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B1JFN3

- GCH4_PSEPW

UniProt

B1JFN3 - GCH4_PSEPW

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudomonas putida (strain W619)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPPUT390235:GHHJ-5236-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:PputW619_5141
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000720: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295GTP cyclohydrolase FolE2PRO_0000372034Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390235.PputW619_5141.

Structurei

3D structure databases

ProteinModelPortaliB1JFN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiWISLIER.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1JFN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSLTLPDIA AQKHQHATPL AWVGMCGIAL PVHFDGRSVA AMADAGVSLE
60 70 80 90 100
DGSSRGIHMS RLYLSLERLE RQSLTPLAIR QILADFLASH EGLSHAAYLR
110 120 130 140 150
LTFDHLLKRP ALVSPLAGWK SYSITVDAKI ENGMFHVELS VRVPYSSTCP
160 170 180 190 200
CSAALARQLI QQQFQADFSG QAINREAVLE WLGSSHGIVA TPHSQRSLAE
210 220 230 240 250
VNVRLGDRLE VLPVTELIDR IEASLGTAVQ TAVKRADEQA FALANGQNLM
260 270 280 290
FCEDAARRLH QALQQMDWAK AFKLRVEHAE SLHAHDAVAA SQWQW
Length:295
Mass (Da):32,440
Last modified:April 29, 2008 - v1
Checksum:iE37B1B66BC21746C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000949 Genomic DNA. Translation: ACA75617.1.
RefSeqiWP_012316893.1. NC_010501.1.
YP_001751986.1. NC_010501.1.

Genome annotation databases

EnsemblBacteriaiACA75617; ACA75617; PputW619_5141.
GeneIDi6114143.
KEGGippw:PputW619_5141.
PATRICi19960264. VBIPsePut93764_5176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000949 Genomic DNA. Translation: ACA75617.1 .
RefSeqi WP_012316893.1. NC_010501.1.
YP_001751986.1. NC_010501.1.

3D structure databases

ProteinModelPortali B1JFN3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390235.PputW619_5141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA75617 ; ACA75617 ; PputW619_5141 .
GeneIDi 6114143.
KEGGi ppw:PputW619_5141.
PATRICi 19960264. VBIPsePut93764_5176.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi WISLIER.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci PPUT390235:GHHJ-5236-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W619.

Entry informationi

Entry nameiGCH4_PSEPW
AccessioniPrimary (citable) accession number: B1JFN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3