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Protein

Catalase-peroxidase

Gene

katG

Organism
Pseudomonas putida (strain W619)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei88Transition state stabilizerUniRule annotation1
Active sitei92Proton acceptorUniRule annotation1
Metal bindingi286Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciPPUT390235:G1GBA-2298-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:PputW619_2235
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548691 – 752Catalase-peroxidaseAdd BLAST752

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91 ↔ 245Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-271)UniRule annotation
Cross-linki245 ↔ 271Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB1J7Q1

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi390235.PputW619_2235

Structurei

3D structure databases

ProteinModelPortaliB1J7Q1
SMRiB1J7Q1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X Bacteria
COG0376 LUCA
HOGENOMiHOG000218110
KOiK03782
OMAiPEEDIYW
OrthoDBiPOG091H05R1

Family and domain databases

HAMAPiMF_01961 Catal_peroxid, 1 hit
InterProiView protein in InterPro
IPR000763 Catalase_peroxidase
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PANTHERiPTHR30555 PTHR30555, 1 hit
PfamiView protein in Pfam
PF00141 peroxidase, 2 hits
PRINTSiPR00460 BPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 3 hits
TIGRFAMsiTIGR00198 cat_per_HPI, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B1J7Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNESKCPFH QTAGGGTTNR DWWPDQLNLR ILHQHGTKSD PMDPDFDYAK
60 70 80 90 100
AFKSLDFQAL KQDLTALMTD SQDWWPADFG HYGPLFIRMA WHSAGTYRIG
110 120 130 140 150
DGRGGAGSGQ QRFAPLNSWP DNVSLDKARR LLWPIKQKYG NKISWADLIV
160 170 180 190 200
LTGNVALESM GFKTFGFSGG RADVWEPDED VYWGSEKVWL GGDTRYGKDQ
210 220 230 240 250
VKAQAPGQGD LVAEPAKHGE EQNRDLSAER NLENPLAAVQ MGLIYVNPEG
260 270 280 290 300
PEGNPDPVAS GKDIRETFGR MAMNDEETVA LIAGGHAFGK THGAGPADNV
310 320 330 340 350
GAEPEAAGLE LQGLGWANKF GTGKGGDTIT SGLEVTWTST PTQWSNEYLN
360 370 380 390 400
NLFNFEWELT KSPAGAHQWQ PKEGKGAGTV PDAHDPSKRH APSMLTSDLA
410 420 430 440 450
LRFDPIYEPI ARRFKDNPDQ LADAFARAWY KLIHRDMGPL ARYLGPEMPN
460 470 480 490 500
EELLWQDPLP KADQPLPSEQ DIAALKTKVL ASGLSVGELV STAWAAASTF
510 520 530 540 550
RGSDKRGGAN GARLRLAPQK DWPANQGTGK VLAALEQIQG EFNNGGKHIS
560 570 580 590 600
LADLIVLAGT AAVEKAAKDA GYAGNVQFRP GRVDASQEQT DVESFAVLEP
610 620 630 640 650
LADGFRNFTK ARYSVKAEKL LLDKAQLLTL TAPELTVLIG GLRVLGANHG
660 670 680 690 700
GSKHGVFTDQ PGTLSNDFFR NLLDMGVEWK ATSGDNESFE GRDRKTGQVK
710 720 730 740 750
WTGTRVDLVF GSHAQLRALS EVYGSSDGKD KFVKDFVAAW VKVMELDRFD

LK
Length:752
Mass (Da):82,105
Last modified:April 29, 2008 - v1
Checksum:i84F29A6453CE4D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA Translation: ACA72735.1
RefSeqiWP_012314124.1, NC_010501.1

Genome annotation databases

EnsemblBacteriaiACA72735; ACA72735; PputW619_2235
KEGGippw:PputW619_2235

Similar proteinsi

Entry informationi

Entry nameiKATG_PSEPW
AccessioniPrimary (citable) accession number: B1J7Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 29, 2008
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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