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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei224 – 2241UniRule annotation
Active sitei226 – 2261UniRule annotation
Active sitei231 – 2311UniRule annotation
Active sitei404 – 4041UniRule annotation
Active sitei406 – 4061UniRule annotation
Active sitei411 – 4111UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-2083-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:YPK_2063
OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
Taxonomic identifieri502800 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000721 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Cardiolipin synthase APRO_1000098922Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini219 – 24628PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini399 – 42628PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077403.
KOiK06131.
OMAiFFKQDSG.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1JKT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTFYTVISW LSVFGYWLLI AGVTLRILMK RRAVPSAMAW LLIIYILPLV
60 70 80 90 100
GIIAYLSFGE LHLGKRRAER AKAMWPSTAR WLSELKECQH IFANSNSEVA
110 120 130 140 150
SPLFQLCERR QGINGVKGNQ LQLLTTTDDT LKALVRDIEL ARHNIEMVFY
160 170 180 190 200
IWQPGGLVDQ VAESLMAAAR RGVHCRLLLD SAGSKQFFRS PYPAMMRNAG
210 220 230 240 250
IEVVEALKVN VFRMFLRRMD LRQHRKIVLI DNYVAYTGSM NMVDPRFFKQ
260 270 280 290 300
DAGVGQWIDM MARMEGPVAT TLGIVYACDW EIETGKRILP PPPDANIMPF
310 320 330 340 350
EEETGHTIQV IASGPGFPEE MIHQALLTAV YAAREQLIMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIIVPR ENDSMMVRWA SRAFFTELLN AGVKIYQFEG
410 420 430 440 450
GLLHSKSVLV DGQLSLVGTV NLDMRSLWLN FEITLVIDDD GFGADLAQVQ
460 470 480
DDYIARSALL DGELWNKRPL WHRVTERLFY FFSPLL
Length:486
Mass (Da):55,084
Last modified:April 29, 2008 - v1
Checksum:iB50C78CD00A2C32E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA68350.1.
RefSeqiWP_012304089.1. NZ_CP009792.1.

Genome annotation databases

EnsemblBacteriaiACA68350; ACA68350; YPK_2063.
KEGGiypy:YPK_2063.
PATRICi18661484. VBIYerPse127545_2230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA68350.1.
RefSeqiWP_012304089.1. NZ_CP009792.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACA68350; ACA68350; YPK_2063.
KEGGiypy:YPK_2063.
PATRICi18661484. VBIYerPse127545_2230.

Phylogenomic databases

HOGENOMiHOG000077403.
KOiK06131.
OMAiFFKQDSG.

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-2083-MONOMER.

Family and domain databases

HAMAPiMF_00190. Cardiolipin_synth_ClsA. 1 hit.
InterProiIPR022924. Cardiolipin_synthase.
IPR030840. CL_synthase_A.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLSA_YERPY
AccessioniPrimary (citable) accession number: B1JKT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.