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B1JQC1

- AAS_YERPY

UniProt

B1JQC1 - AAS_YERPY

Protein

Bifunctional protein Aas

Gene

aas

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.UniRule annotation

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.UniRule annotation
    ATP + an acid + [acyl-carrier-protein] = AMP + diphosphate + acyl-[acyl-carrier-protein].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei36 – 361UniRule annotation

    GO - Molecular functioni

    1. acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-KW
    3. long-chain fatty acid [acyl-carrier-protein] ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. fatty acid metabolic process Source: InterPro
    2. phospholipid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Acyltransferase, Ligase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYPSE502800:GH0W-1037-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein AasUniRule annotation
    Including the following 2 domains:
    2-acylglycerophosphoethanolamine acyltransferaseUniRule annotation (EC:2.3.1.40UniRule annotation)
    Alternative name(s):
    2-acyl-GPE acyltransferaseUniRule annotation
    Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferaseUniRule annotation
    Acyl-[acyl-carrier-protein] synthetaseUniRule annotation (EC:6.2.1.20UniRule annotation)
    Alternative name(s):
    Acyl-ACP synthetaseUniRule annotation
    Long-chain-fatty-acid--[acyl-carrier-protein] ligaseUniRule annotation
    Gene namesi
    Name:aasUniRule annotation
    Ordered Locus Names:YPK_1027
    OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
    Taxonomic identifieri502800 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000721: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 718718Bifunctional protein AasPRO_1000137906Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi502800.YPK_1027.

    Structurei

    3D structure databases

    ProteinModelPortaliB1JQC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei258 – 27720HelicalUniRule annotationAdd
    BLAST
    Transmembranei409 – 43325HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni15 – 138124AcyltransferaseAdd
    BLAST
    Regioni233 – 646414AMP-bindingAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.UniRule annotation
    In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000004907.
    KOiK05939.
    OMAiANWVYLE.
    OrthoDBiEOG6KHFVG.

    Family and domain databases

    HAMAPiMF_01162. Aas.
    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR023775. Bifunctional_Aas.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view]
    PfamiPF01553. Acyltransferase. 1 hit.
    PF00501. AMP-binding. 1 hit.
    [Graphical view]
    SMARTiSM00563. PlsC. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1JQC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRLLRALF RGLFRVTIDG VTDQFKHEKL IITPNHVSFL DGALLALFLP    50
    IKPVFAVYTS ITDTWYMRWL KPYVDFVALD PTNPMAIKHL VRMVEQGRPV 100
    VIFPEGRITV TGSLMKIYDG AAFVAAKSGA AVVPIRLDGP EFTHFGRLQG 150
    VLKTRWFPKI SIHVLPATTI PMPQAPRSRE RRVLAGEHLH TIMMAARMAT 200
    VPRETLFEAL LSAQTRYGRF KPCIEDVSFK EDSYQTLLKK TLGVSRILQR 250
    FTVPGEHVGM LLPNATITAA AIFGASLRGR IPALLNYTSG AKGLQSAIIA 300
    ASLKTIVTSR QFLEKGKLTH LPEQVNEVNW VYLEDLKDTV TLTDKLWILF 350
    HLCFPRRAML PQQADDSALI LFTSGSEGNP KGVVHSHASL LANVEQIRTI 400
    ADFTPRDRFM SSLPLFHAFG LTVGLFTPLM TGSRVFLYPS PLHYRVVPEL 450
    VYDRNCTVLF GTSTFLGNYA RFAHPYDFAR VRYVVAGAEK LAESTKQIWQ 500
    DKFGIRILEG YGVTECAPVV AINVPMAAKV NTVGRILPGM EARLINVPGI 550
    AQGGRLQLRG PNIMRGYLRV ENPGVLEQPS AENAQGELDA NWYDTGDIVT 600
    LDEQGFCAIR GRVKRFAKLA GEMVSLESVE QLAISLSPEG QHAAAAKTDS 650
    AKGEALVLFT TDSEITRERL IKAARENGVP ELAVPRDIRV VKALPLLGSG 700
    KPDFVTLGKM AQDPEMSV 718
    Length:718
    Mass (Da):79,416
    Last modified:April 29, 2008 - v1
    Checksum:iA3C7873868B30645
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000950 Genomic DNA. Translation: ACA67328.1.
    RefSeqiYP_001719781.1. NC_010465.1.

    Genome annotation databases

    EnsemblBacteriaiACA67328; ACA67328; YPK_1027.
    GeneIDi6089685.
    KEGGiypy:YPK_1027.
    PATRICi18659194. VBIYerPse127545_1101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000950 Genomic DNA. Translation: ACA67328.1 .
    RefSeqi YP_001719781.1. NC_010465.1.

    3D structure databases

    ProteinModelPortali B1JQC1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 502800.YPK_1027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA67328 ; ACA67328 ; YPK_1027 .
    GeneIDi 6089685.
    KEGGi ypy:YPK_1027.
    PATRICi 18659194. VBIYerPse127545_1101.

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000004907.
    KOi K05939.
    OMAi ANWVYLE.
    OrthoDBi EOG6KHFVG.

    Enzyme and pathway databases

    BioCyci YPSE502800:GH0W-1037-MONOMER.

    Family and domain databases

    HAMAPi MF_01162. Aas.
    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR023775. Bifunctional_Aas.
    IPR002123. Plipid/glycerol_acylTrfase.
    [Graphical view ]
    Pfami PF01553. Acyltransferase. 1 hit.
    PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    SMARTi SM00563. PlsC. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YPIII.

    Entry informationi

    Entry nameiAAS_YERPY
    AccessioniPrimary (citable) accession number: B1JQC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3