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B1J6Y2

- ACDH2_PSEPW

UniProt

B1J6Y2 - ACDH2_PSEPW

Protein

Acetaldehyde dehydrogenase 2

Gene

PputW619_2008

Organism
Pseudomonas putida (strain W619)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Acyl-thioester intermediateUniRule annotation
    Binding sitei290 – 2901NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 164NADUniRule annotation
    Nucleotide bindingi162 – 1709NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPPUT390235:GHHJ-2054-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Ordered Locus Names:PputW619_2008
    OrganismiPseudomonas putida (strain W619)
    Taxonomic identifieri390235 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000000720: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Acetaldehyde dehydrogenase 2PRO_0000387710Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi390235.PputW619_2008.

    Structurei

    3D structure databases

    ProteinModelPortaliB1J6Y2.
    SMRiB1J6Y2. Positions 5-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHARHEQL.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1J6Y2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSTRIPVAI IGSGNIGTDL MIKILRCSDT LEVGAMVGID PASDGLARAE    50
    RLGVPTTAGG IDGLLALPNF KEIRIAFDAT SAGAHKVHDS KLRAHGVRII 100
    DLTPAAVGPY VVPVVNFAEH AHEPNLNMVT CGGQATIPIV HAVAGVAPVH 150
    YAEIVAAISS KSAGPGTRAN IDEFTETTSR AIVEVGGAAR GKAIIVLNPA 200
    EPPLIMRDTV YCFVPLDADT QAIVDAVEQR VAEVNRYVPG YRLKQHVQFE 250
    HFTENNRQNI PGLGWSTGIK VAVYLEVEGA GHYLPAYAGN LDIMTSAALT 300
    VAERIAQAQF TDQGL 315
    Length:315
    Mass (Da):33,227
    Last modified:April 29, 2008 - v1
    Checksum:iDA8DC3E8B68FCBD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000949 Genomic DNA. Translation: ACA72508.1.
    RefSeqiYP_001748877.1. NC_010501.1.

    Genome annotation databases

    EnsemblBacteriaiACA72508; ACA72508; PputW619_2008.
    GeneIDi6110961.
    KEGGippw:PputW619_2008.
    PATRICi19953858. VBIPsePut93764_2026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000949 Genomic DNA. Translation: ACA72508.1 .
    RefSeqi YP_001748877.1. NC_010501.1.

    3D structure databases

    ProteinModelPortali B1J6Y2.
    SMRi B1J6Y2. Positions 5-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 390235.PputW619_2008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACA72508 ; ACA72508 ; PputW619_2008 .
    GeneIDi 6110961.
    KEGGi ppw:PputW619_2008.
    PATRICi 19953858. VBIPsePut93764_2026.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HARHEQL.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci PPUT390235:GHHJ-2054-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: W619.

    Entry informationi

    Entry nameiACDH2_PSEPW
    AccessioniPrimary (citable) accession number: B1J6Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3