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B1JQ12 (GPPA_YERPY) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:YPK_4037
OrganismYersinia pseudotuberculosis serotype O:3 (strain YPIII) [Complete proteome] [HAMAP]
Taxonomic identifier502800 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000192544

Sequences

Sequence LengthMass (Da)Tools
B1JQ12 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 583A72F958AFFEB5

FASTA49855,926
        10         20         30         40         50         60 
MMLSSTSLYA AIDLGSNSFH MLVVREVAGS IQTLARIKRK VRLAAGLDNQ NHLSQEAMER 

        70         80         90        100        110        120 
GWQCLKLFSE RLQDIPLDQI RVVATATLRL ASNADEFLRT ATEILGCPIQ VISGEEEARL 

       130        140        150        160        170        180 
IYHGVAHTTG GPEQRLVVDI GGGSTELVTG NGAQANILVS LSMGCVTWLE RYFGDRHLAK 

       190        200        210        220        230        240 
ENFERAELAA HEMIKPVAQR FREHGWQVCV GASGTVQALQ EIMVAQGMDE LITLAKLQQL 

       250        260        270        280        290        300 
KQRAIQCGKL EELEIPGLTL ERALVFPSGL SILIAIFQEL SIESMTLAGG ALREGLVYGM 

       310        320        330        340        350        360 
LHLPVEQDIR RRTLRNLQRR YLLDTEQAKR VSCLADNFFL QVEKEWHLDG RCREFLQNAC 

       370        380        390        400        410        420 
LIHEIGLSVD FKHAPQHAAY LIRNLDLPGF TPAQKLLLSA LLQNQSDTID LSLLNQQNAL 

       430        440        450        460        470        480 
PADMAQHLCR LLRLAIIFSS RRRDDTLPAV RLRADNNALY VLVPQGWLEQ HPYRAEALEQ 

       490 
ESHWQSYVQW PLLLEELS 

« Hide

References

[1]"Complete sequence of Yersinia pseudotuberculosis YPIII."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YPIII.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000950 Genomic DNA. Translation: ACA70299.1.
RefSeqYP_001722752.1. NC_010465.1.

3D structure databases

ProteinModelPortalB1JQ12.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING502800.YPK_4037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA70299; ACA70299; YPK_4037.
GeneID6090284.
KEGGypy:YPK_4037.
PATRIC18665853. VBIYerPse127545_4362.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMASYVHWAL.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycYPSE502800:GH0W-4096-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPPA_YERPY
AccessionPrimary (citable) accession number: B1JQ12
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways