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B1JQC1

- AAS_YERPY

UniProt

B1JQC1 - AAS_YERPY

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Protein

Bifunctional protein Aas

Gene
aas, YPK_1027
Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 By similarity.UniRule annotation

Catalytic activityi

Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.UniRule annotation
ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361 By similarity

GO - Molecular functioni

  1. acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. long-chain fatty acid [acyl-carrier-protein] ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid metabolic process Source: InterPro
  2. phospholipid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Ligase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-1037-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein Aas
Including the following 2 domains:
2-acylglycerophosphoethanolamine acyltransferase (EC:2.3.1.40)
Alternative name(s):
2-acyl-GPE acyltransferase
Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase
Acyl-[acyl-carrier-protein] synthetase (EC:6.2.1.20)
Alternative name(s):
Acyl-ACP synthetase
Long-chain-fatty-acid--[acyl-carrier-protein] ligase
Gene namesi
Name:aas
Ordered Locus Names:YPK_1027
OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
Taxonomic identifieri502800 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000721: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei258 – 27720Helical; Reviewed predictionAdd
BLAST
Transmembranei409 – 43325Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Bifunctional protein AasUniRule annotationPRO_1000137906Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi502800.YPK_1027.

Structurei

3D structure databases

ProteinModelPortaliB1JQC1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 138124AcyltransferaseUniRule annotationAdd
BLAST
Regioni233 – 646414AMP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000004907.
KOiK05939.
OMAiANWVYLE.
OrthoDBiEOG6KHFVG.

Family and domain databases

HAMAPiMF_01162. Aas.
InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023775. Bifunctional_Aas.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1JQC1-1 [UniParc]FASTAAdd to Basket

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MAYRLLRALF RGLFRVTIDG VTDQFKHEKL IITPNHVSFL DGALLALFLP    50
IKPVFAVYTS ITDTWYMRWL KPYVDFVALD PTNPMAIKHL VRMVEQGRPV 100
VIFPEGRITV TGSLMKIYDG AAFVAAKSGA AVVPIRLDGP EFTHFGRLQG 150
VLKTRWFPKI SIHVLPATTI PMPQAPRSRE RRVLAGEHLH TIMMAARMAT 200
VPRETLFEAL LSAQTRYGRF KPCIEDVSFK EDSYQTLLKK TLGVSRILQR 250
FTVPGEHVGM LLPNATITAA AIFGASLRGR IPALLNYTSG AKGLQSAIIA 300
ASLKTIVTSR QFLEKGKLTH LPEQVNEVNW VYLEDLKDTV TLTDKLWILF 350
HLCFPRRAML PQQADDSALI LFTSGSEGNP KGVVHSHASL LANVEQIRTI 400
ADFTPRDRFM SSLPLFHAFG LTVGLFTPLM TGSRVFLYPS PLHYRVVPEL 450
VYDRNCTVLF GTSTFLGNYA RFAHPYDFAR VRYVVAGAEK LAESTKQIWQ 500
DKFGIRILEG YGVTECAPVV AINVPMAAKV NTVGRILPGM EARLINVPGI 550
AQGGRLQLRG PNIMRGYLRV ENPGVLEQPS AENAQGELDA NWYDTGDIVT 600
LDEQGFCAIR GRVKRFAKLA GEMVSLESVE QLAISLSPEG QHAAAAKTDS 650
AKGEALVLFT TDSEITRERL IKAARENGVP ELAVPRDIRV VKALPLLGSG 700
KPDFVTLGKM AQDPEMSV 718
Length:718
Mass (Da):79,416
Last modified:April 29, 2008 - v1
Checksum:iA3C7873868B30645
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000950 Genomic DNA. Translation: ACA67328.1.
RefSeqiYP_001719781.1. NC_010465.1.

Genome annotation databases

EnsemblBacteriaiACA67328; ACA67328; YPK_1027.
GeneIDi6089685.
KEGGiypy:YPK_1027.
PATRICi18659194. VBIYerPse127545_1101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000950 Genomic DNA. Translation: ACA67328.1 .
RefSeqi YP_001719781.1. NC_010465.1.

3D structure databases

ProteinModelPortali B1JQC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 502800.YPK_1027.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA67328 ; ACA67328 ; YPK_1027 .
GeneIDi 6089685.
KEGGi ypy:YPK_1027.
PATRICi 18659194. VBIYerPse127545_1101.

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000004907.
KOi K05939.
OMAi ANWVYLE.
OrthoDBi EOG6KHFVG.

Enzyme and pathway databases

BioCyci YPSE502800:GH0W-1037-MONOMER.

Family and domain databases

HAMAPi MF_01162. Aas.
InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR023775. Bifunctional_Aas.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view ]
Pfami PF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view ]
SMARTi SM00563. PlsC. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YPIII.

Entry informationi

Entry nameiAAS_YERPY
AccessioniPrimary (citable) accession number: B1JQC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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