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B1JMD1 (ASTD_YERPY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:YPK_2227
OrganismYersinia pseudotuberculosis serotype O:3 (strain YPIII) [Complete proteome] [HAMAP]
Taxonomic identifier502800 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_1000138067

Regions

Nucleotide binding234 – 2396NAD By similarity

Sites

Active site2571 By similarity
Active site2911 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1JMD1 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 989EEAA284781632

FASTA50554,765
        10         20         30         40         50         60 
MSQHVMFNAV LSSHPALFIQ GEWRIGNGVS FEKQDPMSQQ RLWQARAADH TDVTLACHAA 

        70         80         90        100        110        120 
RAAFPAWARA SLEQRATVIQ QFAALLEQHK QSLARTISLE TSKPYWETLT EVQAMIGKVA 

       130        140        150        160        170        180 
ISLQAYQTRT GHSQTPMGDS MSVLRHRPHG VLAVFGPYNF PGHLPNGHIV PALLAGNTVV 

       190        200        210        220        230        240 
FKPSELTPWT AEETVKLWQQ AGIPDGVLNL VQGGRETGEA LAAQPDIDGL LFTGSAHTGY 

       250        260        270        280        290        300 
HLHRQLAGQP EKMLALEMGG NNALIVEQVK DRDAVVNLAI QSAFISAGQR CTCSRRLLVK 

       310        320        330        340        350        360 
TGAEGDAFLL RFTAVAQALR IGRWDEQPAP FMGAVISSQA AERMLAAQQH LLLLGGESLL 

       370        380        390        400        410        420 
NMTRPDSQSA LLTPGIIDIT NISEVPDEEY FGPLVSVIRY TDFTEALKIA NQTRFGLAVG 

       430        440        450        460        470        480 
LVSEDRQQFE QLLLEARAGI VNWNKPLTGA SSAAPFGGVG ASGNHRPSAF YAADYCAWPM 

       490        500 
ASLECEHLTL PATLSPGISF DLPKV

« Hide

References

[1]"Complete sequence of Yersinia pseudotuberculosis YPIII."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YPIII.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000950 Genomic DNA. Translation: ACA68508.1.
RefSeqYP_001720961.1. NC_010465.1.

3D structure databases

ProteinModelPortalB1JMD1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB1JMD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6089059.
GenomeReviewsGene locus YPK_2227 in contig CP000950_GR.
KEGGypy:YPK_2227.
PATRIC18661839. VBIYerPse127545_2405.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMAMTQRDPR.
ProtClustDBPRK09457.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_YERPY
AccessionPrimary (citable) accession number: B1JMD1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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