VETSGRGERS YDIYSRLLKE RLVFMVGEVN 70 80 90 100 110 120 DQTANLVVAQ LLFLESENPD KDISLYINSP GGSVSAGMAI YDTMQFIKPD VSTLCMGLAA 130 140 150 160 170 180 SMGAFLLASG AKGKRFALPN SRVMIHQPLG GARGQASDIE IQAREILYLK ERLNNLLAQH 190 200 210 TGQDVERIAR DTDRDNFMSS EDAKAYGLID QVLLKRP

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia MC0-3." Copeland A., Lucas S., Lapidus A., Barry K., Bruce D., Goodwin L., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Tiedje J., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MC0-3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000958 Genomic DNA. Translation: ACA91107.1.
RefSeq	YP_001765229.1. NC_010508.1.
3D structure databases
ProteinModelPortal	B1JTV0.
SMR	B1JTV0. Positions 25-216.
ModBase	Search...
Protein-protein interaction databases
STRING	406425.Bcenmc03_1946.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACA91107; ACA91107; Bcenmc03_1946.
GeneID	6123610.
KEGG	bcm:Bcenmc03_1946.
PATRIC	19091005. VBIBurCen61509_2008.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0740.
HOGENOM	HOG000285833.
KO	K01358.
OMA	LVHPPQA.
ProtClustDB	PRK00277.
Enzyme and pathway databases
BioCyc	BCEN406425:GHD9-5842-MONOMER.
Family and domain databases
HAMAP	MF_00444. ClpP.
InterPro	IPR001907. ClpP. IPR023562. ClpP/TepA. IPR018215. ClpP_AS. [Graphical view]
PANTHER	PTHR10381. PTHR10381. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. clpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1JTV0_BURCC

Accession

Primary (citable) accession number: B1JTV0

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)