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Protein

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Gene

PputW619_1602

Organism
Pseudomonas putida (strain W619)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).By similarity

Catalytic activityi

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate.
Oxaloacetate = pyruvate + CO2.

Cofactori

a divalent metal cationBy similarityNote: Divalent metal cation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98SubstrateBy similarity1
Metal bindingi99Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding

Enzyme and pathway databases

BioCyciPPUT390235:G1GBA-1656-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC:4.1.3.17)
Short name:
HMG aldolase
Alternative name(s):
Oxaloacetate decarboxylase (EC:4.1.1.3)
Short name:
OAA decarboxylase
Regulator of ribonuclease activity homolog
RraA-like protein
Gene namesi
Ordered Locus Names:PputW619_1602
OrganismiPseudomonas putida (strain W619)
Taxonomic identifieri390235 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000720 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001948671 – 163Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolaseAdd BLAST163

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi390235.PputW619_1602

Structurei

3D structure databases

ProteinModelPortaliB1J596
SMRiB1J596
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 79Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the class II aldolase/RraA-like family.Curated

Phylogenomic databases

eggNOGiENOG4108YYX Bacteria
COG0684 LUCA
HOGENOMiHOG000252803
KOiK02553
OMAiYADWNGV
OrthoDBiPOG091H03SM

Family and domain databases

CDDicd16841 RraA_family, 1 hit
InterProiView protein in InterPro
IPR010203 RraA
IPR005493 RraA/RraA-like
IPR036704 RraA/RraA-like_sf
PfamiView protein in Pfam
PF03737 RraA-like, 1 hit
SUPFAMiSSF89562 SSF89562, 1 hit
TIGRFAMsiTIGR01935 NOT-MenG, 1 hit

Sequencei

Sequence statusi: Complete.

B1J596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHYVTPDLC DAYPDLVQVL EPMFSNFGGR DSFGGQIVTI KCFEDNSRVK
60 70 80 90 100
EQVELDGKGK VLVVDGGGSL RCALLGDMLA EKAAKNGWEG LVIYGCVRDV
110 120 130 140 150
DVLIQTSVGV QALASHPMKT DKRGIGDLNV AVTFAGVTFR PGEYVYADNN
160
GVIVSPSPLE MPQ
Length:163
Mass (Da):17,539
Last modified:April 29, 2008 - v1
Checksum:iA1483A4103088F8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000949 Genomic DNA Translation: ACA72107.1
RefSeqiWP_012313510.1, NC_010501.1

Genome annotation databases

EnsemblBacteriaiACA72107; ACA72107; PputW619_1602
KEGGippw:PputW619_1602

Similar proteinsi

Entry informationi

Entry nameiRRAAH_PSEPW
AccessioniPrimary (citable) accession number: B1J596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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