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B1JNS8

- GCSP_YERPY

UniProt

B1JNS8 - GCSP_YERPY

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciYPSE502800:GH0W-878-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:YPK_0869
    OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
    Taxonomic identifieri502800 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000721: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 959959Glycine dehydrogenase (decarboxylating)PRO_1000132464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi502800.YPK_0869.

    Structurei

    3D structure databases

    ProteinModelPortaliB1JNS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1JNS8-1 [UniParc]FASTAAdd to Basket

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    MTQNLSQLEH NDAFIQRHIG SSVEQQQQML AAVGASSLST LIQQIVPADI    50
    QLPGPPPVGE AATEHQALAE LKGIASQNQC YKSYIGMGYS PVLTPPVILR 100
    NMLENPGWYT AYTPYQPEVS QGRLEALLNF QQLTQDLTGL DLASASLLDE 150
    ATAAAESMAL AKRASKLKDA NRFFVADDVH PQTLDVVLTR AETFGFDVIV 200
    DRAEKVLELD GIFGVLLQQV GTTGELHDYS ALLAELKKRK IITSVAADIM 250
    ALVLLTAPGA QGADVVFGSA QRFGVPMGYG GPHAAFFACR DEFKRSMPGR 300
    IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIASLYAV 350
    YHGPQGLQRI AGRIHRMTDI LAAGLQHAGL TLRFKHWFDT LTVEVKDKAA 400
    VLARALSFGI NLRTDIHGAV GITLNETTSR EDIQTLFALF VGDNHGLDID 450
    QLDAAVSQHS QSIQDSMLRR DPILTHPVFN RYHSETEMMR YMHRLERKDL 500
    ALNQAMIPLG SCTMKLNAAA EMIPITWPEF AELHPFCPPE QAAGYQQMIG 550
    QLSQWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NQANRHICLI 600
    PSSAHGTNPA SAQMAGMSVV VVACDKQGNI DLHDLRQKAE HAGDELSCIM 650
    VTYPSTHGVY EETIREVCQI VHQFGGQVYL DGANMNAQVG ITTPGYIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV QIDGMTTQQG 750
    AVSAAPFGSA SILPISWMYI RMMGADGLKQ ASQVAILNAN YIATRLKNAY 800
    PVLYTGHDGR VAHECILDIR PLKEATGISE MDIAKRLIDF GFHAPTMSFP 850
    VAGTLMVEPT ESESKVELDR FIDAMLAIRA EIEKVAQGEW PLEDNPLVNA 900
    PHTQAELVGE WTHPYSRELA VFPVAGVLEN KYWPTVKRLD DVYGDRNLFC 950
    SCVPISDYE 959
    Length:959
    Mass (Da):104,737
    Last modified:April 29, 2008 - v1
    Checksum:iBDD898DA71EF98A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000950 Genomic DNA. Translation: ACA67170.1.
    RefSeqiYP_001719623.1. NC_010465.1.

    Genome annotation databases

    EnsemblBacteriaiACA67170; ACA67170; YPK_0869.
    GeneIDi6090419.
    KEGGiypy:YPK_0869.
    PATRICi18658850. VBIYerPse127545_0930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000950 Genomic DNA. Translation: ACA67170.1 .
    RefSeqi YP_001719623.1. NC_010465.1.

    3D structure databases

    ProteinModelPortali B1JNS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 502800.YPK_0869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA67170 ; ACA67170 ; YPK_0869 .
    GeneIDi 6090419.
    KEGGi ypy:YPK_0869.
    PATRICi 18658850. VBIYerPse127545_0930.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci YPSE502800:GH0W-878-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YPIII.

    Entry informationi

    Entry nameiGCSP_YERPY
    AccessioniPrimary (citable) accession number: B1JNS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3