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B1JBP7

- LPXB_PSEPW

UniProt

B1JBP7 - LPXB_PSEPW

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, PputW619_4069
Organism
Pseudomonas putida (strain W619)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPPUT390235:GHHJ-4131-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PputW619_4069
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000000720: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Lipid-A-disaccharide synthaseUniRule annotationPRO_1000123056Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390235.PputW619_4069.

Structurei

3D structure databases

ProteinModelPortaliB1JBP7.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018004.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B1JBP7-1 [UniParc]FASTAAdd to Basket

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MAQLCVALVA GEASGDILGS GLMRALKARH PQVRFIGVGG PLMEAEGMQS    50
YFPMERLAVM GLVEVLGRLR ELLKRRKALI QTLIAEKPDV FIGIDAPDFT 100
LNIELKLRQA GIKTVHYVSP SVWAWRQKRV LKIREGCDLM LTLLPFEARF 150
YEEQGVPVRF VGHPLADTIP LAADRQAARM ALGLDAGPVV ALMPGSRGGE 200
VGRLGALFLD AAQRLVELIP GVHFVLPCAN GARRAQLEQM LEGRELPLTL 250
LDGQSHQALA ACDAVLIASG TATLEAMLYK RPMVVAYRLA PLTYWILKRL 300
VKSPYVSLPN LLAQRELVPE LLQDAATSEA LAQTLAPLVA DGRQQTERFD 350
EIHRTLRRDA SNQAADAVLA LLKDR 375
Length:375
Mass (Da):41,081
Last modified:April 29, 2008 - v1
Checksum:i9DB0EF47607E20E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000949 Genomic DNA. Translation: ACA74549.1.
RefSeqiWP_012315889.1. NC_010501.1.
YP_001750918.1. NC_010501.1.

Genome annotation databases

EnsemblBacteriaiACA74549; ACA74549; PputW619_4069.
GeneIDi6113038.
KEGGippw:PputW619_4069.
PATRICi19958029. VBIPsePut93764_4092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000949 Genomic DNA. Translation: ACA74549.1 .
RefSeqi WP_012315889.1. NC_010501.1.
YP_001750918.1. NC_010501.1.

3D structure databases

ProteinModelPortali B1JBP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390235.PputW619_4069.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACA74549 ; ACA74549 ; PputW619_4069 .
GeneIDi 6113038.
KEGGi ppw:PputW619_4069.
PATRICi 19958029. VBIPsePut93764_4092.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018004.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PPUT390235:GHHJ-4131-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: W619.

Entry informationi

Entry nameiLPXB_PSEPW
AccessioniPrimary (citable) accession number: B1JBP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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