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Protein

Acetaldehyde dehydrogenase 1

Gene

PputW619_1983

Organism
Pseudomonas putida (strain W619)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei132Acyl-thioester intermediateUniRule annotation1
Binding sitei287NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 15NADUniRule annotation4
Nucleotide bindingi163 – 171NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciPPUT390235:G1GBA-2044-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:PputW619_1983
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877091 – 310Acetaldehyde dehydrogenase 1Add BLAST310

Proteomic databases

PRIDEiB1J6Y6

Interactioni

Protein-protein interaction databases

STRINGi390235.PputW619_1983

Structurei

3D structure databases

ProteinModelPortaliB1J6Y6
SMRiB1J6Y6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OMAiTSAYVHK
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

B1J6Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQKRKVAII GSGNIGTDLM IKILRNAKHL EMAAMVGIDQ ASDGLARAAR
60 70 80 90 100
MGVATTADGV DGLTRLPVFQ DIDFVFDATS AGAHVKNDAF LRQHKASLRM
110 120 130 140 150
IDLTPAAIGP YCVPVVNLEQ HLQAINVNMV TCGGQATIPM VAAVSRVAKV
160 170 180 190 200
HYAEIVASIA SKSAGPGTRA NIDEFTETTS KAIEVIGGAT KGKAIIIMNP
210 220 230 240 250
AEPPLMMRDT VYVLSETADQ KQIAASIEEM AASVQAYVPG YRLKQQVQFE
260 270 280 290 300
QVHNLTLPGQ GTFTGLKTSV FLEVEGAAHY LPAYAGNLDI MTSAALATAE
310
RMAQAMGPLA
Length:310
Mass (Da):32,780
Last modified:April 29, 2008 - v1
Checksum:iB1E76AB1B8753DA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA Translation: ACA72484.1
RefSeqiWP_012313874.1, NC_010501.1

Genome annotation databases

EnsemblBacteriaiACA72484; ACA72484; PputW619_1983
KEGGippw:PputW619_1983

Similar proteinsi

Entry informationi

Entry nameiACDH1_PSEPW
AccessioniPrimary (citable) accession number: B1J6Y6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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