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B1JGL9

- NUOH_YERPY

UniProt

B1JGL9 - NUOH_YERPY

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Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
  2. quinone binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, Ubiquinone

Enzyme and pathway databases

BioCyciYPSE502800:GH0W-1586-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit HUniRule annotation
NDH-1 subunit HUniRule annotation
Gene namesi
Name:nuoHUniRule annotation
Ordered Locus Names:YPK_1566
OrganismiYersinia pseudotuberculosis serotype O:3 (strain YPIII)
Taxonomic identifieri502800 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000000721: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei81 – 10121HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei154 – 17421HelicalUniRule annotationAdd
BLAST
Transmembranei186 – 20621HelicalUniRule annotationAdd
BLAST
Transmembranei237 – 25721HelicalUniRule annotationAdd
BLAST
Transmembranei265 – 28521HelicalUniRule annotationAdd
BLAST
Transmembranei304 – 32421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325NADH-quinone oxidoreductase subunit HPRO_1000143628Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi502800.YPK_1566.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1005.
HOGENOMiHOG000228276.
KOiK00337.
OMAiGWYPPLE.
OrthoDBiEOG6B62B4.

Family and domain databases

HAMAPiMF_01350. NDH1_NuoH.
InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERiPTHR11432. PTHR11432. 1 hit.
PfamiPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEiPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1JGL9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWFTPELIE ILISVLKAVV ILLVVVTCGA FMSFGERRLL GLFQNRYGPN
60 70 80 90 100
RVGWGGSLQL VADMIKMFFK EDWVPRFSDR AIFTLAPVIA FTSLLLSFAI
110 120 130 140 150
VPVSPTWAVA DLNIGILFFL MMAGLAVYAV LFAGWASNNK YSLLGAMRAS
160 170 180 190 200
AQTLSYEVFL GLSLMGVVAQ VGSFNMQDIV NSQEHVWNVI PQFFGFLTFA
210 220 230 240 250
IAGVAVCHRH PFDQPEAEQE LADGYHIEYS GMKFGLFFVG EYIGIVTVSA
260 270 280 290 300
LIVTLFFGGW QGPFLPPFIW FALKTAFFMV MFILIRASLP RPRYDQVMSF
310 320
GWKVCLPLTL LNLLATAAVI LYNAQ
Length:325
Mass (Da):36,213
Last modified:April 29, 2008 - v1
Checksum:i53FE4B56D845C0DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA67859.1.
RefSeqiWP_012303932.1. NC_010465.1.
YP_001720312.1. NC_010465.1.

Genome annotation databases

EnsemblBacteriaiACA67859; ACA67859; YPK_1566.
GeneIDi6091217.
KEGGiypy:YPK_1566.
PATRICi18660382. VBIYerPse127545_1680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000950 Genomic DNA. Translation: ACA67859.1 .
RefSeqi WP_012303932.1. NC_010465.1.
YP_001720312.1. NC_010465.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 502800.YPK_1566.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA67859 ; ACA67859 ; YPK_1566 .
GeneIDi 6091217.
KEGGi ypy:YPK_1566.
PATRICi 18660382. VBIYerPse127545_1680.

Phylogenomic databases

eggNOGi COG1005.
HOGENOMi HOG000228276.
KOi K00337.
OMAi GWYPPLE.
OrthoDBi EOG6B62B4.

Enzyme and pathway databases

BioCyci YPSE502800:GH0W-1586-MONOMER.

Family and domain databases

HAMAPi MF_01350. NDH1_NuoH.
InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view ]
PANTHERi PTHR11432. PTHR11432. 1 hit.
Pfami PF00146. NADHdh. 1 hit.
[Graphical view ]
PROSITEi PS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: YPIII.

Entry informationi

Entry nameiNUOH_YERPY
AccessioniPrimary (citable) accession number: B1JGL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3