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B1JFN3 (GCH4_PSEPW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PputW619_5141
OrganismPseudomonas putida (strain W619) [Complete proteome] [HAMAP]
Taxonomic identifier390235 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000372034

Sites

Site1491May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
B1JFN3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: E37B1B66BC21746C

FASTA29532,440
        10         20         30         40         50         60 
MTSLTLPDIA AQKHQHATPL AWVGMCGIAL PVHFDGRSVA AMADAGVSLE DGSSRGIHMS 

        70         80         90        100        110        120 
RLYLSLERLE RQSLTPLAIR QILADFLASH EGLSHAAYLR LTFDHLLKRP ALVSPLAGWK 

       130        140        150        160        170        180 
SYSITVDAKI ENGMFHVELS VRVPYSSTCP CSAALARQLI QQQFQADFSG QAINREAVLE 

       190        200        210        220        230        240 
WLGSSHGIVA TPHSQRSLAE VNVRLGDRLE VLPVTELIDR IEASLGTAVQ TAVKRADEQA 

       250        260        270        280        290 
FALANGQNLM FCEDAARRLH QALQQMDWAK AFKLRVEHAE SLHAHDAVAA SQWQW 

« Hide

References

[1]"Complete sequence of Pseudomonas putida W619."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Taghavi S., Vangronsveld D., van der Lelie D., Richardson P.
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: W619.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000949 Genomic DNA. Translation: ACA75617.1.
RefSeqYP_001751986.1. NC_010501.1.

3D structure databases

ProteinModelPortalB1JFN3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING390235.PputW619_5141.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACA75617; ACA75617; PputW619_5141.
GeneID6114143.
KEGGppw:PputW619_5141.
PATRIC19960264. VBIPsePut93764_5176.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMAFCEDAAR.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycPPUT390235:GHHJ-5236-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_PSEPW
AccessionPrimary (citable) accession number: B1JFN3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways