B1J6Z2 (B1J6Z2_PSEPW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 2 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I 2 HAMAP MF_00223

Gene names

Name:	folE2 HAMAP MF_00223
Ordered Locus Names:	PputW619_2021

Organism

Pseudomonas putida (strain W619) [Complete proteome] [HAMAP] EMBL ACA72521.1

Taxonomic identifier

390235 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 Nucleotide-binding Zinc HAMAP MF_00223
Molecular function	Hydrolase HAMAP MF_00223 EMBL ACA72521.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	75	1	Zinc By similarity HAMAP MF_00223
	Metal binding	78	1	Zinc By similarity HAMAP MF_00223
	Metal binding	146	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	B1J6Z2 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 2D02ABD28B385D2D	FASTA	186	20,909
	10 20 30 40 50 60 MSHSLAEHYH EILVGVGENP QREGLLETPK RAAKAMQYLC NGYGQNLQEV VNGALFESQN 70 80 90 100 110 120 DEMIVVRDIE LYSLCEHHML PFIGKAHVAY LPTGRVLGLS KVARVVDMFA RRLQIQENLT 130 140 150 160 170 180 RQIAYAIQEV TDAAGVAVVI EAKHMCMMMR GVEKQNSVMI SSVMLGEFRD SASTRHEFLN LIGRHN

References

[1]

"Complete sequence of Pseudomonas putida W619." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Taghavi S., Vangronsveld D., van der Lelie D., Richardson P. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000949 Genomic DNA. Translation: ACA72521.1.
RefSeq	YP_001748890.1. NC_010501.1.
3D structure databases
ProteinModelPortal	B1J6Z2.
SMR	B1J6Z2. Positions 11-180.
ModBase	Search...
Protein-protein interaction databases
STRING	B1J6Z2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6110974.
GenomeReviews	Gene locus PputW619_2021 in contig CP000949_GR.
KEGG	ppw:PputW619_2021.
PATRIC	19953888. VBIPsePut93764_2041.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG370191.
OMA	HEEMIIV.
ProtClustDB	PRK12606.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1J6Z2_PSEPW

Accession

Primary (citable) accession number: B1J6Z2

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)