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Protein

Bifunctional protein Aas

Gene

aas

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.UniRule annotation

Catalytic activityi

Acyl-[acyl-carrier-protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier-protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.UniRule annotation
ATP + a long-chain fatty acid + an [acyl-carrier-protein] = AMP + diphosphate + a long-chain acyl-[acyl-carrier-protein].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei36 – 361UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Ligase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-1037-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein AasUniRule annotation
Including the following 2 domains:
2-acylglycerophosphoethanolamine acyltransferaseUniRule annotation (EC:2.3.1.40UniRule annotation)
Alternative name(s):
2-acyl-GPE acyltransferaseUniRule annotation
Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferaseUniRule annotation
Acyl-[acyl-carrier-protein] synthetaseUniRule annotation (EC:6.2.1.20UniRule annotation)
Alternative name(s):
Acyl-ACP synthetaseUniRule annotation
Long-chain-fatty-acid--[acyl-carrier-protein] ligaseUniRule annotation
Gene namesi
Name:aasUniRule annotation
Ordered Locus Names:YPK_1027
OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
Taxonomic identifieri502800 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000721 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei258 – 27720HelicalUniRule annotationAdd
BLAST
Transmembranei409 – 43325HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Bifunctional protein AasPRO_1000137906Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB1JQC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 138124AcyltransferaseAdd
BLAST
Regioni233 – 646414AMP-bindingAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.UniRule annotation
In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000004907.
KOiK05939.
OMAiANWVYLE.
OrthoDBiEOG6KHFVG.

Family and domain databases

HAMAPiMF_01162. Aas.
InterProiIPR023775. Aas.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1JQC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRLLRALF RGLFRVTIDG VTDQFKHEKL IITPNHVSFL DGALLALFLP
60 70 80 90 100
IKPVFAVYTS ITDTWYMRWL KPYVDFVALD PTNPMAIKHL VRMVEQGRPV
110 120 130 140 150
VIFPEGRITV TGSLMKIYDG AAFVAAKSGA AVVPIRLDGP EFTHFGRLQG
160 170 180 190 200
VLKTRWFPKI SIHVLPATTI PMPQAPRSRE RRVLAGEHLH TIMMAARMAT
210 220 230 240 250
VPRETLFEAL LSAQTRYGRF KPCIEDVSFK EDSYQTLLKK TLGVSRILQR
260 270 280 290 300
FTVPGEHVGM LLPNATITAA AIFGASLRGR IPALLNYTSG AKGLQSAIIA
310 320 330 340 350
ASLKTIVTSR QFLEKGKLTH LPEQVNEVNW VYLEDLKDTV TLTDKLWILF
360 370 380 390 400
HLCFPRRAML PQQADDSALI LFTSGSEGNP KGVVHSHASL LANVEQIRTI
410 420 430 440 450
ADFTPRDRFM SSLPLFHAFG LTVGLFTPLM TGSRVFLYPS PLHYRVVPEL
460 470 480 490 500
VYDRNCTVLF GTSTFLGNYA RFAHPYDFAR VRYVVAGAEK LAESTKQIWQ
510 520 530 540 550
DKFGIRILEG YGVTECAPVV AINVPMAAKV NTVGRILPGM EARLINVPGI
560 570 580 590 600
AQGGRLQLRG PNIMRGYLRV ENPGVLEQPS AENAQGELDA NWYDTGDIVT
610 620 630 640 650
LDEQGFCAIR GRVKRFAKLA GEMVSLESVE QLAISLSPEG QHAAAAKTDS
660 670 680 690 700
AKGEALVLFT TDSEITRERL IKAARENGVP ELAVPRDIRV VKALPLLGSG
710
KPDFVTLGKM AQDPEMSV
Length:718
Mass (Da):79,416
Last modified:April 29, 2008 - v1
Checksum:iA3C7873868B30645
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA67328.1.
RefSeqiWP_011192876.1. NZ_CP009792.1.

Genome annotation databases

EnsemblBacteriaiACA67328; ACA67328; YPK_1027.
KEGGiypy:YPK_1027.
PATRICi18659194. VBIYerPse127545_1101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA67328.1.
RefSeqiWP_011192876.1. NZ_CP009792.1.

3D structure databases

ProteinModelPortaliB1JQC1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA67328; ACA67328; YPK_1027.
KEGGiypy:YPK_1027.
PATRICi18659194. VBIYerPse127545_1101.

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000004907.
KOiK05939.
OMAiANWVYLE.
OrthoDBiEOG6KHFVG.

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-1037-MONOMER.

Family and domain databases

HAMAPiMF_01162. Aas.
InterProiIPR023775. Aas.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PfamiPF01553. Acyltransferase. 1 hit.
PF00501. AMP-binding. 1 hit.
[Graphical view]
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YPIII.

Entry informationi

Entry nameiAAS_YERPY
AccessioniPrimary (citable) accession number: B1JQC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: July 22, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.