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B1JM21

- UPPP_YERPY

UniProt

B1JM21 - UPPP_YERPY

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-649-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:YPK_0640
OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
Taxonomic identifieri502800 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000721: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalUniRule annotationAdd
BLAST
Transmembranei45 – 6521HelicalUniRule annotationAdd
BLAST
Transmembranei88 – 10821HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei153 – 17220HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 20921HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24121HelicalUniRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Undecaprenyl-diphosphatasePRO_1000197423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi502800.YPK_0640.

Structurei

3D structure databases

ProteinModelPortaliB1JM21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiMEIGTIF.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B1JM21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDMYSLFVA FILGVVEGLT EFLPVSSTGH MIIVGELLGF TGDKAKTFEV
60 70 80 90 100
IIQLGSILAV VVVFWRRLFG LIGIHFGAVP HEGKTNGHLT LGHILLAMIP
110 120 130 140 150
AVILGLAFHD VIKALFDPKS VMYALVAGGV LLLAAEWLKP KNPKAVGLDD
160 170 180 190 200
ITYRQAFAIG CFQCLALWPG FSRSGATISG GMLVGVNRYA ASEFSFILAV
210 220 230 240 250
PMMIGASGLD LYKSLHFLTL GDLPMFAVGF ITAFIVALIA IKTFLSLIKR
260 270
ISFVPFAIYR FIVAAVVYWV FM
Length:272
Mass (Da):29,483
Last modified:April 29, 2008 - v1
Checksum:i164FC644788F2189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA66943.1.
RefSeqiYP_001719396.1. NC_010465.1.

Genome annotation databases

EnsemblBacteriaiACA66943; ACA66943; YPK_0640.
GeneIDi6090979.
KEGGiypy:YPK_0640.
PATRICi18658352. VBIYerPse127545_0681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA66943.1 .
RefSeqi YP_001719396.1. NC_010465.1.

3D structure databases

ProteinModelPortali B1JM21.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 502800.YPK_0640.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA66943 ; ACA66943 ; YPK_0640 .
GeneIDi 6090979.
KEGGi ypy:YPK_0640.
PATRICi 18658352. VBIYerPse127545_0681.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi MEIGTIF.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci YPSE502800:GH0W-649-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YPIII.

Entry informationi

Entry nameiUPPP_YERPY
AccessioniPrimary (citable) accession number: B1JM21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3