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B1JL36

- TYPH_YERPY

UniProt

B1JL36 - TYPH_YERPY

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciYPSE502800:GH0W-3671-MONOMER.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Name:deoAUniRule annotation
    Ordered Locus Names:YPK_3626
    OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
    Taxonomic identifieri502800 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
    ProteomesiUP000000721: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 440440Thymidine phosphorylasePRO_1000186278Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi502800.YPK_3626.

    Structurei

    3D structure databases

    ProteinModelPortaliB1JL36.
    SMRiB1JL36. Positions 1-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000047313.
    KOiK00758.
    OMAiFINGVRD.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_01628. Thymid_phosp.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1JL36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLAQEIIRK KRDGQPLSEE EIRFFINGIR DNVVSEGQIA ALAMTIYFHD    50
    MSMPERVALT MAMRDSGTVL NWKSLNLNGP LVDKHSTGGV GDVTSLMLGP 100
    MVAACGGYVP MISGRGLGHT GGTLDKLEAI PGFDIFPDDN AFRKIIQNVG 150
    VAIIGQTSSL APADKRFYAT RDITATVDSI PLITASILAK KLAEGLDALV 200
    MDVKVGSGAF MPTYSLSADL AQAIVGVANG AGCKTTALLT DMNQVLASSA 250
    GNGVEVREAV RFLTGEYRNP RLLEVTMALC VEMLLSGGLA HDEADARAKL 300
    QAVLDNGKAA EVFGRMVAAQ KGPVDFVERY DSYLPVATLS KPVFAEQTGI 350
    ITAMDTRALG MAVVALGGGR RRATDPIDYS VGLTEMARLG TRVDGQQPLA 400
    VIHANNEDDW QQAAEAVRAA ITLGNNAPEE TPVIYRRITE 440
    Length:440
    Mass (Da):46,887
    Last modified:April 29, 2008 - v1
    Checksum:iE5934E2858B1EFF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000950 Genomic DNA. Translation: ACA69893.1.
    RefSeqiWP_011191687.1. NC_010465.1.
    YP_001722346.1. NC_010465.1.

    Genome annotation databases

    EnsemblBacteriaiACA69893; ACA69893; YPK_3626.
    GeneIDi6089127.
    KEGGiypy:YPK_3626.
    PATRICi18664941. VBIYerPse127545_3924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000950 Genomic DNA. Translation: ACA69893.1 .
    RefSeqi WP_011191687.1. NC_010465.1.
    YP_001722346.1. NC_010465.1.

    3D structure databases

    ProteinModelPortali B1JL36.
    SMRi B1JL36. Positions 1-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 502800.YPK_3626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA69893 ; ACA69893 ; YPK_3626 .
    GeneIDi 6089127.
    KEGGi ypy:YPK_3626.
    PATRICi 18664941. VBIYerPse127545_3924.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000047313.
    KOi K00758.
    OMAi FINGVRD.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    BioCyci YPSE502800:GH0W-3671-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_01628. Thymid_phosp.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: YPIII.

    Entry informationi

    Entry nameiTYPH_YERPY
    AccessioniPrimary (citable) accession number: B1JL36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3