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B1JGL9 (NUOH_YERPY) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit H

EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit H
NDH-1 subunit H
Gene names
Name:nuoH
Ordered Locus Names:YPK_1566
OrganismYersinia pseudotuberculosis serotype O:3 (strain YPIII) [Complete proteome] [HAMAP]
Taxonomic identifier502800 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone By similarity. HAMAP-Rule MF_01350

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP-Rule MF_01350

Subunit structure

NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_01350.

Sequence similarities

Belongs to the complex I subunit 1 family.

Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325NADH-quinone oxidoreductase subunit H HAMAP-Rule MF_01350
PRO_1000143628

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane237 – 25721Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane304 – 32421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B1JGL9 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 53FE4B56D845C0DD

FASTA32536,213
        10         20         30         40         50         60 
MSWFTPELIE ILISVLKAVV ILLVVVTCGA FMSFGERRLL GLFQNRYGPN RVGWGGSLQL 

        70         80         90        100        110        120 
VADMIKMFFK EDWVPRFSDR AIFTLAPVIA FTSLLLSFAI VPVSPTWAVA DLNIGILFFL 

       130        140        150        160        170        180 
MMAGLAVYAV LFAGWASNNK YSLLGAMRAS AQTLSYEVFL GLSLMGVVAQ VGSFNMQDIV 

       190        200        210        220        230        240 
NSQEHVWNVI PQFFGFLTFA IAGVAVCHRH PFDQPEAEQE LADGYHIEYS GMKFGLFFVG 

       250        260        270        280        290        300 
EYIGIVTVSA LIVTLFFGGW QGPFLPPFIW FALKTAFFMV MFILIRASLP RPRYDQVMSF 

       310        320 
GWKVCLPLTL LNLLATAAVI LYNAQ 

« Hide

References

[1]"Complete sequence of Yersinia pseudotuberculosis YPIII."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Challacombe J.F., Green L., Lindler L.E., Nikolich M.P., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YPIII.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000950 Genomic DNA. Translation: ACA67859.1.
RefSeqYP_001720312.1. NC_010465.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING502800.YPK_1566.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA67859; ACA67859; YPK_1566.
GeneID6091217.
KEGGypy:YPK_1566.
PATRIC18660382. VBIYerPse127545_1680.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1005.
HOGENOMHOG000228276.
KOK00337.
OMALDLGWKF.
OrthoDBEOG6B62B4.
ProtClustDBPRK06076.

Enzyme and pathway databases

BioCycYPSE502800:GH0W-1586-MONOMER.

Family and domain databases

HAMAPMF_01350. NDH1_NuoH.
InterProIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
IPR018086. NADH_UbQ_OxRdtase_su1_CS.
[Graphical view]
PANTHERPTHR11432. PTHR11432. 1 hit.
PfamPF00146. NADHdh. 1 hit.
[Graphical view]
PROSITEPS00667. COMPLEX1_ND1_1. 1 hit.
PS00668. COMPLEX1_ND1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOH_YERPY
AccessionPrimary (citable) accession number: B1JGL9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families